PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33278350-11	2021	Pharmacological inactivation of ROCK1/2 with Fasudil further blocked the growth and survival of HCC both in vitro and in vivo.	fasudil	45-52	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	32-39	
33633690-3	2020	Y27632 and fasudil are two common ROCK1 inhibitors; however, they have varying non-specific selectivity to inhibit other AGC kinase subfamily members and whole-body pharmacological approaches lack tissue-specific insight.	fasudil	11-18	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	34-39	
28841710-7	2017	Inhibition of ROCK kinase activity by a small molecule inhibitor (fasudil) resulted in moderate (IC50s of 6-71 muM) inhibition of PDAC cell proliferation, migration, and activation of co-cultured stellate cells.	fasudil	66-73	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	14-18	
32829478-7	2020	The designed leads showed better binding than the approved drug fasudil and also interacted with the key hinge region residue Met156 of ROCK I.	fasudil	64-71	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	136-142	
32619776-4	2020	It is suggested that the substitution of Fasudil"s 1,4-diazepane moiety with rigid ring such as Ripasudil and Dimehtylfasudil would render the resulting inhibitors of ROCK-II over ROCK-I (II-o-I) selectivity, while the substitution with long, flexible group such as H-89 and BDBM92607 tends to have I-o-II selectivity.	fasudil	41-48	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	180-194	
30044647-1	2018	In this study, we synthesized a new congener series of N-sulphonylhydrazones designed as candidate ROCK inhibitors using the molecular hybridization of the clinically approved drug fasudil (1) and the IKK-beta inhibitor LASSBio-1524 (2).	fasudil	181-188	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	99-103	
28225457-0	2017	RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro.	fasudil	32-39	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	5-9	
28225457-4	2017	Inhibition of the RhoA/ROCK signaling pathway by the pharmacological inhibitor fasudil reduced vascular-like channels of U2OS cells in Matrigel.	fasudil	79-86	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	23-27	
28225457-7	2017	In this context, we showed that the RhoA/ROCK signaling pathway is a novel regulator in VM of U2OS OS cells and suggest that fasudil in conjunction with established treatments may present a novel therapeutic strategy for OS.	fasudil	125-132	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	41-45	
22041269-6	2011	(2)Under the high glucose situation, after the fasudil pretreatment with different concentrations and 24 h or 48 h culture with high glucose, RhoA, ROCK-I, CTGF mRNA expression was significantly decreased in HG + F, compared with HG, and there was certain concentration-dependence.	fasudil	47-54	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	148-154	
23094262-3	2012	RESULTS: DEX and fasudil significantly inhibited U937 cell adhesion rates under PMA stimulation and inhibited ROCK1 activity.	fasudil	17-24	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	110-115	
22041269-1	2011	OBJECTIVE: To study the effect of fasudil on inhibiting the Rho/ROCK signaling pathway under high glucose in human mesangial cells (HMCs) inflammation and fibrosis.	fasudil	34-41	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	64-68	
28510599-2	2017	While the use of nonselective ROCK inhibitors like fasudil together with rt-PA may be hindered by possible hypotensive side-effects and inadequate capacity to block detrimental rt-PA activity in brain endothelial cells (BECs), selective ROCK-2 inhibition may overcome these limitations.	fasudil	51-58	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	30-34	
26481340-9	2015	However, the addition of anti-ROCK I/II mixed antibodies in MS serum partially declined ROCK activity, but did not improve neurite outgrowth of neurons, revealing that Fasudil should prevent synaptic damage possibly through inhibiting intracellular ROCK activation mediated with MS serum.	fasudil	168-175	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	30-36	
25931586-6	2015	In addition to the phenotype observed after ROCK1 knockdown, treatment with the approved ROCK inhibitor fasudil resulted in increased apoptosis and decreased viability of primary AML cells.	fasudil	104-111	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	44-49	
25400825-9	2014	Simultaneously, the apoptosis aroused by high glucose was also prevented considerably by fasudil, a kind of pharmacological inhibitor of RhoA/ROCK1 pathway.	fasudil	89-96	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	142-147	
21917869-3	2011	DESIGN: To assess the use of fasudil, a selective ROCK inhibitor, for the medical treatment of endometriosis-associated fibrosis, the effects of this agent on the cell proliferation, apoptosis, cell cycle, morphology, cell density, and contractility of ECSC were investigated.	fasudil	29-36	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	50-54	
21917869-7	2011	The expression of alpha-smooth muscle actin, RhoA, ROCK-I, and ROCK-II proteins was inhibited by fasudil administration.	fasudil	97-104	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	51-57	
33779714-12	2021	CONCLUSIONS: Fasudil mitigated IR by the promotion of cell proliferation, inhibition of apoptosis and inflammation and regulation of RhoA/ROCK/insulin/NF-kappaB signalling pathway through in vitro studies.	fasudil	13-20	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	138-142