PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12594849-8 2003 Cyclosporin A strongly inhibited IL-4, but not IL-10 secretion. Cyclosporine 0-13 interleukin 4 Mus musculus 33-37 19145636-5 2009 Moreover, the expression of Th1/Th2 mRNA cytokines (IL-2, IL-4, IL-5, IL-13) from mouse splenocytes was inhibited severely as was cyclosporine A. Cyclosporine 130-144 interleukin 4 Mus musculus 58-62 19627009-6 2009 Simultaneously, the level of IL-2 and IL-4 in leukemia mice treated with FK506 and CSA decreased significantly than those of intact or leukemia control mice. Cyclosporine 83-86 interleukin 4 Mus musculus 38-42 19899977-10 2009 In quantitative PCR, cyclosporin A suppressed the expression of IL-4 and IL-5 mRNA but did not suppress the expression of transforming growth factor (TGF)-beta 1, whereas betamethasone suppressed the expression of IL-4, IL-5, and TGF-beta 1. Cyclosporine 21-34 interleukin 4 Mus musculus 64-68 11275261-7 2000 Both ionomycin and CsA also enhance IL-4-induced transcriptional activity of a STAT6-linked promoter-reporter construct. Cyclosporine 19-22 interleukin 4 Mus musculus 36-40 9973482-7 1999 Wortmannin and cyclosporin A inhibited Fc epsilon RI-mediated production of TNF-alpha and IL-4 in addition to serotonin release in BMMC. Cyclosporine 15-28 interleukin 4 Mus musculus 90-94 10573060-10 1999 Addition of IL-4 from the start of DC cultures conferred resistance to CsA-induced inhibition of NF-kappaB nuclear translocation and DC maturation. Cyclosporine 71-74 interleukin 4 Mus musculus 12-16 10064056-5 1999 Production of both IL-4 by the Th2 clones and IFN-gamma by the Th1 clone were inhibited by the immunosuppressive agent cyclosporin A. Cyclosporine 119-132 interleukin 4 Mus musculus 19-23 9336339-6 1997 Contrary to the above in vivo findings, the immunosuppressors, FK-506 and cyclosporin A, inhibited the production of interferon-gamma and interleukin-2 by cultured Th1 cells (1E10.H2 cells) and of interleukin-4 and -5 by Th2 cells (D10.G4.1 cells) in vitro. Cyclosporine 74-87 interleukin 4 Mus musculus 197-217 9723954-8 1998 Cyclosporin A (10, 100 ng ml(-1)) and dexamethasone (10, 100 ng ml(-1) suppressed the production of IL-5 as well as IL-2 and IL-4 by FJ17 in vitro. Cyclosporine 0-13 interleukin 4 Mus musculus 125-129 8906214-10 1996 Cyclosporin A inhibited in vivo production of IFN-gamma, IL-4, and IL-5 by approximately 80%, but not that of IL-6. Cyclosporine 0-13 interleukin 4 Mus musculus 57-61 8912887-4 1996 We also found that CsA-treatment decreased the expression of lck kinase of T cells and the production of IL-2 in response to concanavalin A (ConA), with minimum effect on IL-4 production. Cyclosporine 19-22 interleukin 4 Mus musculus 171-175 7723593-6 1995 Taken together with the observation that CsA and IPD-1151T suppressed IL-4 and IL-5 production by CA-stimulated D10 cells in vitro, the present results strongly suggest that agents capable of down-regulating Th2 cell cytokine production may attenuate allergic inflammation by impairing the recruitment of eosinophils that is mediated by Th2 cells. Cyclosporine 41-44 interleukin 4 Mus musculus 70-74 7988651-0 1994 The effect of different corticosteroids and cyclosporin A on interleukin-4 and interleukin-5 release from murine TH2-type T cells. Cyclosporine 44-57 interleukin 4 Mus musculus 61-74 7518620-6 1994 CsA very effectively inhibits expression of IL-2, IFN-gamma, and IL-4, but it inhibits IL-10 expression only 65%. Cyclosporine 0-3 interleukin 4 Mus musculus 65-69 7988651-3 1994 In order to examine the effects of corticosteroids and cyclosporin A on anti-CD3-induced production of interleukin-4 and interleukin-5 we used the murine TH2-type cell clone D10.G4.1. Cyclosporine 55-68 interleukin 4 Mus musculus 103-116 7911489-4 1994 However, the induction of the IL-3, IL-4, and GM-CSF genes, but not the IL-5, IL-6, and IL-10 genes, was strongly inhibited by cyclosporin A. Cyclosporine 127-140 interleukin 4 Mus musculus 36-40 8155595-9 1994 Cyclosporin A inhibited both the IL-4 promoter activity and activation of the inducible nuclear protein. Cyclosporine 0-13 interleukin 4 Mus musculus 33-37 7889406-1 1994 We show here that ligation of surface immunoglobulin or CD40 receptors in conjunction with interleukin-4 induces the nuclear factor of activated T cells (NF-AT) in normal murine B cells, which is inhibited by cyclosporin (CsA). Cyclosporine 209-220 