PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24823913-2 2014 Cyclosporine A enhances the proliferation of gingival cells; however, the relationships of SHH to cyclosporine A or to cyclosporine A-enhanced gingival cell proliferation have not been described. Cyclosporine 98-112 sonic hedgehog signaling molecule Homo sapiens 91-94 33993101-0 2021 Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-gamma-Shh-BDNF pathway. Cyclosporine 0-13 sonic hedgehog signaling molecule Homo sapiens 98-101 33993101-3 2021 Here, we found that the immunosuppressant cyclosporin A (CsA) decreased the number of BrdU+, BrdU+/DCX+, BrdU+/NeuN + cells in the hippocampus, impaired learning and memory and inhibited protein levels of the shh signaling pathway, including Shh, Smo and Gli1. Cyclosporine 42-55 sonic hedgehog signaling molecule Homo sapiens 209-212 33993101-3 2021 Here, we found that the immunosuppressant cyclosporin A (CsA) decreased the number of BrdU+, BrdU+/DCX+, BrdU+/NeuN + cells in the hippocampus, impaired learning and memory and inhibited protein levels of the shh signaling pathway, including Shh, Smo and Gli1. Cyclosporine 42-55 sonic hedgehog signaling molecule Homo sapiens 242-245 33993101-3 2021 Here, we found that the immunosuppressant cyclosporin A (CsA) decreased the number of BrdU+, BrdU+/DCX+, BrdU+/NeuN + cells in the hippocampus, impaired learning and memory and inhibited protein levels of the shh signaling pathway, including Shh, Smo and Gli1. Cyclosporine 57-60 sonic hedgehog signaling molecule Homo sapiens 209-212 33993101-3 2021 Here, we found that the immunosuppressant cyclosporin A (CsA) decreased the number of BrdU+, BrdU+/DCX+, BrdU+/NeuN + cells in the hippocampus, impaired learning and memory and inhibited protein levels of the shh signaling pathway, including Shh, Smo and Gli1. Cyclosporine 57-60 sonic hedgehog signaling molecule Homo sapiens 242-245 25385493-0 2015 Role of Shh and TGF in cyclosporine-enhanced expression of collagen and alpha-SMA by gingival fibroblast. Cyclosporine 23-35 sonic hedgehog signaling molecule Homo sapiens 8-11 25385493-4 2015 The effect of Shh on CsA-induced alterations was further evaluated by the extra-supplement or inhibition of Shh or TGF-beta. Cyclosporine 21-24 sonic hedgehog signaling molecule Homo sapiens 14-17 25385493-4 2015 The effect of Shh on CsA-induced alterations was further evaluated by the extra-supplement or inhibition of Shh or TGF-beta. Cyclosporine 21-24 sonic hedgehog signaling molecule Homo sapiens 108-111 25385493-5 2015 RESULTS: Cyclosporine-A enhanced COL1, alpha-SMA, Shh and TGF-beta expressions in human gingival fibroblasts. Cyclosporine 9-23 sonic hedgehog signaling molecule Homo sapiens 50-53 25385493-6 2015 The exogenous Shh/TGF-beta augmented the expression of COL1 and alpha-SMA, and the Shh/TGF-beta inhibition suppressed the CsA-enhanced COL1 and alpha-SMA expressions. Cyclosporine 122-125 sonic hedgehog signaling molecule Homo sapiens 14-17 25385493-6 2015 The exogenous Shh/TGF-beta augmented the expression of COL1 and alpha-SMA, and the Shh/TGF-beta inhibition suppressed the CsA-enhanced COL1 and alpha-SMA expressions. Cyclosporine 122-125 sonic hedgehog signaling molecule Homo sapiens 83-86 25385493-9 2015 CONCLUSIONS: Shh, regulated by TGF-beta, mediates CsA-altered gingival matrix homeostasis. Cyclosporine 50-53 sonic hedgehog signaling molecule Homo sapiens 13-16 24823913-4 2014 RESULTS: In human gingival fibroblasts, cyclosporine A treatment increased the expression of SHH transcripts and SHH protein, and stimulated cell proliferation; the addition of cyclopamine, an SHH signaling inhibitor, suppressed cyclosporine A-enhanced cell proliferation. Cyclosporine 40-54 sonic hedgehog signaling molecule Homo sapiens 93-96 24823913-4 2014 RESULTS: In human gingival fibroblasts, cyclosporine A treatment increased the expression of SHH transcripts and SHH protein, and stimulated cell proliferation; the addition of cyclopamine, an SHH signaling inhibitor, suppressed cyclosporine A-enhanced cell proliferation. Cyclosporine 40-54 sonic hedgehog signaling molecule Homo sapiens 113-116 24823913-4 2014 RESULTS: In human gingival fibroblasts, cyclosporine A treatment increased the expression of SHH transcripts and SHH protein, and stimulated cell proliferation; the addition of cyclopamine, an SHH signaling inhibitor, suppressed cyclosporine A-enhanced cell proliferation. Cyclosporine 40-54 sonic hedgehog signaling molecule Homo sapiens 113-116 24823913-6 2014 CONCLUSION: Cyclosporine A up-regulates gingival SHH expression in