PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21474569-11 2011 CsA induced expression of p53, the degree of which was attenuated by fasudil in association with decreases of proapoptotic markers such as Bad, Bax, and total/cleaved caspase-3. fasudil 69-76 BCL2 associated X, apoptosis regulator Rattus norvegicus 144-147 23257088-10 2012 CONCLUSION: Fasudil can inhibit the abnormal expression of apoptosis regulatory proteins (Bcl-2 and Bax) induced by omethoate, which might be one of the factors that reduce the toxic effect of omethoate on CMs. fasudil 12-19 BCL2 associated X, apoptosis regulator Rattus norvegicus 100-103 22072613-7 2012 Furthermore, fasudil inhibited apoptosis induced by T(4) as evidenced by the detection of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells and the expressions of bax and bcl-2. fasudil 13-20 BCL2 associated X, apoptosis regulator Rattus norvegicus 189-192 32650141-11 2020 Furthermore, Western blot results showed fasudil-attenuated apoptosis through a raised Bcl-2/Bax rate and enhanced autophagy levels through raised beclin-1, decreased p62, and the elevated rate of LC3 II/LC3 I. fasudil 41-48 BCL2 associated X, apoptosis regulator Rattus norvegicus 93-96 21061151-0 2011 Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway. fasudil 0-7 BCL2 associated X, apoptosis regulator Rattus norvegicus 74-77 27122753-6 2013 After the administration of fasudil, hemodynamic levels improved (p < 0.05), expression levels of Rho kinase mRNA and Bax (p < 0.01) decreased, expression levels of bcl-2 increased, and with the added element of dosage increase, the effect was significant (p < 0.05). fasudil 28-35 BCL2 associated X, apoptosis regulator Rattus norvegicus 121-124 24406296-5 2014 The results suggested that fasudil effectively prevented LPS-induced injury of rat PMVECs, as determined by MTT assay, LDH activity assay, apoptosis and western blot analysis of apoptosis-related proteins Bcl-2 and Bax. fasudil 27-34 BCL2 associated X, apoptosis regulator Rattus norvegicus 215-218 25317813-7 2014 RESULTS: The high-dose fasudil (10 mg/kg) pretreatment group and IPO group significantly improved post-ischemia cardiac function, reduced myocardial infarct size, attenuated cardiomyocyte apoptosis, decreased the release of LDH, increased expression of phospho-Akt, phospho-eNOS and Bcl-2, and reduced expression of Bax compared with the control group (p < 0.05). fasudil 23-30 BCL2 associated X, apoptosis regulator Rattus norvegicus 316-319 25317813-8 2014 In addition, the high-dose fasudil pretreatment combined with IPO group could further improved post-ischemia cardiac function, reduced myocardial infarct size, attenuated cardiomyocyte apoptosis, decreased the release of LDH, increased expression of phospho-Akt, phospho-eNOS and Bcl-2, and reduced expression of Bax compared with the single treatment groups (p < 0.05). fasudil 27-34 BCL2 associated X, apoptosis regulator Rattus norvegicus 313-316 25317813-9 2014 CONCLUSIONS: The combination of high-dose fasudil pretreatment and IPO had a synergistic protective effect on myocardial ischemia/reperfusion injury, which was mediated via upregulating the PI3K/Akt/eNOS pathway, increasing expression of antiapoptotic Bcl-2, and decreasing expression of proapoptotic Bax. fasudil 42-49 BCL2 associated X, apoptosis regulator Rattus norvegicus 301-304 29745021-7 2018 RESULTS: Fasudil, SB203580, and SP600125 effectively inhibited the HG-induced early apoptosis increase and decreased Bax mRNA expression, the Bax/Bcl-2 protein expression ratio, and cleaved caspase-3 protein levels in the cardiomyocytes; this was accompanied by upregulation of the Bcl-2 mRNA. fasudil 9-16 BCL2 associated X, apoptosis regulator Rattus norvegicus 117-120 29745021-7 2018 RESULTS: Fasudil, SB203580, and SP600125 effectively inhibited the HG-induced early apoptosis increase and decreased Bax mRNA expression, the Bax/Bcl-2 protein expression ratio, and cleaved caspase-3 protein levels in the cardiomyocytes; this was accompanied by upregulation of the Bcl-2 mRNA. fasudil 9-16 BCL2 associated X, apoptosis regulator Rattus norvegicus 142-145 27333569-9 2016 Fasudil also reversed the high glucose-suppressed Bcl-2 levels and decreased the high glucose-induced Bax levels. fasudil 0-7 BCL2 associated X, apoptosis regulator Rattus norvegicus 102-105