PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11594953-7 2001 Interleukin 6 and IL-8 were increased by 10 microg/mL of CsA, whereas transforming growth factor beta, PIIIP, and total protein were unaffected. Cyclosporine 57-60 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 15178703-6 2004 Moreover, an inhibitory effect of cyclosporin A, an immunosuppressor that inhibits calcineurin activity, on IL-8 release and IL-8 mRNA expression was observed. Cyclosporine 34-47 C-X-C motif chemokine ligand 8 Homo sapiens 108-112 15178703-6 2004 Moreover, an inhibitory effect of cyclosporin A, an immunosuppressor that inhibits calcineurin activity, on IL-8 release and IL-8 mRNA expression was observed. Cyclosporine 34-47 C-X-C motif chemokine ligand 8 Homo sapiens 125-129 12393716-7 2003 By contrast, the induction of interleukin-8 was delayed and was found to be cyclosporine insensitive. Cyclosporine 76-88 C-X-C motif chemokine ligand 8 Homo sapiens 30-43 11966773-10 2002 Pharmacological drugs used in therapy of RA, such as cyclosporin and methotrexate, induced a fourfold increase of IL-17R mRNA expression and augmented the IL-17-stimulated IL-8 expression. Cyclosporine 53-64 C-X-C motif chemokine ligand 8 Homo sapiens 172-176 10973631-6 2000 FK506 and cyclosporin A suppressed the chemotactic activity of the supernatant in parallel to the suppression of interleukin-8 production by peripheral blood mononuclear cells. Cyclosporine 10-23 C-X-C motif chemokine ligand 8 Homo sapiens 113-126 9780210-7 1998 Ascomycin and cyclosporin A, inhibitors of the Ca2+-dependent phosphatase, calcineurin, also inhibited thapsigargin-induced IL-8 production. Cyclosporine 14-27 C-X-C motif chemokine ligand 8 Homo sapiens 124-128 10755555-0 2000 Association of glucocorticoids and cyclosporin A or rapamycin prevents E-selectin and IL-8 expression during LPS- and TNFalpha-mediated endothelial cell activation. Cyclosporine 35-48 C-X-C motif chemokine ligand 8 Homo sapiens 86-90 11450070-5 2000 The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC. Cyclosporine 22-35 C-X-C motif chemokine ligand 8 Homo sapiens 90-94 11132774-7 2000 However, only basal secretion of interleukin-8 in both undifferentiated and DMSO-differentiated U937 cells was significantly reduced by CsA at the highest concentration (200 ng/ mL). Cyclosporine 136-139 C-X-C motif chemokine ligand 8 Homo sapiens 33-46 11132774-8 2000 At therapeutic concentrations in vivo, CsA exerts a predominant effect on IL-8 secretion by human mononuclear phagocytes. Cyclosporine 39-42 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 9588080-0 1998 [Production of IL-8 by the THP-1 monocyte cell line is regulated differently by cyclosporin and retinoic acid]. Cyclosporine 80-91 C-X-C motif chemokine ligand 8 Homo sapiens 15-19 9738952-6 1998 On the other hand, tetrodotoxin (TTX) and cyclosporin A inhibited only the NaF-induced 45Ca2+ influx (IC50 = 21 mol/l and 28 mol/l, respectively). Cyclosporine 42-55 C-X-C motif chemokine ligand 8 Homo sapiens 75-78 9723955-13 1998 Cyclosporin A significantly stimulated RANTES production at 10(-6) M and IL-8 production at 10(-7) M and 10(-6) M. 5. Cyclosporine 0-13 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 9713630-7 1998 It was found that CsA inhibits basal secretion of TNF-alpha and IL-8 at 20 and 200 ng ml-1. Cyclosporine 18-21 C-X-C motif chemokine ligand 8 Homo sapiens 64-68 9687567-8 1998 Of the mRNAs tested, only those encoding monocyte chemotactic protein-1 (approximately 2-fold over basal) and interleukin-8 (approximately 6-fold over basal) are induced by histamine; both of these responses are suppressed by CsA and FK506. Cyclosporine 226-229 C-X-C motif chemokine ligand 8 Homo sapiens 110-123 9588080-7 1998 The aim of the experiment was to find out CsA effect and RA effect on production of IL-8 by THP-1 cell line. Cyclosporine 42-45 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 9588080-11 1998 It was found out that CsA inhibits IL-8 production by stimulated THP-1 monocyte cell line in dose dependence course. Cyclosporine 22-25 C-X-C motif chemokine ligand 8 Homo sapiens 35-39 9507569-7 1997 Exposure of cyclosporin A and dexamethasone almost completely inhibited the production of IL-6 and IL-8 after 24 hours of treatment. Cyclosporine 12-25 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 9749826-5 1998 The increase of IL-8 in astrocyte-rich cultures induced by acidosis was potentiated by treatment with glutamate, which