PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31814524-7	2020	Knockdown of IL-8 partially prevented 4-PBA-induced-EMT by blocking the activation of the downstream Gab2-ERK pathway.	4-phenylbutyric acid	38-43	mitogen-activated protein kinase 1	Homo sapiens	106-109	
31814524-9	2020	Therefore, the results of this study demonstrated that 4-PBA-mediated inhibition of HDAC activity could induce EMT in gastric cancer cells via acetyl-histone-mediated IL-8 upregulation, and the downstream Gab2/ERK activation.	4-phenylbutyric acid	55-60	mitogen-activated protein kinase 1	Homo sapiens	210-213	
29913144-0	2018	Paraquat toxicity is attenuated by 4-phenylbutyrate-induced phosphorylation of ERK2 via PI3K in A549 cells.	4-phenylbutyric acid	35-51	mitogen-activated protein kinase 1	Homo sapiens	79-83	
15389886-6	2004	We observed activation of JNK and ERK by PB in the lung cancer cells.	4-phenylbutyric acid	41-43	mitogen-activated protein kinase 1	Homo sapiens	34-37	
28851073-6	2018	Upregulation of HER3/HER4 and activation of HER3/HER4-ERK pathway was shown to be involved in 4-PBA-induced gastric cancer cell migration.	4-phenylbutyric acid	94-99	mitogen-activated protein kinase 1	Homo sapiens	54-57	
28851073-8	2018	Consistently, the ERK inhibitor PD98059 also partially prevented 4-PBA-induced cell migration.	4-phenylbutyric acid	65-70	mitogen-activated protein kinase 1	Homo sapiens	18-21	
28851073-10	2018	These results demonstrate that 4-PBA promotes gastric cancer cells migration through upregulation of HER3/HER4 subsequent to increased levels of acetyl-histone and activation of ERK signaling.	4-phenylbutyric acid	31-36	mitogen-activated protein kinase 1	Homo sapiens	178-181