PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24343720-1	2013	The present study was to determine whether candesartan, an angiotensin II type 1 receptor blocker (ARB), exerts anti-inflammatory effects through inhibiting the toll-like receptor 4 (TLR4) pathway in human renal tubular epithelial cells (HKCs).	candesartan	43-54	toll like receptor 4	Homo sapiens	161-181	
24343720-0	2013	Candesartan inhibits LPS-induced expression increase of toll-like receptor 4 and downstream inflammatory factors likely via angiotensin II type 1 receptor independent pathway in human renal tubular epithelial cells.	candesartan	0-11	toll like receptor 4	Homo sapiens	56-76	
24343720-1	2013	The present study was to determine whether candesartan, an angiotensin II type 1 receptor blocker (ARB), exerts anti-inflammatory effects through inhibiting the toll-like receptor 4 (TLR4) pathway in human renal tubular epithelial cells (HKCs).	candesartan	43-54	toll like receptor 4	Homo sapiens	183-187	
24343720-6	2013	Candesartan reversed LPS-induced upregulation of TLR4 expression, inhibited NF-kappaB activation, and reduced MCP-1 and RANTES release.	candesartan	0-11	toll like receptor 4	Homo sapiens	49-53	
19161983-0	2009	Candesartan attenuates Angiotensin II-induced mesangial cell apoptosis via TLR4/MyD88 pathway.	candesartan	0-11	toll like receptor 4	Homo sapiens	75-79	
19161983-3	2009	We also show that candesartan attenuated the Ang II-induced MC apoptosis, and that this protective effect was dependent on decreased TLR4/MyD88 expression as well as reduced intracellular ROS formation.	candesartan	18-29	toll like receptor 4	Homo sapiens	133-137	
18495130-7	2009	Pretreatment of human monocytes with candesartan significantly decreased Pam3CSK4 or LPS induced TLR2 and TLR4 expression of both mRNA and protein levels (P<0.05 vs. control) along with decrease in the activity of NF-kappaB and the expression of IL-1beta, IL-6, TNF-alpha, and MCP-1.	candesartan	37-48	toll like receptor 4	Homo sapiens	106-110	
18495130-9	2009	CONCLUSION: Pam3CSK4 and LPS induced TLR2 and TLR4 expression at mRNA and protein levels are inhibited by candesartan both in vitro and in vivo.	candesartan	106-117	toll like receptor 4	Homo sapiens	46-50	
18044001-10	2007	Candesartan, an antagonist of the angiotensin II type 1 receptor (AT1), and N-acetylcystine inhibited angiotensin II-induced TLR4 mRNA expression in these cells.	candesartan	0-11	toll like receptor 4	Homo sapiens	125-129