PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19839650-1	2009	SH2 domain-containing inositol 5-phosphatases 1 (SHIP1) and 2 (SHIP2) are structurally similar proteins that catalyze the degradation of lipid secondary messenger phosphatidylinositol 3,4,5-triphosphate to produce phosphatidylinositol 3,4-diphosphate.	phosphatidylinositol 3,4-diphosphate	214-250	inositol polyphosphate-5-phosphatase D	Homo sapiens	49-54	
23650141-0	2013	How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity?	phosphatidylinositol 3,4-diphosphate	25-38	inositol polyphosphate-5-phosphatase D	Homo sapiens	9-14	
23650141-3	2013	PtdIns(3,4)P2 is commonly reported as a product of the SH2 domain-containing inositol 5-phosphatases 1/2 (SHIP1 and SHIP2) that dephosphorylate PtdIns(3,4,5)P3 at the 5-position.	phosphatidylinositol 3,4-diphosphate	0-13	inositol polyphosphate-5-phosphatase D	Homo sapiens	106-111	
11418650-5	2001	Surprisingly, FcgammaRIIB-dependent degradation of phosphatidylinositol 3,4,5-trisphosphate and conversion into phosphatidylinositol 3,4-bisphosphate occur in SHIP-deficient B cell blasts, demonstrating the function of an additional inositol 5-phosphatase.	phosphatidylinositol 3,4-diphosphate	112-149	inositol polyphosphate-5-phosphatase D	Homo sapiens	159-163	
19909369-9	2009	Current work is further defining the molecular interactions driven by these molecules and identifying the functions of TAPP adapters, which also appear to be involved in lymphocyte adhesion and are specific effectors downstream of the SHIP product phosphatidylinositol-3,4-bisphosphate.	phosphatidylinositol 3,4-diphosphate	248-285	inositol polyphosphate-5-phosphatase D	Homo sapiens	235-239	
14688341-8	2004	Analysis of 3-phosphoinositide generation under activating and inhibitory signaling conditions indicated that recruitment of Bam32 and TAPP2 is inversely correlated with the SHIP substrate/product ratio (phosphatidylinositol 3,4,5-trisphosphate/phosphatidylinositol 3,4-bisphosphate).	phosphatidylinositol 3,4-diphosphate	245-282	inositol polyphosphate-5-phosphatase D	Homo sapiens	174-178	
19622295-1	2009	BACKGROUND AND OBJECTIVE: The hemopoietic-restricted Src homology 2-containing inositol 5"-phosphatase (SHIP) acts as a negative regulator for the proliferation and survival of hematopoietic cells by hydrolysing the phosphoinositide 3-kinase (PI3K)-generated second messenger, PtdIns(3,4,5)-P3 (PI-3,4,5-P3) to PtdIns(3,4)-P2 (PI-3,4-P2).	phosphatidylinositol 3,4-diphosphate	311-325	inositol polyphosphate-5-phosphatase D	Homo sapiens	53-102	
19622295-1	2009	BACKGROUND AND OBJECTIVE: The hemopoietic-restricted Src homology 2-containing inositol 5"-phosphatase (SHIP) acts as a negative regulator for the proliferation and survival of hematopoietic cells by hydrolysing the phosphoinositide 3-kinase (PI3K)-generated second messenger, PtdIns(3,4,5)-P3 (PI-3,4,5-P3) to PtdIns(3,4)-P2 (PI-3,4-P2).	phosphatidylinositol 3,4-diphosphate	311-325	inositol polyphosphate-5-phosphatase D	Homo sapiens	104-108	
10582334-4	1999	Moreover, SHIP has been shown in vivo to be the primary enzyme responsible for breaking down phosphatidylinositol-3,4,5-trisphosphate to phosphatidylinositol-3,4-bisphosphate in normal mast cells and, as a result, limits normal and prevents inappropriate mast cell degranulation.	phosphatidylinositol 3,4-diphosphate	137-174	inositol polyphosphate-5-phosphatase D	Homo sapiens	10-14	
34214875-3	2021	In this study, we compared the phosphoinositide effector proteins AKT1, TAPP1, TAPP2, VAV1 and P-REX1 and the phosphoinositide phosphatases PTEN, SHIP1 and INPP4B for their binding affinities to PtdIns(3,4,5)P3 and/or PtdIns(3,4)P2 using Surface Plasmon Resonance.	phosphatidylinositol 3,4-diphosphate	218-231	inositol polyphosphate-5-phosphatase D	Homo sapiens	146-151	
34214875-7	2021	The SHIP1 mutant E452K detected in carcinoma patients had a 100-fold increased affinity to PtdIns(3,4)P2 but not to PtdIns(3,4,5)P3 compared to SHIP1 WT.	phosphatidylinositol 3,4-diphosphate	91-104	inositol polyphosphate-5-phosphatase D	Homo sapiens	4-9	
25517094-4	2015	This pathway is prominent at the leading edges of cells where phosphatidylinositol-3,4-bisphosphate-produced by the dephosphorylation of phosphatidylinositol-3,4,5-triphosphate by SHIP1 and SHIP2-recruits lamellipodin, which in turn engages endophilin.	phosphatidylinositol 3,4-diphosphate	62-99	inositol polyphosphate-5-phosphatase D	Homo sapiens	180-185	
10066815-3	1999	In vitro, SHIP catalyzes the conversion of the phosphoinositide 3-kinase (PI3K) product phosphatidylinositol 3,4, 5-trisphosphate (PIP3) into phosphatidylinositol 3,4-bisphosphate.	phosphatidylinositol 3,4-diphosphate	142-179	inositol polyphosphate-5-phosphatase D	Homo sapiens	10-14	
9341117-8	1997	Finally, the striking correlation observed between phosphatidylinositol 3,4-bisphosphate production and the tyrosine phosphorylation of SHIP, as well as its relocation to the cytoskeleton upon thrombin stimulation, suggest a role for SHIP in the aggregation-dependent and GpIIb-IIIa-mediated accumulation of this important phosphoinositide.	phosphatidylinositol 3,4-diphosphate	51-88	inositol polyphosphate-5-phosphatase D	Homo sapiens	136-140	
9341117-8	1997	Finally, the striking correlation observed between phosphatidylinositol 3,4-bisphosphate production and the tyrosine phosphorylation of SHIP, as well as its relocation to the cytoskeleton upon thrombin stimulation, suggest a role for SHIP in the aggregation-dependent and GpIIb-IIIa-mediated accumulation of this important phosphoinositide.	phosphatidylinositol 3,4-diphosphate	51-88	inositol polyphosphate-5-phosphatase D	Homo sapiens	234-238	
25723258-2	2015	By converting PI(3,4,5)P3 to PtdIns(3,4)P2 at the plasma membrane, SHIP1 modifies PI3-kinase mediated signaling.	phosphatidylinositol 3,4-diphosphate	29-42	inositol polyphosphate-5-phosphatase D	Homo sapiens	67-72