PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29845261-13 2018 In addition, Candesartan treatment enhanced NF-kappaB activity, as well as TGF-beta and vascular endothelial growth factor expression which led to improved levels of sFlt-1, insulin resistance homeostasis and associated cardiovascular risk factors. candesartan 13-24 transforming growth factor, beta 1 Mus musculus 75-83 22892395-6 2012 Candesartan treatment reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGFbeta1 while increasing expression of TGFbeta3. candesartan 0-11 transforming growth factor, beta 1 Mus musculus 257-265 32822012-6 2021 Moreover, the ECM depletion (including collagen I and hyaluronan) by candesartan was achieved through the downregulation of TGF-beta1 in vitro, consistent with in vivo results. candesartan 69-80 transforming growth factor, beta 1 Mus musculus 124-133 22326534-4 2012 Further data showed that Candesartan inhibited TGF-beta1 signal-induced epithelial-to-mesenchymal transition (EMT) through attenuating matrix metalloproteinases (MMP-9), such effect was abolished by knocking-down Smad7. candesartan 25-36 transforming growth factor, beta 1 Mus musculus 47-56 20628203-6 2010 TGF-beta upregulation in astrocytes and microglia during EAE was blocked with candesartan (CA), an inhibitor of AT1R. candesartan 78-89 transforming growth factor, beta 1 Mus musculus 0-8 28670881-7 2017 Results: Candesartan and/or CoQ10 inducedsignificant improvement of renal and mitochondrial functions with significant increase in tissue CAT, GR, Nrf2 andHO-1 content associated with significant decrease in the kidney weight/body weight ratio, tissue TGF-beta1, TNF-alpha andIL-6 and alleviation of the histopathological and immunohistochemical changes as compared to carboplatin alonegroup. candesartan 9-20 transforming growth factor, beta 1 Mus musculus 252-261