PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34214875-3 2021 In this study, we compared the phosphoinositide effector proteins AKT1, TAPP1, TAPP2, VAV1 and P-REX1 and the phosphoinositide phosphatases PTEN, SHIP1 and INPP4B for their binding affinities to PtdIns(3,4,5)P3 and/or PtdIns(3,4)P2 using Surface Plasmon Resonance. phosphatidylinositol 3,4-diphosphate 218-231 inositol polyphosphate-5-phosphatase D Homo sapiens 146-151 34214875-7 2021 The SHIP1 mutant E452K detected in carcinoma patients had a 100-fold increased affinity to PtdIns(3,4)P2 but not to PtdIns(3,4,5)P3 compared to SHIP1 WT. phosphatidylinositol 3,4-diphosphate 91-104 inositol polyphosphate-5-phosphatase D Homo sapiens 4-9 25517094-4 2015 This pathway is prominent at the leading edges of cells where phosphatidylinositol-3,4-bisphosphate-produced by the dephosphorylation of phosphatidylinositol-3,4,5-triphosphate by SHIP1 and SHIP2-recruits lamellipodin, which in turn engages endophilin. phosphatidylinositol 3,4-diphosphate 62-99 inositol polyphosphate-5-phosphatase D Homo sapiens 180-185 25723258-2 2015 By converting PI(3,4,5)P3 to PtdIns(3,4)P2 at the plasma membrane, SHIP1 modifies PI3-kinase mediated signaling. phosphatidylinositol 3,4-diphosphate 29-42 inositol polyphosphate-5-phosphatase D Homo sapiens 67-72 19839650-1 2009 SH2 domain-containing inositol 5-phosphatases 1 (SHIP1) and 2 (SHIP2) are structurally similar proteins that catalyze the degradation of lipid secondary messenger phosphatidylinositol 3,4,5-triphosphate to produce phosphatidylinositol 3,4-diphosphate. phosphatidylinositol 3,4-diphosphate 214-250 inositol polyphosphate-5-phosphatase D Homo sapiens 49-54 23650141-0 2013 How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? phosphatidylinositol 3,4-diphosphate 25-38 inositol polyphosphate-5-phosphatase D Homo sapiens 9-14 23650141-3 2013 PtdIns(3,4)P2 is commonly reported as a product of the SH2 domain-containing inositol 5-phosphatases 1/2 (SHIP1 and SHIP2) that dephosphorylate PtdIns(3,4,5)P3 at the 5-position. phosphatidylinositol 3,4-diphosphate 0-13 inositol polyphosphate-5-phosphatase D Homo sapiens 106-111 19909369-9 2009 Current work is further defining the molecular interactions driven by these molecules and identifying the functions of TAPP adapters, which also appear to be involved in lymphocyte adhesion and are specific effectors downstream of the SHIP product phosphatidylinositol-3,4-bisphosphate. phosphatidylinositol 3,4-diphosphate 248-285 inositol polyphosphate-5-phosphatase D Homo sapiens 235-239 14688341-8 2004 Analysis of 3-phosphoinositide generation under activating and inhibitory signaling conditions indicated that recruitment of Bam32 and TAPP2 is inversely correlated with the SHIP substrate/product ratio (phosphatidylinositol 3,4,5-trisphosphate/phosphatidylinositol 3,4-bisphosphate). phosphatidylinositol 3,4-diphosphate 245-282 inositol polyphosphate-5-phosphatase D Homo sapiens 174-178 19622295-1 2009 BACKGROUND AND OBJECTIVE: The hemopoietic-restricted Src homology 2-containing inositol 5"-phosphatase (SHIP) acts as a negative regulator for the proliferation and survival of hematopoietic cells by hydrolysing the phosphoinositide 3-kinase (PI3K)-generated second messenger, PtdIns(3,4,5)-P3 (PI-3,4,5-P3) to PtdIns(3,4)-P2 (PI-3,4-P2). phosphatidylinositol 3,4-diphosphate 311-325 inositol polyphosphate-5-phosphatase D Homo sapiens 53-102 19622295-1 2009 BACKGROUND AND OBJECTIVE: The hemopoietic-restricted Src homology 2-containing inositol 5"-phosphatase (SHIP) acts as a negative regulator for the proliferation and survival of hematopoietic cells by hydrolysing the phosphoinositide 3-kinase (PI3K)-generated second messenger, PtdIns(3,4,5)-P3 (PI-3,4,5-P3) to PtdIns(3,4)-P2 (PI-3,4-P2). phosphatidylinositol 3,4-diphosphate 311-325 inositol polyphosphate-5-phosphatase D Homo sapiens 104-108 11418650-5 2001 Surprisingly, FcgammaRIIB-dependent degradation of phosphatidylinositol 3,4,5-trisphosphate and conversion into phosphatidylinositol 3,4-bisphosphate occur in SHIP-deficient B cell blasts, demonstrating the function of an additional inositol 5-phosphatase. phosphatidylinositol 3,4-diphosphate 112-149 inositol polyphosphate-5-phosphatase D Homo sapiens 159-163 10582334-4 1999 Moreover, SHIP has been shown in vivo to be the primary enzyme responsible for breaking down phosphatidylinositol-3,4,5-trisphosphate to phosphatidylinositol-3,4-bisphosphate in normal mast cells and, as a result, limits normal and prevents inappropriate mast cell degranulation. phosphatidylinositol 3,4-diphosphate 137-174 inositol polyphosphate-5-phosphatase D Homo sapiens 10-14 10066815-3 1999 In vitro, SHIP catalyzes the conversion of the phosphoinositide 3-kinase (PI3K) product phosphatidylinositol 3,4, 5-trisphosphate (PIP3) into phosphatidylinositol 3,4-bisphosphate. phosphatidylinositol 3,4-diphosphate 142-179 inositol polyphosphate-5-phosphatase D Homo sapiens 10-14 9341117-8 1997 Finally, the striking correlation observed between phosphatidylinositol 3,4-bisphosphate production and the tyrosine phosphorylation of SHIP, as well as its relocation to the cytoskeleton upon thrombin stimulation, suggest a role for SHIP in the aggregation-dependent and GpIIb-IIIa-mediated accumulation of this important phosphoinositide. phosphatidylinositol 3,4-diphosphate 51-88 inositol polyphosphate-5-phosphatase D Homo sapiens 136-140 9341117-8 1997 Finally, the striking correlation observed between phosphatidylinositol 3,4-bisphosphate production and the tyrosine phosphorylation of SHIP, as well as its relocation to the cytoskeleton upon thrombin stimulation, suggest a role for SHIP in the aggregation-dependent and GpIIb-IIIa-mediated accumulation of this important phosphoinositide. phosphatidylinositol 3,4-diphosphate 51-88 inositol polyphosphate-5-phosphatase D Homo sapiens 234-238