PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31732254-4 2020 An antihypertensive agent, candesartan cilexetic (CDC), was identified as a novel neddylation inhibitor that ATP-competitively suppressing Nedd8-activating enzyme (NAE, E1) in mechanism, which inhibited the cullins neddylation superior than two representative non-covalent NAE inhibitors, M22 and mitoxantrone. candesartan 27-38 NEDD8 ubiquitin like modifier Homo sapiens 139-144