PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22576470-7	2012	Treatment of cultured THP-1 macrophages in vitro with candesartan resulted in a similar decrease in ACAT1 expression.	candesartan	54-65	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	100-105	
22576470-8	2012	In the kidney, glomerular lipid accumulation, mesangial expansion, and albuminuria were significantly regressed after treatment with high-dose candesartan, while biglycan and ACAT1 expressions were decreased.	candesartan	143-154	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	175-180	
22576470-9	2012	CONCLUSION: These results suggest that regression of established atherosclerosis lesions in ApoE-deficient mice is feasible using high-dose candesartan, by mechanisms involving (i) a decrease in the lipid-retaining proteoglycan biglycan, and (ii) suppression of ACAT1 expression resulting in increased free cholesterol for lipid release.	candesartan	140-151	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	262-267