enhanced the increase of cytosolic Ca2+ levels under acidosis, and was affected by extracellular Ca2+ conditions, by cyclosporine A, an inhibitor of calcineurin, and by trifluoperazine, an inhibitor of phospholipase A2. Cyclosporine 236-250 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 9349985-3 1997 The effects of cyclosporine A (CsA), tacrolimus (FK506), and dexamethasone (DEX) on cytokine-induced production of interleukin (IL)-8 in a human colonic cancer cell line (HT-29) were examined. Cyclosporine 31-34 C-X-C motif chemokine ligand 8 Homo sapiens 115-133 9349985-6 1997 CsA (1, 5, and 10ng/ml) significantly reduced IL-1 beta-induced IL-8 production (by 32%, 41%, and 48%, respectively), and reduced TNF alpha-induced IL-8 production (by 21%, 42%, and 50%, respectively). Cyclosporine 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 64-68 9349985-6 1997 CsA (1, 5, and 10ng/ml) significantly reduced IL-1 beta-induced IL-8 production (by 32%, 41%, and 48%, respectively), and reduced TNF alpha-induced IL-8 production (by 21%, 42%, and 50%, respectively). Cyclosporine 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 148-152 9349985-8 1997 The expression of IL-8 mRNA was also inhibited by CsA. Cyclosporine 50-53 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 9020523-0 1997 The effects of cyclosporin A, dexamethasone and other immunomodulatory drugs on induced expression of IL-3, IL-4 and IL-8 mRNA in a human mast cell line. Cyclosporine 15-28 C-X-C motif chemokine ligand 8 Homo sapiens 117-121 9020523-3 1997 Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4. Cyclosporine 50-53 C-X-C motif chemokine ligand 8 Homo sapiens 150-154 9020523-3 1997 Treatment of the cells with the immunosuppressant CsA at 10(-5) M produced a significant inhibition of ionomycin-induced expression of IL-3, IL-4 and IL-8 mRNA, and at 10(-6) M produced a significant inhibition of induced expression of IL-3 and IL-8 but not IL-4. Cyclosporine 50-53 C-X-C motif chemokine ligand 8 Homo sapiens 245-249 8193081-12 1994 Hydrocortisone and cyclosporin A showed similar inhibitory effects on PMA/LPS-increased IL-8 secretion from NHKs but had little effect of restoring IL-1 alpha. Cyclosporine 19-32 C-X-C motif chemokine ligand 8 Homo sapiens 88-92 8088360-3 1994 Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected. Cyclosporine 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 88-101 8088360-3 1994 Cyclosporine, calcitriol, calcipotriol or dithranol caused a dose-dependent decrease in interleukin-8 binding to cultured human keratinocytes, while interleukin-8 binding to granulocytes was not affected. Cyclosporine 0-12 C-X-C motif chemokine ligand 8 Homo sapiens 149-162 7531627-11 1995 They further suggest that interference with IL-8 production and/or that of other key chemokines may be an important mechanism underlying the therapeutic efficacy of tacrolimus, and other agents such as cyclosporin A, with similar molecular actions. Cyclosporine 202-215 C-X-C motif chemokine ligand 8 Homo sapiens 44-48 8077662-5 1994 Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation. Cyclosporine 13-26 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 1873480-5 1991 Therefore, we addressed the question of whether the clinical improvement of psoriatic patients during CsA therapy may be due to an inhibition of NAP-1/IL-8 production and secretion from monocytes. Cyclosporine 102-105 C-X-C motif chemokine ligand 8 Homo sapiens 145-150 8458381-4 1993 Furthermore, eosinophil production of IL-8 in the presence of calcium ionophore could be inhibited with the immunomodulating agent cyclosporin A and the protein synthesis inhibitor cycloheximide. Cyclosporine 131-144 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 8342895-9 1993 In addition, CSR-CSA cycle length correlated with LECT (r = 0.939, p < 0.001). Cyclosporine 17-20 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 8335079-6 1993 Furthermore, native IL-8 was found to specifically bind CsA, whereas biologically inactive analogs of CsA were not bound by IL-8. Cyclosporine 56-59 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 8335079-7 1993 Putative binding sites for CsA on IL-8 could be identified on the basis of structural similarities between IL-8 and cyclophilin. Cyclosporine 27-30 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 8335079-7 1993 Putative binding sites for CsA on IL-8 could be identified on the basis of structural similarities between IL-8 