PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16103732-3 2005 In this study, using in vitro and in vivo models, we examined the effects of cyclosporine (CsA) and tacrolimus (TAC) on OPN mRNA and protein expression. Cyclosporine 77-89 secreted phosphoprotein 1 Mus musculus 120-123 19357716-1 2009 Osteopontin, a secreted glycoprotein has been implicated in several renal pathological conditions such as those due to ureteral obstruction, ischemia, and cyclosporine toxicity. Cyclosporine 155-167 secreted phosphoprotein 1 Mus musculus 0-11 12081566-0 2002 Effects of cyclosporine in osteopontin null mice. Cyclosporine 11-23 secreted phosphoprotein 1 Mus musculus 27-38 19965778-10 2010 The calcineurin inhibitor cyclosporin A or the novel NFAT blocker A-285222 prevented glucose-induced OPN expression. Cyclosporine 26-39 secreted phosphoprotein 1 Mus musculus 101-104 16103732-3 2005 In this study, using in vitro and in vivo models, we examined the effects of cyclosporine (CsA) and tacrolimus (TAC) on OPN mRNA and protein expression. Cyclosporine 91-94 secreted phosphoprotein 1 Mus musculus 120-123 16103732-4 2005 We also examined if CsA- and TAC-induced OPN expression is dependent on transforming growth factor (TGF)-beta expression. Cyclosporine 20-23 secreted phosphoprotein 1 Mus musculus 41-44 16103732-7 2005 The expression of OPN was also studied in CsA-treated PTE cells with and without anti-TGF-beta antibody. Cyclosporine 42-45 secreted phosphoprotein 1 Mus musculus 18-21 16103732-12 2005 OPN may contribute to the CsA- and TAC-induced nephrotoxicity in organ transplant recipients and the increased OPN expression might be mediated by TGF-beta. Cyclosporine 26-29 secreted phosphoprotein 1 Mus musculus 0-3