PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34109683-14 2021 We confirmed that CsA, NIF, and PHT reduced cytosolic calcium levels increased by TGF-beta, while CaCl2 enhanced the TGF-beta-up-regulated NR4A1 expression. Cyclosporine 18-21 nuclear receptor subfamily 4 group A member 1 Homo sapiens 139-144 11385620-4 2001 The expression of Nur77 in response to TG treatment is sensitive to cyclosporin A, implicating that activation of calcineurin is necessary for Nur77 expression. Cyclosporine 68-81 nuclear receptor subfamily 4 group A member 1 Homo sapiens 18-23 7831306-6 1995 We report here that CsA inhibits the TCR-mediated activation of Nur77 protein in T-cell hybridomas by blocking the DNA binding activity of Nur77 protein rather than its de novo synthesis. Cyclosporine 20-23 nuclear receptor subfamily 4 group A member 1 Homo sapiens 64-69 7831306-6 1995 We report here that CsA inhibits the TCR-mediated activation of Nur77 protein in T-cell hybridomas by blocking the DNA binding activity of Nur77 protein rather than its de novo synthesis. Cyclosporine 20-23 nuclear receptor subfamily 4 group A member 1 Homo sapiens 139-144 7831306-7 1995 We also show that CsA mediates its negative effects on the Nur77 DNA binding activity through the N-terminal region of the protein. Cyclosporine 18-21 nuclear receptor subfamily 4 group A member 1 Homo sapiens 59-64 7831306-8 1995 This complete inhibition of Nur77 protein DNA binding activity may explain how CsA interferes with TCR-mediated apoptosis. Cyclosporine 79-82 nuclear receptor subfamily 4 group A member 1 Homo sapiens 28-33 7930567-8 1994 Con A-induced activation of NGFI-B gene expression was not overcome by cyclosporin A or by 8Br-cAMP, but was partially prevented by dexamethasone. Cyclosporine 71-84 nuclear receptor subfamily 4 group A member 1 Homo sapiens 28-34 7565789-7 1995 CsA decreases both Nur77 protein levels and promoter activity, and the kinetics of CsA inhibition of apoptosis correlates with a decrease in Nur77 protein levels. Cyclosporine 0-3 nuclear receptor subfamily 4 group A member 1 Homo sapiens 19-24 7565789-7 1995 CsA decreases both Nur77 protein levels and promoter activity, and the kinetics of CsA inhibition of apoptosis correlates with a decrease in Nur77 protein levels. Cyclosporine 83-86 nuclear receptor subfamily 4 group A member 1 Homo sapiens 141-146 7565789-9 1995 In addition, Nur77 promoter deletion analysis revealed two RSRF (related to serum-responsive factor) binding sites, which can confer calcium and CsA sensitivity on a heterologous promoter. Cyclosporine 145-148 nuclear receptor subfamily 4 group A member 1 Homo sapiens 13-18 7981602-5 1994 Various inhibitors of TCR-mediated apoptosis, including cyclosporin A down-regulate the Nur77 DNA binding activity. Cyclosporine 56-69 nuclear receptor subfamily 4 group A member 1 Homo sapiens 88-93 24680679-9 2014 However, inhibition of the relocation of Nur77 to mitochondria via Cyclosporin A reversed the changes in membrane potential mediated by H2O2 and reduced myocardial cell injury. Cyclosporine 67-80 nuclear receptor subfamily 4 group A member 1 Homo sapiens 41-46