PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23442912-1	2013	Phosphatase and tensin-homolog deleted on chromosome 10 (PTEN) is a tumor-suppressor protein that regulates phosphatidylinositol 3-kinase (PI3-K) signaling by binding to the plasma membrane and hydrolyzing the 3" phosphate from phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) to form phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2).	phosphoinositide-3,4,5-triphosphate	272-283	phosphatase and tensin homolog	Homo sapiens	57-61	
23741314-0	2013	Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN/PI(3,4,5)P3 dependent pathway.	phosphoinositide-3,4,5-triphosphate	107-118	phosphatase and tensin homolog	Homo sapiens	102-106	
23741314-10	2013	Moreover, BPV(pic), a specific inhibitor of PTEN, elevated PI(3,4,5)P3 and ENaC activity in a manner similar to that of H2O2 in A6 cells.	phosphoinositide-3,4,5-triphosphate	59-70	phosphatase and tensin homolog	Homo sapiens	44-48	
21241890-1	2011	PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate.	phosphoinositide-3,4,5-triphosphate	114-149	phosphatase and tensin homolog	Homo sapiens	0-4	
16675164-2	2006	The balance between phosphoinositide 3-kinase (PI3K) and PTEN determines PI(3,4,5)P3 levels.	phosphoinositide-3,4,5-triphosphate	73-84	phosphatase and tensin homolog	Homo sapiens	57-61	
19896393-5	2009	Sustained production of PI(3,4,5)P(3) in B cells, achieved through conditional deletion of Pten, resulted in failed tolerance induction and abundant autoantibody production.	phosphoinositide-3,4,5-triphosphate	24-37	phosphatase and tensin homolog	Homo sapiens	91-95	
17786934-2	2007	PTEN encodes a lipid phosphatase that dephosphorylates phosphoinositide-3,4,5-triphosphate (PIP(3)), thereby counteracting mitogenic signaling pathways driven by phosphoinositol-3-kinases (PI3K).	phosphoinositide-3,4,5-triphosphate	55-90	phosphatase and tensin homolog	Homo sapiens	0-4	
14764604-2	2004	We show that the lipid phosphatase activity of PTEN mediates chemotaxis and that the sharp localization of PI(3,4,5)P3 requires localization of PTEN to the rear of the cell.	phosphoinositide-3,4,5-triphosphate	107-118	phosphatase and tensin homolog	Homo sapiens	144-148	
15249580-1	2004	The mammalian tumor suppressor, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), inhibits cell growth and survival by dephosphorylating phosphatidylinositol-(3,4,5)-trisphosphate (PI[3,4,5]P3).	phosphoinositide-3,4,5-triphosphate	197-208	phosphatase and tensin homolog	Homo sapiens	91-95	
14764604-6	2004	On the other hand, the localization of PTEN does not depend on its phosphatase activity, the actin cytoskeleton, or the intracellular level of PI(3,4,5)P3, suggesting that events controlling localization are upstream of phosphoinositide signaling.	phosphoinositide-3,4,5-triphosphate	143-154	phosphatase and tensin homolog	Homo sapiens	39-43	
12857747-3	2003	Binding of di-C8-phosphatidylinositol 4,5-P2 (PI(4,5)P2) to PTEN enhances phosphatase activity for monodispersed substrates, PI(3,4,5)P3 and PI(3,4)P2.	phosphoinositide-3,4,5-triphosphate	125-136	phosphatase and tensin homolog	Homo sapiens	60-64	
34314064-3	2021	SHIP2, alongside PI3K and PTEN, regulates PI(3,4,5)P3 levels at the plasma membrane and has been heavily implicated in serious diseases such as cancer and type 2 diabetes; however, many aspects of its regulation mechanism remain elusive.	phosphoinositide-3,4,5-triphosphate	42-53	phosphatase and tensin homolog	Homo sapiens	26-30	
33947796-1	2021	The dual-specificity phosphatase PTEN functions as a tumor suppressor by hydrolyzing PI(3,4,5)P3 to PI(4,5)P2 to inhibit PI3K-AKT signaling and cellular proliferation.	phosphoinositide-3,4,5-triphosphate	85-96	phosphatase and tensin homolog	Homo sapiens	33-37	
