PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24091101-2	2014	The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.	phosphoinositide-3,4,5-triphosphate	138-149	inositol polyphosphate-5-phosphatase D	Homo sapiens	50-55	
23121445-2	2013	BACKGROUND: The SH2-containing inositol-5"-phosphatase 1 (SHIP1) metabolizes PI(3,4,5)P3 to PI(3,4)P2.	phosphoinositide-3,4,5-triphosphate	77-88	inositol polyphosphate-5-phosphatase D	Homo sapiens	16-56	
23551094-2	2013	SHIP1 removes the 5"-phosphate from the product of PI3K, PI(3,4,5)P3, to generate PI(3,4)P2.	phosphoinositide-3,4,5-triphosphate	57-68	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-5	
24069021-4	2013	Consequently, the 5"- and 3"-inositol poly-phosphatases SHIP1, SHIP2, and phosphatase and tensin homolog capable of targeting PI(3,4,5)P3 are potential genetic determinants of T cell effector functions in vivo.	phosphoinositide-3,4,5-triphosphate	126-137	inositol polyphosphate-5-phosphatase D	Homo sapiens	56-61	
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4,5-triphosphate	69-80	inositol polyphosphate-5-phosphatase D	Homo sapiens	47-58	
24069021-5	2013	In addition, the 5"-inositol poly-phosphatases SHIP1 and 2 can shunt PI(3,4,5)P3 to the rare but potent signaling phosphoinositide species PI(3,4)P2 and thus these SHIP1/2, and the INPP4A/B enzymes that deplete PI(3,4)P2 may have precise roles in T cell biology to amplify or inhibit effectors of PI3K signaling that are selectively recruited to and activated by PI(3,4)P2.	phosphoinositide-3,4,5-triphosphate	69-80	inositol polyphosphate-5-phosphatase D	Homo sapiens	164-171	
23121445-2	2013	BACKGROUND: The SH2-containing inositol-5"-phosphatase 1 (SHIP1) metabolizes PI(3,4,5)P3 to PI(3,4)P2.	phosphoinositide-3,4,5-triphosphate	77-88	inositol polyphosphate-5-phosphatase D	Homo sapiens	58-63	
17442886-8	2007	These results support a model in which phagosomal PI3K generates PI(3,4,5)P(3) necessary for later stages of phagocytosis, PTEN determines whether those late stages can occur, and SHIP-1 regulates when and where they occur by transiently suppressing PI(3,4,5)P(3)-dependent activities necessary for completion of phagocytosis.	phosphoinositide-3,4,5-triphosphate	250-263	inositol polyphosphate-5-phosphatase D	Homo sapiens	180-186	
21056081-2	2011	As a result, SHIP dampens down PI-3,4,5-P(3)-mediated signaling and represses the proliferation, differentiation, survival, activation, and migration of hematopoietic cells.	phosphoinositide-3,4,5-triphosphate	31-44	inositol polyphosphate-5-phosphatase D	Homo sapiens	13-17	
25723258-2	2015	By converting PI(3,4,5)P3 to PtdIns(3,4)P2 at the plasma membrane, SHIP1 modifies PI3-kinase mediated signaling.	phosphoinositide-3,4,5-triphosphate	14-25	inositol polyphosphate-5-phosphatase D	Homo sapiens	67-72	
12529653-7	2003	These results suggest a possible role of the mutated SHIP gene in the development of acute leukemia and chemotherapy resistance through the deregulation of the phosphatidylinositol-3,4,5-triphosphate (PI(3,4,5)P3)/Akt signaling pathway.	phosphoinositide-3,4,5-triphosphate	201-212	inositol polyphosphate-5-phosphatase D	Homo sapiens	53-57	
27760174-8	2016	Thus, our results illustrate the importance of BAR domain proteins in podosome structure and dynamics, and identify a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback mechanism that counterbalances Src and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption.	phosphoinositide-3,4,5-triphosphate	211-222	inositol polyphosphate-5-phosphatase D	Homo sapiens	136-141