PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9839278-0	1998	CsA and FK506 up-regulate eNOS expression: role of reactive oxygen species and AP-1.	Cyclosporine	0-3	nitric oxide synthase 3	Bos taurus	26-30	
11369812-1	2001	BACKGROUND: We have reported previously that exposure of endothelial cells to cyclosporin A (CsA) may result in the regulation of specific genes, such as the endothelial nitric oxide synthase.	Cyclosporine	78-91	nitric oxide synthase 3	Bos taurus	158-191	
11369812-1	2001	BACKGROUND: We have reported previously that exposure of endothelial cells to cyclosporin A (CsA) may result in the regulation of specific genes, such as the endothelial nitric oxide synthase.	Cyclosporine	93-96	nitric oxide synthase 3	Bos taurus	158-191	
8853343-6	1996	This augmentation is correlated with a threefold increase in the endothelial constitutive NO synthase (ecNOS) transcript, which is time dependent and maximal at 24 h. The CsA-induced increase in ecNOS mRNA expression was blocked by actinomycin D but unaltered by cycloheximide.	Cyclosporine	171-174	nitric oxide synthase 3	Bos taurus	103-108	
8853343-6	1996	This augmentation is correlated with a threefold increase in the endothelial constitutive NO synthase (ecNOS) transcript, which is time dependent and maximal at 24 h. The CsA-induced increase in ecNOS mRNA expression was blocked by actinomycin D but unaltered by cycloheximide.	Cyclosporine	171-174	nitric oxide synthase 3	Bos taurus	195-200	
8853343-7	1996	Levels of ecNOS protein were also enhanced by CsA after 24 h. These data establish that NO synthesis is moderately enhanced in endothelial cells exposed to CsA for long periods of time and describe a new mode of regulating ecNOS gene expression.	Cyclosporine	46-49	nitric oxide synthase 3	Bos taurus	10-15	
8853343-7	1996	Levels of ecNOS protein were also enhanced by CsA after 24 h. These data establish that NO synthesis is moderately enhanced in endothelial cells exposed to CsA for long periods of time and describe a new mode of regulating ecNOS gene expression.	Cyclosporine	46-49	nitric oxide synthase 3	Bos taurus	223-228	
8853343-7	1996	Levels of ecNOS protein were also enhanced by CsA after 24 h. These data establish that NO synthesis is moderately enhanced in endothelial cells exposed to CsA for long periods of time and describe a new mode of regulating ecNOS gene expression.	Cyclosporine	156-159	nitric oxide synthase 3	Bos taurus	10-15	
8853343-7	1996	Levels of ecNOS protein were also enhanced by CsA after 24 h. These data establish that NO synthesis is moderately enhanced in endothelial cells exposed to CsA for long periods of time and describe a new mode of regulating ecNOS gene expression.	Cyclosporine	156-159	nitric oxide synthase 3	Bos taurus	223-228	
15383526-0	2004	Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae.	Cyclosporine	0-13	nitric oxide synthase 3	Bos taurus	51-84	
9839278-1	1998	Cyclosporine A (CsA) and FK506 increase endothelial nitric oxide synthase (eNOS) mRNA expression in cultured bovine aortic endothelial cells (BAEC).	Cyclosporine	0-14	nitric oxide synthase 3	Bos taurus	40-73	
9839278-1	1998	Cyclosporine A (CsA) and FK506 increase endothelial nitric oxide synthase (eNOS) mRNA expression in cultured bovine aortic endothelial cells (BAEC).	Cyclosporine	0-14	nitric oxide synthase 3	Bos taurus	75-79	
9839278-1	1998	Cyclosporine A (CsA) and FK506 increase endothelial nitric oxide synthase (eNOS) mRNA expression in cultured bovine aortic endothelial cells (BAEC).	Cyclosporine	16-19	nitric oxide synthase 3	Bos taurus	40-73	
9839278-1	1998	Cyclosporine A (CsA) and FK506 increase endothelial nitric oxide synthase (eNOS) mRNA expression in cultured bovine aortic endothelial cells (BAEC).	Cyclosporine	16-19	nitric oxide synthase 3	Bos taurus	75-79	
9839278-2	1998	CsA appears to increase eNOS mRNA levels mainly by increasing the rate of transcription, although a small contribution of mRNA stabilization could not be ruled out.	Cyclosporine	0-3	nitric oxide synthase 3	Bos taurus	24-28	
9839278-5	1998	This upregulation of eNOS mRNA by CsA or GO was abrogated by catalase.	Cyclosporine	34-37	nitric oxide synthase 3	Bos taurus	21-25	
9647467-0	1998	Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells.	Cyclosporine	61-75	nitric oxide synthase 3	Bos taurus	102-106	
9647467-2	1998	Cyclosporine A (CsA) increases eNOS mRNA expression in bovine cultured aortic endothelial cells (BAEC).	Cyclosporine	0-14	nitric oxide synthase 3	Bos taurus	31-35	
9647467-2	1998	Cyclosporine A (CsA) increases eNOS mRNA expression in bovine cultured aortic endothelial cells (BAEC).	Cyclosporine	16-19	nitric oxide synthase 3	Bos taurus	31-35	
9647467-3	1998	As some effects of CsA may be mediated by reactive oxygen species (ROS), present experiments were devoted to test the hypothesis that the CsA-induced eNOS up-regulation could be dependent on an increased synthesis of ROS.	Cyclosporine	138-141	nitric oxide synthase 3	Bos taurus	150-154	
9647467-11	1998	The effect of CsA on eNOS mRNA expression was abrogated by catalase, and superoxide dismutase (SOD).	Cyclosporine	14-17	nitric oxide synthase 3	Bos taurus	21-25	
9647467-12	1998	In contrast, the antioxidant PDTC augmented eNOS mRNA expression, both in basal conditions and in the presence of CsA.	Cyclosporine	114-117	nitric oxide synthase 3	Bos taurus	44-48	
9647467-17	1998	The present results support a role for ROS, particularly superoxide anion and hydrogen peroxide, as mediators of the CsA-induced eNOS mRNA up-regulation.	Cyclosporine	117-120	nitric oxide synthase 3	Bos taurus	129-133