33947796-7	2021	This interaction bridged PTEN across the P-Rex2 surface, preventing PI(3,4,5)P3 hydrolysis.	phosphoinositide-3,4,5-triphosphate	68-79	phosphatase and tensin homolog	Homo sapiens	25-29	
29987362-1	2018	PTEN prevents tumor genesis by antagonizing the PI3 kinase/Akt pathway through D3 site phosphatase activity toward PI(3,4)P2 and PI(3,4,5)P3.	phosphoinositide-3,4,5-triphosphate	129-140	phosphatase and tensin homolog	Homo sapiens	0-4	
33931764-4	2022	This modification prevents the plasma membrane translocation of PTEN and reduces its phosphatase activity therefore accumulating PI(3,4,5)P3.	phosphoinositide-3,4,5-triphosphate	129-140	phosphatase and tensin homolog	Homo sapiens	64-68	
32111929-1	2020	PTEN, a 3-phosphatase of phosphoinositide, regulates asymmetric PI(3,4,5)P3 signaling for the anterior-posterior polarization and migration of motile cells.	phosphoinositide-3,4,5-triphosphate	64-75	phosphatase and tensin homolog	Homo sapiens	0-4	
32974612-4	2020	Our work demonstrates that through inhibition of PTEN activity, PRG2 stabilizes membrane PI(3,4,5)P3.	phosphoinositide-3,4,5-triphosphate	89-100	phosphatase and tensin homolog	Homo sapiens	49-53	
31722215-2	2019	We find that normal axon morphogenesis involves homeostasis of elongation and branch growth controlled by accumulation of PI(3,4,5)P3 through PTEN inhibition.	phosphoinositide-3,4,5-triphosphate	122-133	phosphatase and tensin homolog	Homo sapiens	142-146	
29987362-3	2018	Interestingly, PTEN shares remarkable homology to voltage-sensitive phosphatases (VSPs) that dephosphorylate D5 and D3 sites of PI(4,5)P2, PI(3,4)P2, and PI(3,4,5)P3.	phosphoinositide-3,4,5-triphosphate	154-165	phosphatase and tensin homolog	Homo sapiens	15-19	
29987362-8	2018	Combining TI/ET mutations with an A126G exchange in the active site removed major sequence variations between PTEN and VSPs and resulted in D5 activity toward PI(4,5)P2 and PI(3,4,5)P3 of PTENCiV.	phosphoinositide-3,4,5-triphosphate	173-184	phosphatase and tensin homolog	Homo sapiens	110-114	
29987362-10	2018	Importantly, the same combination of mutations also induced D5 activity toward PI(3,4,5)P3 in native PTEN demonstrating that the same residues determine the substrate specificity of the tumor suppressor in living cells.	phosphoinositide-3,4,5-triphosphate	79-90	phosphatase and tensin homolog	Homo sapiens	101-105	
29588397-4	2018	The signaling lipid phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3], which is dephosphorylated by phosphatase and tensin homolog (PTEN), is a potent tumorigenic signaling lipid.	phosphoinositide-3,4,5-triphosphate	64-75	phosphatase and tensin homolog	Homo sapiens	107-137	
29588397-4	2018	The signaling lipid phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3], which is dephosphorylated by phosphatase and tensin homolog (PTEN), is a potent tumorigenic signaling lipid.	phosphoinositide-3,4,5-triphosphate	64-75	phosphatase and tensin homolog	Homo sapiens	139-143	
29588397-7	2018	Furthermore, increased PI(3,4,5)P3 resulted in higher proportion of short-lived CCPs, an effect that recapitulates PTEN deletion.	phosphoinositide-3,4,5-triphosphate	23-34	phosphatase and tensin homolog	Homo sapiens	115-119	
27716613-5	2016	Just like the well-known tumor suppressor gene Phosphatase and Tensin Homolog (PTEN) it hydrolyses phosphatidylinositol (3,4,5) triphosphate (PI(3,4,5)P3).	phosphoinositide-3,4,5-triphosphate	142-153	phosphatase and tensin homolog	Homo sapiens	79-83	
29447222-0	2018	Kinetics of PTEN-mediated PI(3,4,5)P3 hydrolysis on solid supported membranes.	phosphoinositide-3,4,5-triphosphate	26-37	phosphatase and tensin homolog	Homo sapiens	12-16	
29447222-4	2018	One key enzyme that regulates PI(3,4,5)P3 levels at the plasma membrane is phosphatase and tensin homologue deleted on chromosome 10 (PTEN), which dephosphorylates PI(3,4,5)P3 through hydrolysis to form phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2).	phosphoinositide-3,4,5-triphosphate	30-41	phosphatase and tensin homolog	Homo sapiens	134-138	
