PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33634990-0	2021	Cyclosporine modulates neutrophil functions via the SIRT6-HIF-1alpha-glycolysis axis to alleviate severe ulcerative colitis.	Cyclosporine	0-12	sirtuin 6	Homo sapiens	52-57	
23086953-7	2012	SIRT6 increases the nuclear levels of the Ca(2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), and cyclosporin A, a calcineurin inhibitor that reduces NFAT activity, reduces TNF and IL8 expression in SIRT6-overexpressing cells.	Cyclosporine	129-142	sirtuin 6	Homo sapiens	230-235	
33634990-8	2021	We also observed that CsA-induced functional alternation of neutrophils was initiated through suppressing SIRT6 expression, which is responsible for expression of the downstream signaling molecules (e.g., HIF-1alpha, PFKFB3) and PDK4 ubiquitination, leading to fueling neutrophil glycolysis and TCA cycle.	Cyclosporine	22-25	sirtuin 6	Homo sapiens	106-111	
33634990-10	2021	CONCLUSIONS: The data reveal a novel mechanism of CsA in alleviating ASUC by promoting neutrophil HIF-1alpha expression and restricting excessive neutrophil activation in a SIRT6-HIF-1alpha-glycolysis axis, suggesting SIRT6 as a candidate target for maintaining mucosal homeostasis and treating intestinal inflammation.	Cyclosporine	50-53	sirtuin 6	Homo sapiens	173-178	
33634990-10	2021	CONCLUSIONS: The data reveal a novel mechanism of CsA in alleviating ASUC by promoting neutrophil HIF-1alpha expression and restricting excessive neutrophil activation in a SIRT6-HIF-1alpha-glycolysis axis, suggesting SIRT6 as a candidate target for maintaining mucosal homeostasis and treating intestinal inflammation.	Cyclosporine	50-53	sirtuin 6	Homo sapiens	218-223