PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32819236-11 2021 DAS and DADS also induced cellcycle arrest in G0/G1 phase, which was supported by the downregulation of cyclin D1 and CDK4 and upregulation of CDK inhibitors p21WAF1/CIP1 and p27KIP1 in Caski cells. diallyl disulfide 8-12 cyclin D1 Homo sapiens 104-113 22739413-10 2012 RESULTS: The results suggests that DADS decreases the survival rate of androgen independent prostate cancer cells by modulating the expression of IGF system, which leads to inhibition of phosphorylation of Akt, thereby inhibits cell cycle progression and survival by lowering the expression of cyclin D1, NFkB and anti-apoptotic Bcl-2 molecule and increasing the level of pro-apoptotic (Bad and Bax) signaling molecules which leads to apoptosis. diallyl disulfide 35-39 cyclin D1 Homo sapiens 294-303