interleukin 4 Mus musculus 91-104 7889406-1 1994 We show here that ligation of surface immunoglobulin or CD40 receptors in conjunction with interleukin-4 induces the nuclear factor of activated T cells (NF-AT) in normal murine B cells, which is inhibited by cyclosporin (CsA). Cyclosporine 222-225 interleukin 4 Mus musculus 91-104 8045668-0 1994 Effect of interferon-gamma, interleukin-2 and interleukin-4 on cyclosporin-A-mediated inhibition of anti-CD3-induced T-lymphocyte proliferation. Cyclosporine 63-76 interleukin 4 Mus musculus 46-59 8045668-4 1994 IL-2 and IL-4, in combination, were able to largely reverse the immunosuppressive activity of CsA. Cyclosporine 94-97 interleukin 4 Mus musculus 9-13 1538126-8 1992 IL-4 production could be inhibited by cyclosporin A and required extracellular calcium, whereas cell cycle arrest did not. Cyclosporine 38-51 interleukin 4 Mus musculus 0-4 7528676-7 1994 We previously reported that ligation of either sIg or CD40 receptors, in conjunction with IL-4, induces the transcription factor, nuclear factor of activated T cells (NF-AT) in B cells, via a CsA/FK506-sensitive pathway. Cyclosporine 192-195 interleukin 4 Mus musculus 90-94 2303747-8 1990 The addition of cyclosporin A (CsA) to cultures of 8-E and 8-5 clones together with antigen also resulted in the complete inhibition of cellular proliferation in association with the suppression of IL2 and IL4 production. Cyclosporine 16-29 interleukin 4 Mus musculus 206-209 1731346-3 1992 We have intervened prophylactically in RadLV-induced preleukemia by using cyclosporin-A (CSA), which inhibits IL-4 production, and an immunotoxin (ITx) that kills PL cells. Cyclosporine 74-87 interleukin 4 Mus musculus 110-114 1731346-3 1992 We have intervened prophylactically in RadLV-induced preleukemia by using cyclosporin-A (CSA), which inhibits IL-4 production, and an immunotoxin (ITx) that kills PL cells. Cyclosporine 89-92 interleukin 4 Mus musculus 110-114 1731346-4 1992 CSA efficiently inhibited IL-4 secretion from RadLV-induced PL and leukemic cells, and its administration to PL mice caused a significant delay in their death. Cyclosporine 0-3 interleukin 4 Mus musculus 26-30 1672640-0 1991 Interleukin 2/interleukin 4-independent T helper cell generation during an in vitro antigenic stimulation of mouse spleen cells in the presence of cyclosporin A. Cyclosporine 147-160 interleukin 4 Mus musculus 14-27 1672640-6 1991 Lymphokine genes transcription analysis confirms that the inhibition of interleukin (IL) 2/IL 4 gene expression is one target of CsA action. Cyclosporine 129-132 interleukin 4 Mus musculus 91-95 2173663-10 1990 This interpretation is supported by the findings that cyclosporin, which abrogates the activation of lymphocytes by Ca2(+)-dependent stimuli, inhibits B cell proliferation induced by anti-Ig plus IL4, but not the response to PBu2 plus IL4. Cyclosporine 54-65 interleukin 4 Mus musculus 196-199 2173663-10 1990 This interpretation is supported by the findings that cyclosporin, which abrogates the activation of lymphocytes by Ca2(+)-dependent stimuli, inhibits B cell proliferation induced by anti-Ig plus IL4, but not the response to PBu2 plus IL4. Cyclosporine 54-65 interleukin 4 Mus musculus 235-238 2142529-9 1990 Effects of cyclosporine A and the protein synthesis inhibitors cycloheximide and anisomycin on IL-4 and IL-5 gene expression suggest that these genes are activated by different pathways after anti-CD3 stimulation. Cyclosporine 11-25 interleukin 4 Mus musculus 95-99 2142529-10 1990 Cyclosporine A completely inhibited anti-CD3-induced expression of IL-4 mRNA but not of IL-5 mRNA, and protein-synthesis inhibitors completely inhibited induction of IL-5 mRNA but not of IL-4 mRNA. Cyclosporine 0-14 interleukin 4 Mus musculus 67-71 2303747-8 1990 The addition of cyclosporin A (CsA) to cultures of 8-E and 8-5 clones together with antigen also resulted in the complete inhibition of cellular proliferation in association with the suppression of IL2 and IL4 production. Cyclosporine 31-34 interleukin 4 Mus musculus 206-209 33764520-9 2021 CSA re-stimulated LN cells from vaccinated mice after challenge infection secreted comparable IL-4 and IL-10 but reduced IFN-gamma, as compared to controls. Cyclosporine 0-3 interleukin 4 Mus musculus 94-98 3262657-0 1988 IL-4 bypasses the immune suppressive effect of cyclosporin A during the in vitro induction of murine