PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12714868-7 2003 The ERK1/2 kinase cascade inhibitor PD 98059 significantly impaired the expression of nNOS in arteries exposed to 200 mmHg for 9 h. However, the angiotensin AT(1) antagonist candesartan and the angiotensin converting enzyme inhibitor perindoprilat did not have any effect under the same experimental conditions. candesartan 174-185 nitric oxide synthase 1 Rattus norvegicus 86-90 11509490-15 2001 The pretreatment by the AT(1) receptor antagonist candesartan (750 ng IR) in SAL-infused rats (n=7) effectively prevented the decrease in RPF (-3+/-3%) elicited by nNOS inhibition and resulted in an increase in GFR (+25+/-12, P<0.05) and a concomitant greater increase in sodium excretion (84+/-12%, P<0.05) compared with control values. candesartan 50-61 nitric oxide synthase 1 Rattus norvegicus 164-168