PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22961085-6	2013	In embryos cultured under high-glucose conditions (20 mmol/L), the use of 4-phenylbutyric acid (4-PBA), an ER chemical chaperone, diminished ER stress markers and abolished the activation of JNK1/2 and its downstream transcription factors, caspase 3 and caspase 8, and Sox1 neural progenitor apoptosis.	4-phenylbutyric acid	74-94	caspase 3	Homo sapiens	240-249	
22961085-6	2013	In embryos cultured under high-glucose conditions (20 mmol/L), the use of 4-phenylbutyric acid (4-PBA), an ER chemical chaperone, diminished ER stress markers and abolished the activation of JNK1/2 and its downstream transcription factors, caspase 3 and caspase 8, and Sox1 neural progenitor apoptosis.	4-phenylbutyric acid	96-101	caspase 3	Homo sapiens	240-249	
21804221-7	2011	EC-SOD enhancer 4-phenyl butyric acid also suppressed the caspase-3 activation.	4-phenylbutyric acid	16-37	caspase 3	Homo sapiens	58-67	
27578021-8	2017	In SH-SY5Y, ER stress inhibition by 4-phenylbutyric acid reduced UCB-induced apoptosis and decreased the cleaved forms of caspase-3 and PARP proteins.	4-phenylbutyric acid	36-56	caspase 3	Homo sapiens	122-131	
19724885-8	2009	Furthermore, 4-phenylbutyric acid, an inhibitor of UPR, partly reduced cell apoptosis and activation of caspase-3.	4-phenylbutyric acid	13-33	caspase 3	Homo sapiens	104-113	
17487363-6	2007	4-PB induced increased expression of genes of DNA damage checkpoints and of apoptosis via the down-regulation of anti-apoptotic bcl-2 mRNA expression and up-regulation of the activity of the apoptosis-associated enzyme caspase-3/7.	4-phenylbutyric acid	0-4	caspase 3	Homo sapiens	219-228