PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29722320-0	2018	The Rho-associated kinase inhibitors Y27632 and fasudil promote microglial migration in the spinal cord via the ERK signaling pathway.	fasudil	48-55	mitogen-activated protein kinase 1	Homo sapiens	112-115	
29722320-10	2018	The ERK inhibitor U0126 suppressed these effects of Y27632 and fasudil.	fasudil	63-70	mitogen-activated protein kinase 1	Homo sapiens	4-7	
29722320-11	2018	These findings suggest that the ROCK inhibitors Y27632 and fasudil promote microglial migration in the spinal cord through the ERK signaling pathway.	fasudil	59-66	mitogen-activated protein kinase 1	Homo sapiens	127-130	
22040563-0	2011	Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip1 via the ERK signal pathway.	fasudil	0-7	mitogen-activated protein kinase 1	Homo sapiens	148-151	
27441000-0	2016	Fasudil inhibits LPS-induced migration of retinal microglial cells via regulating p38-MAPK signaling pathway.	fasudil	0-7	mitogen-activated protein kinase 1	Homo sapiens	82-85	
27441000-7	2016	Moreover, fasudil reduced the level of phosphor-p38 mitogen-activated protein kinase (p-p38-MAPK) in a concentration-dependent manner, without effects on the levels of phospho-p44/42 (p-ERK1/2) and phospho-c-Jun N-terminal kinase (p-JNK).	fasudil	10-17	mitogen-activated protein kinase 1	Homo sapiens	48-51	
27441000-7	2016	Moreover, fasudil reduced the level of phosphor-p38 mitogen-activated protein kinase (p-p38-MAPK) in a concentration-dependent manner, without effects on the levels of phospho-p44/42 (p-ERK1/2) and phospho-c-Jun N-terminal kinase (p-JNK).	fasudil	10-17	mitogen-activated protein kinase 1	Homo sapiens	88-96	
27441000-8	2016	Cotreatment with SB203580 (a p38 inhibitor) and fasudil resulted in the synergistic reduction of MMP-2, MMP-9, and p-p38-MAPK, as well as a reduction in the LPS-stimulated migration capabilities of the RMG cells, suggesting fasudil suppresses the LPS-stimulated migration of RMG cells via directly downregulating the p38-MAPK signaling pathway.	fasudil	48-55	mitogen-activated protein kinase 1	Homo sapiens	117-125	
27441000-8	2016	Cotreatment with SB203580 (a p38 inhibitor) and fasudil resulted in the synergistic reduction of MMP-2, MMP-9, and p-p38-MAPK, as well as a reduction in the LPS-stimulated migration capabilities of the RMG cells, suggesting fasudil suppresses the LPS-stimulated migration of RMG cells via directly downregulating the p38-MAPK signaling pathway.	fasudil	48-55	mitogen-activated protein kinase 1	Homo sapiens	117-120	
27441000-8	2016	Cotreatment with SB203580 (a p38 inhibitor) and fasudil resulted in the synergistic reduction of MMP-2, MMP-9, and p-p38-MAPK, as well as a reduction in the LPS-stimulated migration capabilities of the RMG cells, suggesting fasudil suppresses the LPS-stimulated migration of RMG cells via directly downregulating the p38-MAPK signaling pathway.	fasudil	224-231	mitogen-activated protein kinase 1	Homo sapiens	29-32	
27441000-9	2016	CONCLUSIONS: Our studies indicated that fasudil inhibited LPS-stimulated RMG cell migration via suppression of the p38-MAPK signaling pathway.	fasudil	40-47	mitogen-activated protein kinase 1	Homo sapiens	115-118	
22040563-11	2011	PDGF markedly induced ROCK activity and ERK activity with a peak at 15 minutes, which were significantly inhibited by fasudil.	fasudil	118-125	mitogen-activated protein kinase 1	Homo sapiens	40-43	
22040563-13	2011	CONCLUSION: RhoA/ROCK is vital for PDFG-induced human PASMC proliferation, and fasudil effectively inhibited PDGF-induced human PASMC proliferation by up-regulation of p27(Kip1), which may be associated with inhibition of ERK activity.	fasudil	79-86	mitogen-activated protein kinase 1	Homo sapiens	222-225	
21166955-6	2011	Furthermore, HA1077 attenuated the phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and the DNA binding activity of activator protein-1, a key downstream transcriptional factor of ERK1/2.	fasudil	13-19	mitogen-activated protein kinase 1	Homo sapiens	54-100	
19052484-8	2009	In addition, fasudil significantly decreased 5-HT-induced JNK activation, ERK translocation to the nucleus and subsequent c-fos and c-jun expression.	fasudil	13-20	mitogen-activated protein kinase 1	Homo sapiens	74-77	
19052484-10	2009	Fasudil effectively suppressed 5-HT-induced PASMC proliferation and cell-cycle progression, which was associated with inhibition of JNK activation, ERK translocation to nucleus and subsequent c-fos and c-jun expression.	fasudil	0-7	mitogen-activated protein kinase 1	Homo sapiens	148-151	
15998434-9	2005	Fasudil inhibited phosphorylation of ERK1/2, JNK, and p38.	fasudil	0-7	mitogen-activated protein kinase 1	Homo sapiens	54-57