PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30293573-0 2018 Chemical chaperone 4-phenylbutyric acid alleviates the aggregation of human familial pulmonary fibrosis-related mutant SP-A2 protein in part through effects on GRP78. 4-phenylbutyric acid 19-39 heat shock protein family A (Hsp70) member 5 Homo sapiens 160-165 33983562-8 2021 SA and OA significantly induced GRP78, p-PERK, and p-eIF2alpha expressions from 24 to 72 h. 4-phenylbutyric acid (PBA) alleviated ER stress induced by SA. 4-phenylbutyric acid 92-112 heat shock protein family A (Hsp70) member 5 Homo sapiens 32-37 31416082-14 2019 CSE treatment significantly increased the expression of GRP78, IRE1, XBP-1 and ATF6 at the protein level at 48 h. Pretreatment with TG enhanced, whereas pretreatment with 4-PBA inhibited, the CSE-induced expression of alpha-SMA, GRP78 and XBP-1. 4-phenylbutyric acid 171-176 heat shock protein family A (Hsp70) member 5 Homo sapiens 56-61 31416082-14 2019 CSE treatment significantly increased the expression of GRP78, IRE1, XBP-1 and ATF6 at the protein level at 48 h. Pretreatment with TG enhanced, whereas pretreatment with 4-PBA inhibited, the CSE-induced expression of alpha-SMA, GRP78 and XBP-1. 4-phenylbutyric acid 171-176 heat shock protein family A (Hsp70) member 5 Homo sapiens 229-234 30293573-9 2018 The up-regulation expression of GRP78 might partially contribute to the aggregate-alleviating effect of 4-PBA. 4-phenylbutyric acid 104-109 heat shock protein family A (Hsp70) member 5 Homo sapiens 32-37 29481792-4 2018 The inhibitory role of fasudil in neutrophil chemotaxis was mediated by down-regulation of the chaperone glucose-regulated protein 78 (GRP78), since the inhibition was abolished by 4-phenyl butyric acid (a chemical chaperone mimicking GRP78). 4-phenylbutyric acid 181-202 heat shock protein family A (Hsp70) member 5 Homo sapiens 105-133 29327364-6 2018 Downregulation of Bax/Bcl-2, CHOP, GRP78, inflammatory factors, and reactive oxygen species generation, and the increase of MMP level detected after 4-PBA treatment indicated an inhibitory effect of 4-PBA on cell apoptosis, inflammatory response, and ER stress in OA. 4-phenylbutyric acid 199-204 heat shock protein family A (Hsp70) member 5 Homo sapiens 35-40 29481792-4 2018 The inhibitory role of fasudil in neutrophil chemotaxis was mediated by down-regulation of the chaperone glucose-regulated protein 78 (GRP78), since the inhibition was abolished by 4-phenyl butyric acid (a chemical chaperone mimicking GRP78). 4-phenylbutyric acid 181-202 heat shock protein family A (Hsp70) member 5 Homo sapiens 135-140 29481792-4 2018 The inhibitory role of fasudil in neutrophil chemotaxis was mediated by down-regulation of the chaperone glucose-regulated protein 78 (GRP78), since the inhibition was abolished by 4-phenyl butyric acid (a chemical chaperone mimicking GRP78). 4-phenylbutyric acid 181-202 heat shock protein family A (Hsp70) member 5 Homo sapiens 235-240 29393386-6 2018 4-PBA decreased GRP78 and p-eIF2alpha protein expression levels. 4-phenylbutyric acid 0-5 heat shock protein family A (Hsp70) member 5 Homo sapiens 16-21 27373828-8 2016 Treatment with 4-PBA considerably reduced the levels of BiP, IRE1alpha, and XBP1 in GCD2 cells; notably, 4-PBA treatment significantly reduced the levels of TGFBIp without change in TGFBI mRNA levels. 4-phenylbutyric acid 15-20 heat shock protein family A (Hsp70) member 5 Homo sapiens 56-59 28500249-7 2017 The administration of 4-phenyl butyrate (PBA), a chemical chaperone of protein folding and UPR activator, in the offspring from postnatal day 4 significantly reduced their body weight, fat deposition, which were in association with increased activating transcription factor (ATF)4, immunoglobulin-binding protein (BiP) and Erdj4 mRNA as well as reduced Parkin, PTEN-induced putative kinase (PINK)1 and dynamin-related protein (Drp)1 protein expression levels. 4-phenylbutyric acid 22-39 heat shock protein family A (Hsp70) member 5 Homo sapiens 282-312 28500249-7 2017 The administration of 4-phenyl butyrate (PBA), a chemical chaperone of protein folding and UPR activator, in the offspring from postnatal day 4 significantly reduced their body weight, fat deposition, which were in association with increased activating transcription factor (ATF)4, immunoglobulin-binding protein (BiP) and Erdj4 mRNA as well as reduced Parkin, PTEN-induced putative kinase (PINK)1 and dynamin-related protein (Drp)1 protein expression levels. 