PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19249526-3	2009	We have reported herein the efficacy of divided administration of interferon (IFN) beta plus cyclosporine for chronic hepatitis C patients who failed pegylated (Peg)-IFN or IFN combined ribavirin treatment.	Cyclosporine	93-105	interferon alpha 1	Homo sapiens	166-176	
19467023-7	2009	Furthermore, we showed that fluvastatin or cyclosporine A in combination with IFN-alpha could prevent the relapse after therapy in the IFN-alpha-resistant HCV RNA-harboring cells.	Cyclosporine	43-57	interferon alpha 1	Homo sapiens	135-144	
17362315-0	2007	Phase II trial of carboplatin and infusional cyclosporine with alpha-interferon in recurrent ovarian cancer: a California Cancer Consortium Trial.	Cyclosporine	45-57	interferon alpha 1	Homo sapiens	63-79	
17376913-5	2007	This resistance is specific to CsA as the replicon cells most resistant to CsA were still sensitive to IFN-alpha and a polymerase inhibitor.	Cyclosporine	31-34	interferon alpha 1	Homo sapiens	103-112	
17376913-5	2007	This resistance is specific to CsA as the replicon cells most resistant to CsA were still sensitive to IFN-alpha and a polymerase inhibitor.	Cyclosporine	75-78	interferon alpha 1	Homo sapiens	103-112	
15498318-8	2004	The activity of NF-kappaB and IFN-gammamRNA expression were significantly inhibited in SD-to-Wistar + ciclosporin group which was significantly lower than that of SD-to-Wistar group (P < 0.001).	Cyclosporine	102-113	interferon alpha 1	Homo sapiens	30-33	
9568730-1	1998	A monoclonal antibody (mAb) directed against the extracellular domain of the IFNAR1 chain of the human interferon-alpha (IFN-alpha) receptor (IFN-alphaR), which inhibits activation of the Jak-Stat signal transduction pathway, administered together with a subeffective dose of cyclosporine induced prolonged survival of skin allografts in major histocompatibility complex (MHC) divergent cynomolgus monkeys.	Cyclosporine	276-288	interferon alpha 1	Homo sapiens	121-130	
10084328-7	1999	Conversely, IL-10 or IFN-alpha addition increases the inhibitory effect of CsA on the PR of PBMC from both HP and controls.	Cyclosporine	75-78	interferon alpha 1	Homo sapiens	21-30	
8073829-6	1994	Treatment with cyclosporin, acitretin and the Goeckerman regimen increased the total IFN activity, but did not affect the levels of IFNs nor TNF-alpha.	Cyclosporine	15-26	interferon alpha 1	Homo sapiens	85-88	
8000516-5	1994	The rationale for the use of low-dose IFN-alpha with cyclosporin A (CyA) is discussed.	Cyclosporine	53-66	interferon alpha 1	Homo sapiens	38-47	
8000516-5	1994	The rationale for the use of low-dose IFN-alpha with cyclosporin A (CyA) is discussed.	Cyclosporine	68-71	interferon alpha 1	Homo sapiens	38-47	
8322134-8	1993	Inhibition of IFN-alpha (IFN-alpha) synthesizing capacity may be part of the immunosuppression mechanism of action of cyclosporine in patients undergoing transplant.	Cyclosporine	118-130	interferon alpha 1	Homo sapiens	14-23	
8322134-8	1993	Inhibition of IFN-alpha (IFN-alpha) synthesizing capacity may be part of the immunosuppression mechanism of action of cyclosporine in patients undergoing transplant.	Cyclosporine	118-130	interferon alpha 1	Homo sapiens	25-34	
1827048-5	1991	IFN-alpha also inhibited the IFN-gamma-induced HLA-DR mRNA expression and showed synergy with CsA at low concentrations but not at high concentrations of the drugs.	Cyclosporine	94-97	interferon alpha 1	Homo sapiens	0-9	
1827048-6	1991	A common mechanistic element in the pathways of CsA and IFN-alpha is proposed.	Cyclosporine	48-51	interferon alpha 1	Homo sapiens	56-65	
2455682-3	1988	In order to investigate the effect of cyclosporin A (Cy A) on IFN systems in Behcet"s disease, 2-5AS activities of PBL from 2 patients under Cy A therapy (10 mg/kg/day) were examined.	Cyclosporine	53-57	interferon alpha 1	Homo sapiens	62-65	
2478451-5	1989	In the majority of patients with PAN or CSA, there was a marked increase in serum IFN-alpha and IL-2 levels, while TNF-alpha and IL-beta levels were moderately elevated.	Cyclosporine	40-43	interferon alpha 1	Homo sapiens	82-91	
2455682-5	1988	The effect of Cy A on the production of IFN by PBL in vitro was also examined.	Cyclosporine	14-18	interferon alpha 1	Homo sapiens	40-43	
2455682-6	1988	IFN synthesis was markedly suppressed by Cy A in patients and controls.	Cyclosporine	41-45	interferon alpha 1	Homo sapiens	0-3	
24196705-7	2013	Finally, we show that we can pharmacologically induce wild-type HIV-1 infection to stimulate IFN secretion and an antiviral state using a non-immunosuppressive cyclosporine analogue.	Cyclosporine	160-172	interferon alpha 1	Homo sapiens	93-96	
29501733-12	2018	(5) The autophagy inhibitor 3-MA inhibited CsA-induced TNF-alpha and IFN-alpha up-regulation and fibrosis.	Cyclosporine	43-46	interferon alpha 1	Homo sapiens	69-78	
27279606-7	2016	Interestingly, the infectivity of wild-type or P90A virus could be rescued from the MX2-independent IFN-alpha-induced blocks in THP-1 cells by treatment with cyclosporine (Cs) or its nonimmunosuppressive analogue SDZ-NIM811, indicating that Cs-sensitive host cell cyclophilins other than CypA contribute to the activity of IFN-alpha-induced blocks.	Cyclosporine	158-170	interferon alpha 1	Homo sapiens	100-109	
27279606-7	2016	Interestingly, the infectivity of wild-type or P90A virus could be rescued from the MX2-independent IFN-alpha-induced blocks in THP-1 cells by treatment with cyclosporine (Cs) or its nonimmunosuppressive analogue SDZ-NIM811, indicating that Cs-sensitive host cell cyclophilins other than CypA contribute to the activity of IFN-alpha-induced blocks.	Cyclosporine	158-170	interferon alpha 1	Homo sapiens	323-332	
27279606-7	2016	Interestingly, the infectivity of wild-type or P90A virus could be rescued from the MX2-independent IFN-alpha-induced blocks in THP-1 cells by treatment with cyclosporine (Cs) or its nonimmunosuppressive analogue SDZ-NIM811, indicating that Cs-sensitive host cell cyclophilins other than CypA contribute to the activity of IFN-alpha-induced blocks.	Cyclosporine	172-174	interferon alpha 1	Homo sapiens	100-109	
27279606-7	2016	Interestingly, the infectivity of wild-type or P90A virus could be rescued from the MX2-independent IFN-alpha-induced blocks in THP-1 cells by treatment with cyclosporine (Cs) or its nonimmunosuppressive analogue SDZ-NIM811, indicating that Cs-sensitive host cell cyclophilins other than CypA contribute to the activity of IFN-alpha-induced blocks.	Cyclosporine	241-243	interferon alpha 1	Homo sapiens	100-109	
23990993-7	2013	Additionally, CsA inhibited SOCS-1 expression (the key negative regulator of IFN-alpha/beta), but not SOCS-2 or SOCS-3.	Cyclosporine	14-17	interferon alpha 1	Homo sapiens	77-86