PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33089282-0	2020	[Effect of curcumin on TGF-beta1 /Smad3 pathway in rat gingival fibroblast treated with cyclosporine A].	Cyclosporine	88-102	SMAD family member 3	Rattus norvegicus	34-39	
34638597-7	2021	Furthermore, chrysin co-treatment diminished CsA-induced TGF-beta1 signaling pathways, decreasing Smad 3 phosphorylation which lead to a subsequent reduction in Snail expression.	Cyclosporine	45-48	SMAD family member 3	Rattus norvegicus	98-104	
26738448-0	2016	Cyclosporine A promotes cell proliferation, collagen and alpha-smooth muscle actin expressions in rat gingival fibroblasts by Smad3 activation and miR-29b suppression.	Cyclosporine	0-14	SMAD family member 3	Rattus norvegicus	126-131	
26738448-2	2016	The aim of this study is to investigate the effect of miR-29b and TGF-beta/Smad3 signaling in cyclosporine A-stimulated rat gingival fibroblasts.	Cyclosporine	94-108	SMAD family member 3	Rattus norvegicus	75-80	
26738448-5	2016	The effects of Smad3 and miR-29b on cyclosporine A-induced alterations were further determined by Smad3 knockdown and miR-29b overexpression using transient transfection experiments.	Cyclosporine	36-50	SMAD family member 3	Rattus norvegicus	15-20	
26738448-9	2016	In addition, the suppression of miR-29b upon cyclosporine A exposure was significantly elevated by Smad3 knockdown, whereas cyclosporine A-induced Smad3 activation was not altered by miR-29b overexpression.	Cyclosporine	45-59	SMAD family member 3	Rattus norvegicus	99-104	
26738448-5	2016	The effects of Smad3 and miR-29b on cyclosporine A-induced alterations were further determined by Smad3 knockdown and miR-29b overexpression using transient transfection experiments.	Cyclosporine	36-50	SMAD family member 3	Rattus norvegicus	98-103	
26738448-9	2016	In addition, the suppression of miR-29b upon cyclosporine A exposure was significantly elevated by Smad3 knockdown, whereas cyclosporine A-induced Smad3 activation was not altered by miR-29b overexpression.	Cyclosporine	124-138	SMAD family member 3	Rattus norvegicus	147-152	
26738448-10	2016	CONCLUSIONS: These results suggest that cyclosporine A promotes cell proliferation, collagen and alpha-SMA expressions in rat gingival fibroblasts by Smad3 activation and miR-29b suppression.	Cyclosporine	40-54	SMAD family member 3	Rattus norvegicus	150-155	
26738448-7	2016	TGF-beta1 mRNA and protein expressions were upregulated and phosphorylated Smad3 was activated by cyclosporine A treatment, while miR-29b expression was significantly suppressed.	Cyclosporine	98-112	SMAD family member 3	Rattus norvegicus	75-80	
26738448-8	2016	Moreover, Smad3 knockdown and miR-29b overexpression reversed cyclosporine A-enhanced cell proliferation, COL1 and alpha-SMA expressions in gingival fibroblasts.	Cyclosporine	62-76	SMAD family member 3	Rattus norvegicus	10-15	
21693312-5	2011	RESULTS: The administration of tranilast decreased the expression of TGF-beta1 and Smad3 by CsA-treated rats, whereas it increased both mRNA and protein levels of Smad7.	Cyclosporine	92-95	SMAD family member 3	Rattus norvegicus	83-88	
26598188-0	2015	[Effect of cyclosporine A on TGF-beta/Smad3 signaling in rat gingival fibroblasts].	Cyclosporine	11-25	SMAD family member 3	Rattus norvegicus	38-43	
26598188-1	2015	PURPOSE: The aim of the study was to investigate the effect of cyclosporine A (CsA) on TGF-beta/Smad3 signaling in rat gingival fibroblasts and to explore the mechanism of CsA induced gingival overgrowth.	Cyclosporine	63-77	SMAD family member 3	Rattus norvegicus	96-101	
26598188-1	2015	PURPOSE: The aim of the study was to investigate the effect of cyclosporine A (CsA) on TGF-beta/Smad3 signaling in rat gingival fibroblasts and to explore the mechanism of CsA induced gingival overgrowth.	Cyclosporine	79-82	SMAD family member 3	Rattus norvegicus	96-101	
26598188-9	2015	The protein syntheses of TGF-beta1, p-Smad3 and Collagen I were also increased by CsA stimulation.	Cyclosporine	82-85	SMAD family member 3	Rattus norvegicus	38-43	
26598188-10	2015	CONCLUSIONS: CsA may activate TGF-beta/Smad3 signaling pathway, thus promoting the proliferation and migration of rat gingival fibroblasts as well as collagen accumulation, which eventually lead to gingival overgrowth.	Cyclosporine	13-16	SMAD family member 3	Rattus norvegicus	39-44	
17161347-10	2006	In CsA-treated animals (alone and with pioglitazone), TGF-beta1 and Smad3 increased significantly.	Cyclosporine	3-6	SMAD family member 3	Rattus norvegicus	68-73	
16980029-14	2006	RESULTS: CsA and FK506 stimulated gene expression and protein production of TGF-beta1, smad2, and smad3, but inhibited expression of smad7 both in VSMC and in the transplanted kidney.	Cyclosporine	9-12	SMAD family member 3	Rattus norvegicus	98-103	
16980029-19	2006	CsA and FK506 can cause CAN, owing to up-regulated expression of smad2 and smad3, and down-regulation of smad7 expression.	Cyclosporine	0-3	SMAD family member 3	Rattus norvegicus	75-80