PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34993544-7 2022 4-PBA attenuated TGF-beta1-induced p-eIF2alpha/eIF2alpha, CHOP, ROS generation and intergrin-beta3 expression. 4-phenylbutyric acid 0-5 DNA damage inducible transcript 3 Homo sapiens 58-62 34956386-6 2021 In addition, 4-phenylbutyric acid (4-PBA), the ER stress inhibitor, increased cell viability and decreased protein levels of GRP78 and CHOP, which is similar to PCB2, and thapsigargin (TG), the ER stress agonist, exhibited conversely meanwhile partly counteracted the hepatic protection of PCB2. 4-phenylbutyric acid 13-33 DNA damage inducible transcript 3 Homo sapiens 135-139 34956386-6 2021 In addition, 4-phenylbutyric acid (4-PBA), the ER stress inhibitor, increased cell viability and decreased protein levels of GRP78 and CHOP, which is similar to PCB2, and thapsigargin (TG), the ER stress agonist, exhibited conversely meanwhile partly counteracted the hepatic protection of PCB2. 4-phenylbutyric acid 35-40 DNA damage inducible transcript 3 Homo sapiens 135-139 29137257-7 2017 Indeed, blocking ER stress by 4-phenyl butyric acid (4-PBA) or knockdown of CCAAT/enhancer-binding protein homologous protein (CHOP) with siRNA alleviated kaempferol-induced HepG2 or Huh7 cells autophagy; while transfection with plasmid overexpressing CHOP reversed the effect of 4-PBA on kaempferol-induced autophagy. 4-phenylbutyric acid 280-285 DNA damage inducible transcript 3 Homo sapiens 76-125 33651226-13 2021 4-PBA inhibits ER stress mainly through regulating PERK-ATF4-CHOP and IRE1-XBP1s branches. 4-phenylbutyric acid 0-5 DNA damage inducible transcript 3 Homo sapiens 61-65 29137257-7 2017 Indeed, blocking ER stress by 4-phenyl butyric acid (4-PBA) or knockdown of CCAAT/enhancer-binding protein homologous protein (CHOP) with siRNA alleviated kaempferol-induced HepG2 or Huh7 cells autophagy; while transfection with plasmid overexpressing CHOP reversed the effect of 4-PBA on kaempferol-induced autophagy. 4-phenylbutyric acid 280-285 DNA damage inducible transcript 3 Homo sapiens 127-131 35192143-9 2022 4-PBA treatment significantly hindered the expression of endoplasmic reticulum stress markers, such as PERK, ATF4, ATF6, p-eIF2alpha, IRE1, CHOP and XBP1, suggesting that the administration of 4-PBA was successful. 4-phenylbutyric acid 0-5 DNA damage inducible transcript 3 Homo sapiens 140-144 29327364-6 2018 Downregulation of Bax/Bcl-2, CHOP, GRP78, inflammatory factors, and reactive oxygen species generation, and the increase of MMP level detected after 4-PBA treatment indicated an inhibitory effect of 4-PBA on cell apoptosis, inflammatory response, and ER stress in OA. 4-phenylbutyric acid 199-204 DNA damage inducible transcript 3 Homo sapiens 29-33 28712870-6 2017 Both CHOP and TFPI mRNA levels were upregulated after CC treatment, especially in the M2 phenotype, and the ER stress inhibitor 4-phenylbutyric acid (PBA) reversed this effect. 4-phenylbutyric acid 128-148 DNA damage inducible transcript 3 Homo sapiens 5-9 28063906-0 2017 Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2alpha-ATF4-CHOP pathway. 4-phenylbutyric acid 53-58 DNA damage inducible transcript 3 Homo sapiens 101-105 29142990-10 2017 Sodium 4-phenylbutyrate treatment increased COL4A5 transcript levels (P < 0.01), and reduced ER size (P < 0.01 by EM and P < 0.001 by immunostaining), ER stress (p HSPA5 and DDIT3, all P values < 0.01) and autophagy (ATG7, P < 0.01). 4-phenylbutyric acid 0-23 DNA damage inducible transcript 3 Homo sapiens 183-188 28270124-11 2017 Cyproterone acetate increases CHOP expression in a concentration and time-dependent manner and endoplasmic reticulum stress reducer 4-phenylbutyrate could block cyproterone acetate-induced CHOP and DR5 up-regulation. 4-phenylbutyric acid 132-148 DNA damage inducible transcript 3 Homo sapiens 189-193 27634458-6 2016 Treatments of SH-SY5Y cells with the chemical chaperone, 4-phenylbutyric acid and the ROS scavenger, N-acetyl-cysteine reduced the AA-induced expression of ATF4 protein and CHOP mRNA, and resulted in the suppression of apoptosis. 