PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27101974-4	2016	Fasudil treatment significantly reduced alpha-Syn aggregation in vitro in a H4 cell culture model as well as in a cell-free assay.	fasudil	0-7	synuclein alpha	Homo sapiens	40-49	
27101974-5	2016	Nuclear magnetic resonance spectroscopy analysis revealed a direct binding of Fasudil to tyrosine residues Y133 and Y136 in the C-terminal region of alpha-Syn.	fasudil	78-85	synuclein alpha	Homo sapiens	149-158	
26683082-0	2016	Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T alpha-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway.	fasudil	0-7	synuclein alpha	Homo sapiens	77-92	
26565388-6	2016	Furthermore, Fasudil resulted in a significant attenuation of dopamine cell loss, alpha-synuclein accumulation and inflammatory response with the reversion of inflammatory M1 to anti-inflammatory M2 microglia, decreased NF-kB activation, and IL-12 and TNF-alpha generation in the SN and olfactory bulb in this model.	fasudil	13-20	synuclein alpha	Homo sapiens	82-97	
26683082-3	2016	However, it is not known if fasudil, the only ROCK inhibitor available in clinical setting, could promote the degradation of alpha-syn, and ameliorate the alpha-syn induced neurotoxicity.	fasudil	28-35	synuclein alpha	Homo sapiens	125-134	
26683082-4	2016	In this regard, we investigated the effect of fasudil on neurite injury caused by A53T alpha-syn overexpression and the implicated pathway it might mediate.	fasudil	46-53	synuclein alpha	Homo sapiens	87-96	
26683082-6	2016	Fasudil, the ROCK inhibitor, ameliorated such neurotoxicity and promoted the clearance of A53T alpha-syn.	fasudil	0-7	synuclein alpha	Homo sapiens	95-104	
35130691-3	2022	Here we present long-time-scale, atomic-level molecular dynamics (MD) simulations of monomeric alpha-synuclein (an IDP whose aggregation is associated with Parkinson"s disease) binding the small-molecule drug fasudil in which the observed protein-ligand interactions were found to be in good agreement with previously reported NMR chemical shift data.	fasudil	209-216	synuclein alpha	Homo sapiens	95-110	
35130691-4	2022	In our simulations, fasudil, when bound, favored certain charge-charge and pi-stacking interactions near the C terminus of alpha-synuclein but tended not to form these interactions simultaneously, rather breaking one of these interactions and forming another nearby (a mechanism we term dynamic shuttling).	fasudil	20-27	synuclein alpha	Homo sapiens	123-138