cytotoxic T lymphocytes. Cyclosporine 47-60 interleukin 4 Mus musculus 0-4 2499483-0 1989 Synergy between interleukin 4 and interleukin 2 conveys resistance to cyclosporin A during primary in vitro activation of murine CD8 cytotoxic T cell precursors. Cyclosporine 70-83 interleukin 4 Mus musculus 16-29 2499483-3 1989 Using an in vitro model system in which the requirement for antigen-presenting cells during primary activation of resting murine CD8 T cells is bypassed by immobilized anti-CD3 monoclonal antibodies, we here describe conditions in which IL 4 conveys CsA resistance to murine CD8 T cells triggered by immobilized anti-CD3 monoclonal antibodies to respond to IL 2. Cyclosporine 250-253 interleukin 4 Mus musculus 237-241 2499483-4 1989 CsA resistance of IL 4 and IL 2-responsive CD8 T cell parallels conditions in which signals provided by IL 4 and IL 2 synergize with each other. Cyclosporine 0-3 interleukin 4 Mus musculus 18-22 2499483-4 1989 CsA resistance of IL 4 and IL 2-responsive CD8 T cell parallels conditions in which signals provided by IL 4 and IL 2 synergize with each other. Cyclosporine 0-3 interleukin 4 Mus musculus 18-31 2499483-6 1989 In addition to the known pleiotropic effects of IL 4, our results define an IL 4-dependent, CsA-resistant signal pathway which allows CTL differentiation in the absence of significant cell proliferation. Cyclosporine 92-95 interleukin 4 Mus musculus 76-80 3262657-1 1988 We have analyzed at the clonal level the effect of IL-4 on the immune suppressive action of cyclosporin A (CsA) during the in vitro primary activation of anti-MHC alloantigen-reactive murine CD8+ CTL. Cyclosporine 92-105 interleukin 4 Mus musculus 51-55 3262657-1 1988 We have analyzed at the clonal level the effect of IL-4 on the immune suppressive action of cyclosporin A (CsA) during the in vitro primary activation of anti-MHC alloantigen-reactive murine CD8+ CTL. Cyclosporine 107-110 interleukin 4 Mus musculus 51-55 3114369-5 1987 Furthermore, inhibition of this proliferative response with an anti-IL 4 monoclonal antibody or cyclosporine indicated that IL 4 functions as an autocrine growth factor. Cyclosporine 96-108 interleukin 4 Mus musculus 124-128 3257564-4 1988 Cyclosporin A inhibited the synthesis of IL-4 mRNA in the T-cell line 2.19, which had been induced by concanavalin A. Cyclosporine 0-13 interleukin 4 Mus musculus 41-45 3133410-2 1988 This response of T cells to IL-4 plus PMA is independent of the action of IL-2 as judged by 1) the lack of IL-2 in supernatants of stimulated cells, 2) the failure to detect IL-2 mRNA in stimulated cells by in situ hybridization, 3) the inability of anti-IL-2R antibody and of anti-IL-2 antibody to block responses to IL-4 plus PMA, and 4) the failure of cyclosporin A to block responses. Cyclosporine 355-368 interleukin 4 Mus musculus 28-32 3489759-3 1986 We show that activation of resting B cells by B cell-stimulatory factor-1 (BSF-1) is resistant to CS, whereas stimulation by anti-Ig antibodies is not, which is in agreement with earlier findings. Cyclosporine 98-100 interleukin 4 Mus musculus 46-73 3489759-3 1986 We show that activation of resting B cells by B cell-stimulatory factor-1 (BSF-1) is resistant to CS, whereas stimulation by anti-Ig antibodies is not, which is in agreement with earlier findings. Cyclosporine 98-100 interleukin 4 Mus musculus 75-80 27309728-10 2016 The levels of TNF, IL-4, IL-5, and IL-13 were significantly decreased after treatment with cyclosporine. Cyclosporine 91-103 interleukin 4 Mus musculus 19-23 25452304-4 2015 In CsA-treated allograft recipient mice, CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) were functional suppressive immune modulators that resulted in fewer gamma interferon (IFN-gamma)-producing CD8(+) T cells and CD4(+) T cells (T(H)1 T helper cells) and more interleukin 4 (IL-4)-producing CD4(+) T cells (T(H2)) and prolonged allogeneic skin graft survival. Cyclosporine 3-6 interleukin 4 Mus musculus 272-285 25452304-4 2015 In CsA-treated allograft recipient mice, CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) were functional suppressive immune modulators that resulted in fewer gamma interferon (IFN-gamma)-producing CD8(+) T cells and CD4(+) T cells (T(H)1 T helper cells) and more interleukin 4 (IL-4)-producing CD4(+) T cells (T(H2)) and prolonged allogeneic skin graft survival. Cyclosporine 3-6 interleukin 4 Mus musculus 287-291