PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16791842-5 2006 Activation of caspase-3 by physiological concentrations of cellular agonists, including thrombin or CCK-8, is independent of rises in cytosolic calcium concentration but requires PKC activation, and is necessary for agonist-induced activation of the tyrosine kinases Btk and pp60src and for several cellular functions, including store-operated calcium entry, platelet aggregation, or pancreatic secretion. Sincalide 100-105 Bruton tyrosine kinase Homo sapiens 267-270