PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16790507-9	2006	Furthermore, fasudil prevented MYPT1 phosphorylation and markedly decreased alpha-smooth muscle actin staining, numbers of monocytes/macrophages, mRNA levels of types I and III collagen, TGF-beta, connective tissue growth factor and monocyte chemoattractant protein-1, and Smad2/3 activity in renal cortical tissues.	fasudil	13-20	transforming growth factor, beta 1	Rattus norvegicus	187-195	
21330937-8	2011	Aortic mRNA and protein levels of transforming growth factor-beta1 (TGF-beta1), plasminogen activator inhibitor 1 (PAI-1), and monocyte chemoattractant protein 1 (MCP-1) were significantly (P<0.05) higher in the untreated DOCA rats and were normalized by fasudil administration.	fasudil	258-265	transforming growth factor, beta 1	Rattus norvegicus	34-66	
28493050-5	2017	Fasudil could reduce the elevated tumor necrosis factor (TNF)-alpha (70.2 +- 14.1 vs. 25.3 +- 5.2) and transforming growth factor (TGF-beta) levels and restored the deficit in antioxidant level of the diabetic aorta.	fasudil	0-7	transforming growth factor, beta 1	Rattus norvegicus	131-139	
31219429-4	2019	Fasudil treatment reduced the expression of TGFbeta1, RhoGDI1, and RhoGDI2 in addition to vascular remodeling in the rat balloon injury model.	fasudil	0-7	transforming growth factor, beta 1	Rattus norvegicus	44-52	
30229844-9	2018	Treatment with fasudil or captopril suppressed not only the inflammation reaction but also the accumulation of the extracellular matrix due to the downregulation of TGF-beta1 and MMP-9/TIMP-1, which induces the amelioration of the liver fibrosis with diabetes.	fasudil	15-22	transforming growth factor, beta 1	Rattus norvegicus	165-174	
34623176-8	2021	In the heart, increased levels of the pro-fibrotic proteins Col-I, Col-III and TGF-beta1 and gene expression of pro-remodeling molecules TGF-beta1, CTGF, MCP-1 and PAI-1 and the pro-oxidative molecules gp91phox and p22phox were significantly reduced by HCTZ, fasudil and spironolactone.	fasudil	259-266	transforming growth factor, beta 1	Rattus norvegicus	79-88	
34623176-8	2021	In the heart, increased levels of the pro-fibrotic proteins Col-I, Col-III and TGF-beta1 and gene expression of pro-remodeling molecules TGF-beta1, CTGF, MCP-1 and PAI-1 and the pro-oxidative molecules gp91phox and p22phox were significantly reduced by HCTZ, fasudil and spironolactone.	fasudil	259-266	transforming growth factor, beta 1	Rattus norvegicus	137-146	
23376009-5	2013	In STZ-induced diabetic rats, treatment with ROCK inhibitor fasudil suppressed the RhoA/ROCK activation and NF-kappaB nuclear translocation, and significantly reduced the renal FN, ICAM-1 and TGF-beta1 protein levels.	fasudil	60-67	transforming growth factor, beta 1	Rattus norvegicus	192-201	
23859538-8	2013	Compared with PD group, the mRNA and protein expressions of TGF-beta1, alphaSMA and Collagen I were significantly downregulated in fasudil treatment groups in a dose-dependent manner, and the expression of VEGF and peritoneal MVD was also significantly downregulated in fasudil treatment groups in a dose-dependent manner.	fasudil	131-138	transforming growth factor, beta 1	Rattus norvegicus	60-69