4-phenylbutyric acid 22-39 heat shock protein family A (Hsp70) member 5 Homo sapiens 314-317 28500249-7 2017 The administration of 4-phenyl butyrate (PBA), a chemical chaperone of protein folding and UPR activator, in the offspring from postnatal day 4 significantly reduced their body weight, fat deposition, which were in association with increased activating transcription factor (ATF)4, immunoglobulin-binding protein (BiP) and Erdj4 mRNA as well as reduced Parkin, PTEN-induced putative kinase (PINK)1 and dynamin-related protein (Drp)1 protein expression levels. 4-phenylbutyric acid 41-44 heat shock protein family A (Hsp70) member 5 Homo sapiens 282-312 28500249-7 2017 The administration of 4-phenyl butyrate (PBA), a chemical chaperone of protein folding and UPR activator, in the offspring from postnatal day 4 significantly reduced their body weight, fat deposition, which were in association with increased activating transcription factor (ATF)4, immunoglobulin-binding protein (BiP) and Erdj4 mRNA as well as reduced Parkin, PTEN-induced putative kinase (PINK)1 and dynamin-related protein (Drp)1 protein expression levels. 4-phenylbutyric acid 41-44 heat shock protein family A (Hsp70) member 5 Homo sapiens 314-317 29142990-10 2017 Sodium 4-phenylbutyrate treatment increased COL4A5 transcript levels (P < 0.01), and reduced ER size (P < 0.01 by EM and P < 0.001 by immunostaining), ER stress (p HSPA5 and DDIT3, all P values < 0.01) and autophagy (ATG7, P < 0.01). 4-phenylbutyric acid 0-23 heat shock protein family A (Hsp70) member 5 Homo sapiens 173-178 26307968-7 2015 Furthermore, treating the cells with the ER stress inhibitors 4-phenylbutyrate (4-PBA) or knocking down CHOP, using lentivirus encoded short hairpin interfering RNAs (shRNAs), significantly diminished the ZEA-induced increases in GRP78 and CHOP, and cell death. 4-phenylbutyric acid 62-78 heat shock protein family A (Hsp70) member 5 Homo sapiens 230-235 24648941-8 2013 Sodium 4-phenylbutyrate (PBA), an ERS inhibitor, reduced CHOP and GRP78, as well as SNP-stimulated apoptosis of chondrocytes, without affecting the SNP-dependent generation of NO. 4-phenylbutyric acid 0-23 heat shock protein family A (Hsp70) member 5 Homo sapiens 66-71 24648941-8 2013 Sodium 4-phenylbutyrate (PBA), an ERS inhibitor, reduced CHOP and GRP78, as well as SNP-stimulated apoptosis of chondrocytes, without affecting the SNP-dependent generation of NO. 4-phenylbutyric acid 25-28 heat shock protein family A (Hsp70) member 5 Homo sapiens 66-71 18285607-9 2008 A subset of 4-PBA-modulated ER-associated degradation chaperones (GRP94, HSP84, GRP78, GRP75, and GRP58) was observed to associate with the immature B form of CFTR in ER. 4-phenylbutyric acid 12-17 heat shock protein family A (Hsp70) member 5 Homo sapiens 80-85 15572843-9 2004 The tunicamycin-induced up-regulation of GRP78 and GRP94 and phosphorylation of PERK was suppressed by treatment with 4-PBA, indicating that 4-PBA suppresses ER stress responses by decreasing unfolded protein. 4-phenylbutyric acid 118-123 heat shock protein family A (Hsp70) member 5 Homo sapiens 41-46 15572843-9 2004 The tunicamycin-induced up-regulation of GRP78 and GRP94 and phosphorylation of PERK was suppressed by treatment with 4-PBA, indicating that 4-PBA suppresses ER stress responses by decreasing unfolded protein. 4-phenylbutyric acid 141-146 heat shock protein family A (Hsp70) member 5 Homo sapiens 41-46 24551210-7 2014 Blocking ER stress using 4-phenylbutyric acid not only down-regulated AMP-induced GRP78 and CHOP expression, but also significantly decreased AMP-induced cell growth inhibition and apoptosis, whereas ER stress inducer thapsigargin played opposing effects. 4-phenylbutyric acid 25-45 heat shock protein family A (Hsp70) member 5 Homo sapiens 82-87 22864750-5 2012 ER stress induced by thapsigargin was alleviated by 4-PBA through the regulation of several ER stress-inducible, unfolded protein response related proteins including GRP78, GRP94, C/EBP homologous protein, phospho-eIF-2alpha, eIF-2alpha, phospho-JNK1 (p46) and phospho-JNK2/3 (p54), JNK1, IRE-1alpha, PERK, and sXBP-1. 4-phenylbutyric acid 52-57 heat shock protein family A (Hsp70) member 5 Homo sapiens 166-171 34956386-6 2021 In addition, 4-phenylbutyric acid (4-PBA), the ER stress inhibitor, increased cell viability and decreased protein levels of GRP78 and CHOP, which is similar to PCB2, and thapsigargin (TG), the ER stress agonist, exhibited conversely meanwhile partly counteracted the hepatic protection of PCB2. 4-phenylbutyric acid 13-33 heat shock protein family A (Hsp70) member 5 Homo sapiens 125-130 34956386-6 2021 In addition, 4-phenylbutyric acid (4-PBA), the ER stress inhibitor, increased cell viability and decreased protein levels of GRP78 and CHOP, which is similar to PCB2, and thapsigargin (TG), the ER stress agonist, exhibited conversely meanwhile partly counteracted the hepatic protection of PCB2. 4-phenylbutyric acid 35-40 heat shock protein family A (Hsp70) member 5 Homo sapiens 125-130