PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27373828-8	2016	Treatment with 4-PBA considerably reduced the levels of BiP, IRE1alpha, and XBP1 in GCD2 cells; notably, 4-PBA treatment significantly reduced the levels of TGFBIp without change in TGFBI mRNA levels.	4-phenylbutyric acid	15-20	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	61-70	
35192143-9	2022	4-PBA treatment significantly hindered the expression of endoplasmic reticulum stress markers, such as PERK, ATF4, ATF6, p-eIF2alpha, IRE1, CHOP and XBP1, suggesting that the administration of 4-PBA was successful.	4-phenylbutyric acid	0-5	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	134-138	
23885834-10	2013	Finally, 4-phenylbutyric acid, a chemical chaperone that attenuates ER stress, blocks asbestos- and thapsigargin-induced AEC IRE-1 protein expression, but does not reduce ER Ca2(2+) release or apoptosis.	4-phenylbutyric acid	9-29	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	125-130	
22864750-5	2012	ER stress induced by thapsigargin was alleviated by 4-PBA through the regulation of several ER stress-inducible, unfolded protein response related proteins including GRP78, GRP94, C/EBP homologous protein, phospho-eIF-2alpha, eIF-2alpha, phospho-JNK1 (p46) and phospho-JNK2/3 (p54), JNK1, IRE-1alpha, PERK, and sXBP-1.	4-phenylbutyric acid	52-57	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	289-299	
34106769-6	2021	Likewise, 4-phenylbutyric acid inhibits ZIKV replication by attenuating the PERK and ATF6 pathways and potentiating the IRE1alpha pathway, suggesting that ZIKV infection is differentially and temporally regulated by different UPR arms.	4-phenylbutyric acid	10-30	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	120-129	
33651226-13	2021	4-PBA inhibits ER stress mainly through regulating PERK-ATF4-CHOP and IRE1-XBP1s branches.	4-phenylbutyric acid	0-5	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	70-74	
30055408-6	2018	4-phenylbutyric acid (4-PBA), an ER stress inhibitor, reduced the expression of IRE1alpha and NLRP1.	4-phenylbutyric acid	0-20	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	80-89	
30055408-6	2018	4-phenylbutyric acid (4-PBA), an ER stress inhibitor, reduced the expression of IRE1alpha and NLRP1.	4-phenylbutyric acid	22-27	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	80-89