PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8139144-0 1994 [Effect of recombinant atrial natriuretic peptide (r-ANP) on ischemic and cyclosporine-induced kidney damage in rats]. Cyclosporine 74-86 natriuretic peptide A Rattus norvegicus 23-49 11768242-6 2001 Substantial increases in ANF and betaMHC gene expression were detected in the AngII treated animals, which were either attenuated or blocked with CsA treatment. Cyclosporine 146-149 natriuretic peptide A Rattus norvegicus 25-28 11023705-1 2000 In order to elucidate the involvement of the atrial natriuretic peptide (ANP) and its receptor (natriuretic peptide receptor; NPR) system in cyclosporine-induced nephrotoxicity, we investigated the cyclosporine A (CsA)-induced changes in characteristics of the NPR/guanylyl cyclase system in the glomerulus and inner medulla of the rat kidney. Cyclosporine 198-212 natriuretic peptide A Rattus norvegicus 45-71 11023705-7 2000 Direct application of CsA to normal glomerular membrane completely abolished the ANP-induced guanylyl cyclase activation. Cyclosporine 22-25 natriuretic peptide A Rattus norvegicus 81-84 11023705-8 2000 Binding studies, using(125)I-ANP, revealed that B(max)was decreased in the CsA group, while K(d)was not affected in the glomerulus. Cyclosporine 75-78 natriuretic peptide A Rattus norvegicus 29-32 11023705-12 2000 These results indicate that CsA impairs the guanylyl cyclase activity mainly in the glomerulus by the decrease in NPR population and/or by direct inhibition, suggesting that the ANP/NPR system might be involved in CsA-induced nephrotoxicity. Cyclosporine 28-31 natriuretic peptide A Rattus norvegicus 178-181 11023705-12 2000 These results indicate that CsA impairs the guanylyl cyclase activity mainly in the glomerulus by the decrease in NPR population and/or by direct inhibition, suggesting that the ANP/NPR system might be involved in CsA-induced nephrotoxicity. Cyclosporine 214-217 natriuretic peptide A Rattus norvegicus 178-181 10455158-4 1999 ANF alone had no effect but inhibited PE-induced increases in CSA by approximately 50%. Cyclosporine 62-65 natriuretic peptide A Rattus norvegicus 0-3 16612258-10 2006 The detrimental effects of CsA were associated with upregulation of myocardial atrial natriuretic peptide (ANP) mRNA expression, paradoxical activation of the renin-angiotensin system (RAS), induction of renal reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase, and overexpression of oxidative stress-induced transcription factor NRF2. Cyclosporine 27-30 natriuretic peptide A Rattus norvegicus 79-105 11548882-9 2001 Increased mRNA expression of atrial natriuretic factor by IGF-1 was inhibited by cyclosporine A (p < 0.01). Cyclosporine 81-95 natriuretic peptide A Rattus norvegicus 29-54 11548882-11 2001 The fact that elevated calcineurin activity and induced atrial natriuretic factor mRNA expression by IGF-1 were blocked by cyclosporine A further supports the hypothesis that calcineurin is critically involved in IGF-1-induced ARVM hypertrophy. Cyclosporine 123-137 natriuretic peptide A Rattus norvegicus 56-81 12899339-7 2001 It was also found that CsA slightly reduced the mRNA level of ANF gene in AngII-stimulated cardiomyocytes. Cyclosporine 23-26 natriuretic peptide A Rattus norvegicus 62-65 7800215-0 1994 Prevention of acute cyclosporin nephrotoxicity by verapamil and atrial natriuretic factor in the rat. Cyclosporine 20-31 natriuretic peptide A Rattus norvegicus 64-89 7800215-3 1994 The present experimental study investigates whether verapamil or atrial natriuretic factor (ANF) are able to prevent the nephrotoxicity of CsA. Cyclosporine 139-142 natriuretic peptide A Rattus norvegicus 65-90 7800215-3 1994 The present experimental study investigates whether verapamil or atrial natriuretic factor (ANF) are able to prevent the nephrotoxicity of CsA. Cyclosporine 139-142 natriuretic peptide A Rattus norvegicus 92-95 8428779-0 1993 Atrial natriuretic peptide blunts the cellular effects of cyclosporine in smooth muscle. Cyclosporine 58-70 natriuretic peptide A Rattus norvegicus 0-26 8428779-8 1993 ANP (5 x 10(-9) M) blocked the Ca2+ mobilization by angiotensin II (71 +/- 7 versus 69 +/- 7 nM, NS) and also completely inhibited the effect of angiotensin II in the presence of cyclosporine (77 +/- 5 versus 78 +/- 5 nM, NS). Cyclosporine 179-191 natriuretic peptide A Rattus norvegicus 0-3 2138899-0 1990 The beneficial effect of atrial natriuretic peptide on cyclosporine nephrotoxicity. Cyclosporine 55-67 natriuretic peptide A Rattus norvegicus 25-51 2138899-8 1990 Similar effects on renal hemodynamics and electrolyte excretion rates were detected after ANP administration in chronic CyA treatment. Cyclosporine 120-123 natriuretic peptide A Rattus norvegicus 90-93 25277512-10 2014 As a calcineurin-specific inhibitor, CsA inhibited (3)H-Leu incorporation, surface area, mRNA expressions of ANP, BNP, beta-MHC, CnAbeta and protein expression of CnAbeta of AngII-induced cardiomyocytes. Cyclosporine 37-40 natriuretic peptide A Rattus norvegicus 109-112 2522254-0 1989 Prevention of acute cyclosporine nephrotoxicity by atrial natriuretic factor after ischemia in the rat. Cyclosporine 20-32 natriuretic peptide A Rattus norvegicus 51-76 2522254-1 1989 The present experimental study investigates whether the atrial natriuretic factor (ANF) is able to prevent the nephrotoxic effects of cyclosporine infused after 30 min of warm renal ischemia in the rat. Cyclosporine 134-146 natriuretic peptide A Rattus norvegicus 56-81 2522254-1 1989 The present experimental study investigates whether the atrial natriuretic factor (ANF) is able to prevent the nephrotoxic effects of cyclosporine infused after 30 min of warm renal ischemia in the rat. Cyclosporine 134-146 natriuretic peptide A Rattus norvegicus 83-86 2522254-5 1989 Moreover, the natriuretic ANF effects remained unaffected by high plasma CsA peak levels: indeed, other parameters of renal function--urinary flow, urinary sodium concentration and excretion rates, and urinary sodium reabsorption and fractional excretion rates, were significantly increased in ANF alone or CsA/ANF groups. Cyclosporine 307-310 natriuretic peptide A Rattus norvegicus 26-29