29447222-4	2018	One key enzyme that regulates PI(3,4,5)P3 levels at the plasma membrane is phosphatase and tensin homologue deleted on chromosome 10 (PTEN), which dephosphorylates PI(3,4,5)P3 through hydrolysis to form phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2).	phosphoinositide-3,4,5-triphosphate	164-175	phosphatase and tensin homolog	Homo sapiens	134-138	
29447222-5	2018	It has been reported that PI(4,5)P2 is involved in positive feedback in the PI(3,4,5)P3 hydrolysis by PTEN.	phosphoinositide-3,4,5-triphosphate	76-87	phosphatase and tensin homolog	Homo sapiens	102-106	
29447222-8	2018	Here, we develop a fluorescent-protein biosensor approach to study how PI(3,4,5)P3 dephosphorylation is regulated by PTEN as well as its membrane-mediated feedback mechanisms.	phosphoinositide-3,4,5-triphosphate	71-82	phosphatase and tensin homolog	Homo sapiens	117-121	
29385737-1	2018	The tumor suppressor PTEN is a major homeostatic regulator, by virtue of its lipid phosphatase activity against phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3], which downregulates the PI3K/AKT/mTOR prosurvival signaling, as well as by its protein phosphatase activity towards specific protein targets.	phosphoinositide-3,4,5-triphosphate	154-165	phosphatase and tensin homolog	Homo sapiens	21-25	
25241900-2	2015	The tumor suppressor gene PTEN is deleted, mutated or hypermethylated in more than 60% of glioblastoma cases resulting in hyperactivation of the phosphoinositide 3-kinase pathway, which leads to sustained PI(3,4,5)P3 signaling, and thereby hyperactivation of Akt and other effectors.	phosphoinositide-3,4,5-triphosphate	205-216	phosphatase and tensin homolog	Homo sapiens	26-30	
26284192-1	2015	The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor suppressor has been for a long time attributed to its lipid phosphatase activity against PI(3,4,5)P3, the phospholipid product of the class I PI3Ks.	phosphoinositide-3,4,5-triphosphate	167-178	phosphatase and tensin homolog	Homo sapiens	61-65	
25461777-5	2015	These studies provide insights in the cellular regulation of PTEN, its interaction with PI(4,5)P2 in the inner plasma membrane and the pathway by which its substrate, PI(3,4,5)P3, accesses the PTEN catalytic site.	phosphoinositide-3,4,5-triphosphate	167-178	phosphatase and tensin homolog	Homo sapiens	61-65	
25461777-5	2015	These studies provide insights in the cellular regulation of PTEN, its interaction with PI(4,5)P2 in the inner plasma membrane and the pathway by which its substrate, PI(3,4,5)P3, accesses the PTEN catalytic site.	phosphoinositide-3,4,5-triphosphate	167-178	phosphatase and tensin homolog	Homo sapiens	193-197	
24958106-2	2014	PI3K catalyzes formation of phosphatidylinositol 3,4,5-triphosphate [PI(3,4,5)P3] after cell activation; PTEN subsequently reduces these lipids to basal levels.	phosphoinositide-3,4,5-triphosphate	69-80	phosphatase and tensin homolog	Homo sapiens	105-109	
24958106-6	2014	Our results show that PI3Ks dimerize in vivo and that PI3K and PTEN activities modulate each other in a complex that controls cell PI(3,4,5)P3 levels.	phosphoinositide-3,4,5-triphosphate	131-142	phosphatase and tensin homolog	Homo sapiens	63-67	
24744697-2	2014	PTEN is mainly present in the cytosol and transiently associates with the plasma membrane to dephosphorylate PI(3,4,5)P3, thereby antagonizing the PI3-Kinase signaling pathway.	phosphoinositide-3,4,5-triphosphate	109-120	phosphatase and tensin homolog	Homo sapiens	0-4	
24985344-1	2014	The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K).	phosphoinositide-3,4,5-triphosphate	128-139	phosphatase and tensin homolog	Homo sapiens	21-25