PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7565789-7	1995	CsA decreases both Nur77 protein levels and promoter activity, and the kinetics of CsA inhibition of apoptosis correlates with a decrease in Nur77 protein levels.	Cyclosporine	0-3	nuclear receptor subfamily 4 group A member 1	Homo sapiens	19-24	
11385620-4	2001	The expression of Nur77 in response to TG treatment is sensitive to cyclosporin A, implicating that activation of calcineurin is necessary for Nur77 expression.	Cyclosporine	68-81	nuclear receptor subfamily 4 group A member 1	Homo sapiens	18-23	
7565789-7	1995	CsA decreases both Nur77 protein levels and promoter activity, and the kinetics of CsA inhibition of apoptosis correlates with a decrease in Nur77 protein levels.	Cyclosporine	83-86	nuclear receptor subfamily 4 group A member 1	Homo sapiens	141-146	
7565789-9	1995	In addition, Nur77 promoter deletion analysis revealed two RSRF (related to serum-responsive factor) binding sites, which can confer calcium and CsA sensitivity on a heterologous promoter.	Cyclosporine	145-148	nuclear receptor subfamily 4 group A member 1	Homo sapiens	13-18	
7930567-8	1994	Con A-induced activation of NGFI-B gene expression was not overcome by cyclosporin A or by 8Br-cAMP, but was partially prevented by dexamethasone.	Cyclosporine	71-84	nuclear receptor subfamily 4 group A member 1	Homo sapiens	28-34	
7831306-6	1995	We report here that CsA inhibits the TCR-mediated activation of Nur77 protein in T-cell hybridomas by blocking the DNA binding activity of Nur77 protein rather than its de novo synthesis.	Cyclosporine	20-23	nuclear receptor subfamily 4 group A member 1	Homo sapiens	64-69	
7831306-6	1995	We report here that CsA inhibits the TCR-mediated activation of Nur77 protein in T-cell hybridomas by blocking the DNA binding activity of Nur77 protein rather than its de novo synthesis.	Cyclosporine	20-23	nuclear receptor subfamily 4 group A member 1	Homo sapiens	139-144	
7831306-7	1995	We also show that CsA mediates its negative effects on the Nur77 DNA binding activity through the N-terminal region of the protein.	Cyclosporine	18-21	nuclear receptor subfamily 4 group A member 1	Homo sapiens	59-64	
7831306-8	1995	This complete inhibition of Nur77 protein DNA binding activity may explain how CsA interferes with TCR-mediated apoptosis.	Cyclosporine	79-82	nuclear receptor subfamily 4 group A member 1	Homo sapiens	28-33	
7981602-5	1994	Various inhibitors of TCR-mediated apoptosis, including cyclosporin A down-regulate the Nur77 DNA binding activity.	Cyclosporine	56-69	nuclear receptor subfamily 4 group A member 1	Homo sapiens	88-93	
24680679-9	2014	However, inhibition of the relocation of Nur77 to mitochondria via Cyclosporin A reversed the changes in membrane potential mediated by H2O2 and reduced myocardial cell injury.	Cyclosporine	67-80	nuclear receptor subfamily 4 group A member 1	Homo sapiens	41-46	
34109683-14	2021	We confirmed that CsA, NIF, and PHT reduced cytosolic calcium levels increased by TGF-beta, while CaCl2 enhanced the TGF-beta-up-regulated NR4A1 expression.	Cyclosporine	18-21	nuclear receptor subfamily 4 group A member 1	Homo sapiens	139-144