PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9705263-5	1998	In single-cycle infection assays, nef-defective virions were partially resistant to cyclosporin A (CsA), a drug that inhibits the binding of CyPA to the HIV-1 Gag precursor and CyPA incorporation into virions.	Cyclosporine	84-97	Nef	Human immunodeficiency virus 1	34-37	
14747548-6	2004	However, transferring these amino acids to the C terminus of HIV-1 Nef is insufficient to induce cyclosporine resistance in HIV-1.	Cyclosporine	97-109	Nef	Human immunodeficiency virus 1	67-70	
15709044-1	2005	We have previously shown that human immunodeficiency virus type 1 (HIV-1) virions which have their own nef gene deleted and are trans complemented to contain HIV-2 or simian immunodeficiency virus (SIV) Nef become resistant to treatment with cyclosporin A.	Cyclosporine	242-255	Nef	Human immunodeficiency virus 1	103-106	
9705263-5	1998	In single-cycle infection assays, nef-defective virions were partially resistant to cyclosporin A (CsA), a drug that inhibits the binding of CyPA to the HIV-1 Gag precursor and CyPA incorporation into virions.	Cyclosporine	99-102	Nef	Human immunodeficiency virus 1	34-37	
9705263-10	1998	They further suggest that in addition to blocking the CyPA-Gag interaction, CsA can also inhibit HIV-1 replication through a novel mechanism involving suppression of Nef-directed enhancement of virus infectivity.	Cyclosporine	76-79	Nef	Human immunodeficiency virus 1	166-169	
9223476-11	1997	The findings also support the hypothesis that Nef and CyPA enhance HIV-1 infectivity through independent processes and demonstrate a mechanistic difference between reduction of HIV-1 infectivity by cyclosporin A and gag mutations that decrease HIV-1 incorporation of CyPA.	Cyclosporine	198-211	Nef	Human immunodeficiency virus 1	46-49