PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17318787-10	2006	Candesartan-treated rats showed lower levels of vascular CTGF expression, aortic media area, media-to-lumen ratio and collagen density than TT-treated animals.	candesartan	0-11	cellular communication network factor 2	Rattus norvegicus	57-61	
21802905-7	2011	The treatment with candesartan significantly reduced CTGF expression and effectively suppressed the development of fibrotic deposition in diabetic animals.	candesartan	19-30	cellular communication network factor 2	Rattus norvegicus	53-57	
16408293-11	2006	After 72 h, the expression of CTGF and collagen type IV proteins in high-glucose cultures increased significantly and this increase was effectively attenuated by the candesartan or the ramiprilat.	candesartan	166-177	cellular communication network factor 2	Rattus norvegicus	30-34	
17096069-6	2006	RESULTS: As a preventive effect, candesartan reduced the hepatic Hyp content by 36%, alpha-SMA-positive cells by 65%, hepatic TGF-beta1 content by 35%, and the expression of collagen I by 72%, TGF-beta1 by 67%, and CTGF mRNA by 69%.	candesartan	33-44	cellular communication network factor 2	Rattus norvegicus	215-219	
17096069-7	2006	As a therapeutic effect, candesartan reduced the hepatic Hyp content by 48%, TGF-beta1 content by 54%, and the expression of collagen I by 47%, TGF-beta1 by 43%, and CTGF mRNA by 53%.	candesartan	25-36	cellular communication network factor 2	Rattus norvegicus	166-170	
16685210-7	2006	In DS/H rats, treatment with candesartan did not alter blood pressure, but resulted in a marked improvement of the hemodynamic deterioration; these therapeutic effects were accompanied by decreases in myocardial NADPH oxidase activity, TBARS contents and the expression of TGF-beta, CTGF, p22phox, gp91phox and UCP-2.	candesartan	29-40	cellular communication network factor 2	Rattus norvegicus	283-287	
15699040-4	2005	Infusion of AngII in rats increased CTGF mRNA expression by 15-fold, which was completely inhibited by co-infusion with AT1 receptor antagonist, candesartan.	candesartan	145-156	cellular communication network factor 2	Rattus norvegicus	36-40