PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17903697-9 2007 Candesartan increased ACE2 mRNA levels in the heart. candesartan 0-11 angiotensin I converting enzyme 2 Rattus norvegicus 22-26 33479758-3 2021 In the lung of healthy rats, we observed that candesartan (an angiotensin type-1, AT1, receptor blocker; ARB) and captopril (an ACE inhibitor; ACEI) up-regulated expression of tissue ACE2 and RAS anti-inflammatory axis receptors (AT2 and Mas receptors). candesartan 46-57 angiotensin I converting enzyme 2 Rattus norvegicus 183-187 33881142-7 2021 (2021), 135, 465-481) showed in rats that captopril and candesartan up-regulated ACE2 expression and the protective RAS pathway in lung tissue. candesartan 56-67 angiotensin I converting enzyme 2 Rattus norvegicus 81-85 34400868-5 2021 Candesartan and CoQ10 as well as their combination suppressed gastrocnemius content of angiotensin II while they raised angiotensin-converting enzyme 2 (ACE2) activity, angiotensin (1-7) expression, and Mas receptor mRNA level. candesartan 0-11 angiotensin I converting enzyme 2 Rattus norvegicus 120-151 34400868-5 2021 Candesartan and CoQ10 as well as their combination suppressed gastrocnemius content of angiotensin II while they raised angiotensin-converting enzyme 2 (ACE2) activity, angiotensin (1-7) expression, and Mas receptor mRNA level. candesartan 0-11 angiotensin I converting enzyme 2 Rattus norvegicus 153-157 22120037-7 2012 Candesartan improved the functional markers in a dose-dependent manner and also upregulated Ang (1-7), ACE2 and mas1 in the myocardium of DCM rats. candesartan 0-11 angiotensin I converting enzyme 2 Rattus norvegicus 103-107