PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33969676-7 2021 The results showed that the administration of Fasudil improved learning and memory ability, elevated the concentration of antioxidative substances and decreased lipid peroxides, as well as inhibited neuronal apoptosis by increasing the expression of B-cell lymphoma-2 (Bcl-2) (p < 0.05), reducing Bcl-2 Associated X (Bax) (p < 0.05) and cleaved caspase-3 (p < 0.05) of APP/PS1 mice. fasudil 46-53 caspase 3 Mus musculus 345-354 33357780-13 2021 RESULTS: In vivo, fasudil treatment ameliorated DOX-induced immunofluorescence reaction of DNA damage-related factors (8-OHdG), decreased the expression of Bax, Caspase-3, p16, p21 and p53, and increased the expression of protein of Bcl-2, Bmi-1 and Sirt-1. fasudil 18-25 caspase 3 Mus musculus 161-170 31482248-6 2019 In addition, fasudil reversed Abeta1-42-induced decreased expression of Bcl-2 and increases in caspase-3, cleaved-PARP, phospho-JNK(Thr183/Tyr185), and phospho-ASK1(Ser966). fasudil 13-20 caspase 3 Mus musculus 95-104