vitro and in vivo, and the inhibition of the SHH pathway counteracts the stimulatory effect of cyclosporine A on gingival fibroblast proliferation. Cyclosporine 12-26 sonic hedgehog signaling molecule Homo sapiens 49-52 24823913-6 2014 CONCLUSION: Cyclosporine A up-regulates gingival SHH expression in vitro and in vivo, and the inhibition of the SHH pathway counteracts the stimulatory effect of cyclosporine A on gingival fibroblast proliferation. Cyclosporine 162-176 sonic hedgehog signaling molecule Homo sapiens 49-52 24823913-6 2014 CONCLUSION: Cyclosporine A up-regulates gingival SHH expression in vitro and in vivo, and the inhibition of the SHH pathway counteracts the stimulatory effect of cyclosporine A on gingival fibroblast proliferation. Cyclosporine 162-176 sonic hedgehog signaling molecule Homo sapiens 112-115 24823913-7 2014 Therefore, we suggest that SHH mediates a novel molecular mechanism for cyclosporine A-induced gingival complications. Cyclosporine 72-86 sonic hedgehog signaling molecule Homo sapiens 27-30 23922933-0 2013 Crosstalk between Shh and TGF-beta signaling in cyclosporine-enhanced cell proliferation in human gingival fibroblasts. Cyclosporine 48-60 sonic hedgehog signaling molecule Homo sapiens 18-21 23922933-5 2013 However, Shh pathway involvement in cyclosporine-enhanced gingival proliferation and the existence of crosstalk with the TGF-beta pathway remain unclear. Cyclosporine 36-48 sonic hedgehog signaling molecule Homo sapiens 9-12 23922933-6 2013 METHODOLOGY/PRINCIPAL FINDINGS: Cyclosporine enhanced mRNA and protein levels of TGF-beta and Shh in human gingival fibroblasts (RT-PCR and western blotting). Cyclosporine 32-44 sonic hedgehog signaling molecule Homo sapiens 94-97 23922933-7 2013 A TGF-beta pathway inhibitor mitigated cyclosporine-enhanced cell proliferation and an Shh pathway inhibitor attenuated cyclosporine-enhanced proliferation in fibroblasts (MTS assay and/or RT-PCR of PCNA). Cyclosporine 120-132 sonic hedgehog signaling molecule Homo sapiens 87-90 23922933-9 2013 The TGF-beta pathway inhibitor mitigated cyclosporine-upregulated Shh expression, but the Shh pathway inhibitor did not alter cyclosporine-upregulated TGF-beta expression. Cyclosporine 41-53 sonic hedgehog signaling molecule Homo sapiens 66-69 23922933-10 2013 CONCLUSIONS/SIGNIFICANCE: The TGF-beta and Shh pathways mediate cyclosporine-enhanced gingival fibroblast proliferation. Cyclosporine 64-76 sonic hedgehog signaling molecule Homo sapiens 43-46 23922933-11 2013 Exogenous TGF-beta increased Shh expression, and inhibition of TGF-beta signaling abrogated the cyclosporine-induced upregulation of Shh expression; however, TGF-beta expression appeared unchanged by enhanced or inhibited Shh signaling. Cyclosporine 96-108 sonic hedgehog signaling molecule Homo sapiens 133-136 23922933-11 2013 Exogenous TGF-beta increased Shh expression, and inhibition of TGF-beta signaling abrogated the cyclosporine-induced upregulation of Shh expression; however, TGF-beta expression appeared unchanged by enhanced or inhibited Shh signaling. Cyclosporine 96-108 sonic hedgehog signaling molecule Homo sapiens 133-136 23922933-12 2013 This is the first study demonstrating the role of Shh in cyclosporine-enhanced gingival cell proliferation; moreover, it defines a hierarchical crosstalk pattern in which TGF-beta regulates Shh in gingival fibroblasts. Cyclosporine 57-69 sonic hedgehog signaling molecule Homo sapiens 50-53 23922933-12 2013 This is the first study demonstrating the role of Shh in cyclosporine-enhanced gingival cell proliferation; moreover, it defines a hierarchical crosstalk pattern in which TGF-beta regulates Shh in gingival fibroblasts. Cyclosporine 57-69 sonic hedgehog signaling molecule Homo sapiens 190-193 23922933-13 2013 Understanding the regulation of cyclosporine-related Shh and TGF-beta signaling and crosstalk in gingival overgrowth will clarify the mechanism of cyclosporine-induced gingival enlargement and help develop targeted therapeutics for blocking these pathways, which can be applied in pre-clinical and clinical settings. Cyclosporine 32-44 sonic hedgehog signaling molecule Homo sapiens 53-56 23922933-13 2013 Understanding the regulation of cyclosporine-related Shh and TGF-beta signaling and crosstalk in gingival overgrowth will clarify the mechanism of cyclosporine-induced gingival enlargement and help develop targeted therapeutics for blocking these pathways, which can be applied in pre-clinical and clinical settings. Cyclosporine 147-159 sonic hedgehog signaling molecule Homo sapiens 53-56