4-phenylbutyric acid 57-77 DNA damage inducible transcript 3 Homo sapiens 173-177 28039491-7 2016 Additionally, our in vitro study found that apoptotic rate was decreased with remarkable down-regulation of the cleaved caspase-12, CHOP, p-JNK after ER stress was inhibited by 4-Phenylbutyric acid (4-PBA) treatment. 4-phenylbutyric acid 177-197 DNA damage inducible transcript 3 Homo sapiens 132-136 27895089-7 2017 Moreover, HDL isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP upregulation, which were blocked by PBA and DPI. 4-phenylbutyric acid 154-157 DNA damage inducible transcript 3 Homo sapiens 113-117 26923251-12 2016 ASM siRNA, DES, recombinant AC, and ER stress inhibitor 4-phenylbutyric acid were blocked by elevated levels of C/EBP homologous protein (CHOP); ox-LDL induced elevated levels of CHOP. 4-phenylbutyric acid 56-76 DNA damage inducible transcript 3 Homo sapiens 112-136 27665710-7 2016 Inhibition of ER stress with 4-phenylbutyric acid effectively inhibited the activation of eIF2alpha and CHOP signals and reversed AGEs-induced cell apoptosis. 4-phenylbutyric acid 29-49 DNA damage inducible transcript 3 Homo sapiens 104-108 26923251-12 2016 ASM siRNA, DES, recombinant AC, and ER stress inhibitor 4-phenylbutyric acid were blocked by elevated levels of C/EBP homologous protein (CHOP); ox-LDL induced elevated levels of CHOP. 4-phenylbutyric acid 56-76 DNA damage inducible transcript 3 Homo sapiens 138-142 24551210-7 2014 Blocking ER stress using 4-phenylbutyric acid not only down-regulated AMP-induced GRP78 and CHOP expression, but also significantly decreased AMP-induced cell growth inhibition and apoptosis, whereas ER stress inducer thapsigargin played opposing effects. 4-phenylbutyric acid 25-45 DNA damage inducible transcript 3 Homo sapiens 92-96 26090483-5 2015 Interestingly, we discovered that 4-phenylbutyric acid (4-PBA), a selective inhibitor of ERS, blocked the apoptosis of BM-MSCs from SLE patients and alleviated the level of Jun N-terminal kinase1/2 (JNK1/2) and CHOP. 4-phenylbutyric acid 34-54 DNA damage inducible transcript 3 Homo sapiens 211-215 26090483-5 2015 Interestingly, we discovered that 4-phenylbutyric acid (4-PBA), a selective inhibitor of ERS, blocked the apoptosis of BM-MSCs from SLE patients and alleviated the level of Jun N-terminal kinase1/2 (JNK1/2) and CHOP. 4-phenylbutyric acid 56-61 DNA damage inducible transcript 3 Homo sapiens 211-215 24648941-8 2013 Sodium 4-phenylbutyrate (PBA), an ERS inhibitor, reduced CHOP and GRP78, as well as SNP-stimulated apoptosis of chondrocytes, without affecting the SNP-dependent generation of NO. 4-phenylbutyric acid 0-23 DNA damage inducible transcript 3 Homo sapiens 57-61 24416259-0 2014 4-Phenylbutyrate inhibits tunicamycin-induced acute kidney injury via CHOP/GADD153 repression. 4-phenylbutyric acid 0-16 DNA damage inducible transcript 3 Homo sapiens 75-82 24416259-8 2014 In vitro work showed that 4-PBA protected human proximal tubular cells from apoptosis and TM-induced CHOP expression, an ER stress inducible proapoptotic gene. 4-phenylbutyric acid 26-31 DNA damage inducible transcript 3 Homo sapiens 101-105 24416259-13 2014 When taken together, these results indicate that 4-PBA acts as an ER stress inhibitor, to partially protect the kidney from TM-induced AKI through the repression of ER stress-induced CHOP expression. 4-phenylbutyric acid 49-54 DNA damage inducible transcript 3 Homo sapiens 183-187 24648941-8 2013 Sodium 4-phenylbutyrate (PBA), an ERS inhibitor, reduced CHOP and GRP78, as well as SNP-stimulated apoptosis of chondrocytes, without affecting the SNP-dependent generation of NO. 4-phenylbutyric acid 25-28 DNA damage inducible transcript 3 Homo sapiens 57-61 16621797-8 2006 The inhibition of the major stress-inducible transcription factor CHOP (CCAAT/enhancer-binding protein homologous protein)/GADD153 together with bortezomib was most effective in repressing NFkappaB-mediated IL8 activation compared with interference of VCP, MLN-273 (proteasome inhibitor), or 4-phenylbutyrate (histone deacetylase inhibitor). 4-phenylbutyric acid 292-308 DNA damage inducible transcript 3 Homo sapiens 66-70