and cyclophilin. Cyclosporine 27-30 C-X-C motif chemokine ligand 8 Homo sapiens 107-111 8335079-9 1993 We conclude that the specific binding of CsA to IL-8 may explain some of the anti-inflammatory effects of CsA. Cyclosporine 41-44 C-X-C motif chemokine ligand 8 Homo sapiens 48-52 8335079-9 1993 We conclude that the specific binding of CsA to IL-8 may explain some of the anti-inflammatory effects of CsA. Cyclosporine 106-109 C-X-C motif chemokine ligand 8 Homo sapiens 48-52 8443122-1 1993 Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA). Cyclosporine 245-258 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 8443122-1 1993 Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA). Cyclosporine 260-263 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 1720306-0 1991 Induction of members of the IL-8/NAP-1 gene family in human T lymphocytes is suppressed by cyclosporin A. Cyclosporine 91-104 C-X-C motif chemokine ligand 8 Homo sapiens 28-32 1720306-0 1991 Induction of members of the IL-8/NAP-1 gene family in human T lymphocytes is suppressed by cyclosporin A. Cyclosporine 91-104 C-X-C motif chemokine ligand 8 Homo sapiens 33-38 1873480-5 1991 Therefore, we addressed the question of whether the clinical improvement of psoriatic patients during CsA therapy may be due to an inhibition of NAP-1/IL-8 production and secretion from monocytes. Cyclosporine 102-105 C-X-C motif chemokine ligand 8 Homo sapiens 151-155 19897783-5 2009 In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses. Cyclosporine 31-42 C-X-C motif chemokine ligand 8 Homo sapiens 178-182 23086953-7 2012 SIRT6 increases the nuclear levels of the Ca(2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), and cyclosporin A, a calcineurin inhibitor that reduces NFAT activity, reduces TNF and IL8 expression in SIRT6-overexpressing cells. Cyclosporine 129-142 C-X-C motif chemokine ligand 8 Homo sapiens 212-215 24819773-7 2014 Our data indicate that IL-8 induced NETosis is reduced by ascomycin and cyclosporine A, antagonists of the calcineurin pathway, but not following treatment with rapamycin, which utilizes the mTOR pathway. Cyclosporine 72-86 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 24819773-8 2014 The action of the G protein coupled receptor phospholipase C pathway appears to be essential for the induction of NETs by IL-8, as NETosis was diminished by treatment with either pertussis toxin, a G-protein inhibitor, the phospholipase C inhibitor, U73122, or staurosporine, an inhibitor of protein kinase C. The data regarding the calcineurin antagonists, ascomycin and cyclosporine A, open the possibility to therapeutically suppress or modulate NETosis. Cyclosporine 372-386 C-X-C motif chemokine ligand 8 Homo sapiens 122-126 22211698-0 2012 Interleukin-17- and protease-activated receptor 2-mediated production of CXCL1 and CXCL8 modulated by cyclosporine A, vitamin D3 and glucocorticoids in human keratinocytes. Cyclosporine 102-116 C-X-C motif chemokine ligand 8 Homo sapiens 83-88 22211698-4 2012 The SLIGKV-NH(2) -induced production of both CXCL1 and CXCL8 was markedly reduced by cyclosporine A. Cyclosporine 85-99 C-X-C motif chemokine ligand 8 Homo sapiens 55-60 16965524-8 2006 IL-1alpha, IL-1beta and IL-8, but not IL-6, were detected in GCF of CsA-treated patients, but none of them was significantly associated with gingival overgrowth. Cyclosporine 68-71 C-X-C motif chemokine ligand 8 Homo sapiens 24-28 19464389-5 2009 Immunosuppressants (dexamethasone and cyclosporin A) inhibited the TNF-alpha-elicited formation of IL-8, prostaglandin E(2) and CCL27, but did not affect formation of reactive species. Cyclosporine 38-51 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 16801185-12 2006 Serum interleukin -8 may be useful in assessing the therapeutic effects of cyclosporine A in hyperzincaemia and hypercalprotectinaemia. Cyclosporine 75-89 C-X-C motif chemokine ligand 8 Homo sapiens 6-20 16212625-7 2005 IL1-beta stimulated IL-8 production was significantly increased in rapidly growing hTBEC cultures (n = 8) treated with cyclosporin (p = 0.049). Cyclosporine 119-130 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 16212625-9 2005 Inhibition of hTBEC growth, stimulation of IL-8 production and long-term effects on mucociliary phenotype and intact multi-layered epithelium suggest that cyclosporin may have a direct toxic effect on airway epithelium after transplantation. Cyclosporine 155-166 C-X-C motif chemokine ligand 8 Homo sapiens 43-47