PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18182482-4	2008	We have shown previously (Kimchi-Sarfaty et al., 2002) that treatment of NCX1-transfected human embryonic kidney (HEK) 293 cells with the immunosuppressive cyclosporin A (CsA) and its nonimmunosuppressive analog PSC833 (valspodar) results in down-regulation of surface expression and transport activity of the protein without a decrease in expression of cell NCX1 protein.	Cyclosporine	156-169	solute carrier family 8 member A1	Homo sapiens	73-77	
20681522-6	2010	We have shown that treatment of transfected HEK 293 cells expressing the Na(+)-Ca(2+) exchanger NCX1 with CsA results in downregulation of surface expression and transport activity, without any reduction in the total level of cell NCX1 protein [Kimchi-Sarfaty, C., et al.	Cyclosporine	106-109	solute carrier family 8 member A1	Homo sapiens	96-100	
20681522-6	2010	We have shown that treatment of transfected HEK 293 cells expressing the Na(+)-Ca(2+) exchanger NCX1 with CsA results in downregulation of surface expression and transport activity, without any reduction in the total level of cell NCX1 protein [Kimchi-Sarfaty, C., et al.	Cyclosporine	106-109	solute carrier family 8 member A1	Homo sapiens	231-235	
20681522-13	2010	Overexpression of CypA or its R55A mutant, which exhibits a substantially reduced PPIase activity, alleviated the reduction of NCX1 surface expression caused by CsA treatment, suggesting that the PPIase domain was probably not mandatory for NCX1 functional expression.	Cyclosporine	161-164	solute carrier family 8 member A1	Homo sapiens	127-131	
18182482-4	2008	We have shown previously (Kimchi-Sarfaty et al., 2002) that treatment of NCX1-transfected human embryonic kidney (HEK) 293 cells with the immunosuppressive cyclosporin A (CsA) and its nonimmunosuppressive analog PSC833 (valspodar) results in down-regulation of surface expression and transport activity of the protein without a decrease in expression of cell NCX1 protein.	Cyclosporine	156-169	solute carrier family 8 member A1	Homo sapiens	359-363	
18182482-4	2008	We have shown previously (Kimchi-Sarfaty et al., 2002) that treatment of NCX1-transfected human embryonic kidney (HEK) 293 cells with the immunosuppressive cyclosporin A (CsA) and its nonimmunosuppressive analog PSC833 (valspodar) results in down-regulation of surface expression and transport activity of the protein without a decrease in expression of cell NCX1 protein.	Cyclosporine	171-174	solute carrier family 8 member A1	Homo sapiens	73-77	
18182482-4	2008	We have shown previously (Kimchi-Sarfaty et al., 2002) that treatment of NCX1-transfected human embryonic kidney (HEK) 293 cells with the immunosuppressive cyclosporin A (CsA) and its nonimmunosuppressive analog PSC833 (valspodar) results in down-regulation of surface expression and transport activity of the protein without a decrease in expression of cell NCX1 protein.	Cyclosporine	171-174	solute carrier family 8 member A1	Homo sapiens	359-363	
23224887-2	2013	We have shown that cyclosporin A (CsA) treatment of NCX1-, NCX2-, or NCX3-transfected HEK 293 cells and non-transfected H9c2, L6, and aortic smooth muscle cells, which express NCX1 protein naturally, reduces NCX surface expression and transport activity but has no impact on total cell NCX protein.	Cyclosporine	34-37	solute carrier family 8 member A1	Homo sapiens	52-56	
11700317-0	2002	Transport activity and surface expression of the Na+-Ca2+ exchanger NCX1 are inhibited by the immunosuppressive agent cyclosporin A and by the nonimmunosuppressive agent PSC833.	Cyclosporine	118-131	solute carrier family 8 member A1	Homo sapiens	68-72	
11700317-1	2002	Cyclosporin A (CsA) treatment of HEK 293 cells expressing the rat heart RHE-1 (NCX1.1, EMBL accession number ) or the rat brain RBE-2 (NCX1.5, GenBank(TM) accession number ) Na(+)-Ca(2+) exchanger inhibited their transport activity in a concentration-dependent manner.	Cyclosporine	0-13	solute carrier family 8 member A1	Homo sapiens	79-83	
12502559-6	2002	Reduced surface expression of the Na(+)/Ca(2+) exchanger NCX1 is also observed when HEK293 cells expressing the transporter are treated with cyclosporin A (CsA) or with PSC833.	Cyclosporine	141-154	solute carrier family 8 member A1	Homo sapiens	57-61	
12502559-6	2002	Reduced surface expression of the Na(+)/Ca(2+) exchanger NCX1 is also observed when HEK293 cells expressing the transporter are treated with cyclosporin A (CsA) or with PSC833.	Cyclosporine	156-159	solute carrier family 8 member A1	Homo sapiens	57-61	
25944722-10	2015	In motor neurons it was also inhibited substantially by CGP37157 and cyclosporine-A, the blockers of Na(+)/Ca(2+) exchanger and mitochondrial permeability transition pore (MPTP) respectively, whereas no effect of these agents was observed in other spinal neurons.	Cyclosporine	69-83	solute carrier family 8 member A1	Homo sapiens	101-123	
23224887-3	2013	Similar effect on functional expression of NCX1 protein can be obtained also without CsA treatment by knockdown of cell cyclophilin A (CypA), one of the cellular receptor of CsA.	Cyclosporine	174-177	solute carrier family 8 member A1	Homo sapiens	43-47	
23224887-4	2013	This suggests that CypA has a role in acquisition of function competence of NCX1 protein.Unlike CsA treatment, which affects the functional expression of all three mammalian NCX proteins similarly, FK506 and rapamycin treatment modulates only the functional expression of NCX2 and NCX3 proteins.	Cyclosporine	96-99	solute carrier family 8 member A1	Homo sapiens	76-80