PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11595704-12 2001 Multidrug resistance-reversing agents, such as ONO-1078 and MK571, that directly interact and inhibit the transporting activity of MRP1 may be useful for treating ATL patients. pranlukast 47-55 ATP binding cassette subfamily C member 1 Homo sapiens 131-135 9751271-2 1998 We examined the effect of ONO-1078 on the sensitivity to vincristine (VCR) of MRP overexpressing multidrug-resistant CV60 and its parental drug-sensitive KB-3-1 cell lines. pranlukast 26-34 ATP binding cassette subfamily C member 1 Homo sapiens 78-81 9751271-8 1998 These findings suggest that ONO-1078 inhibits the transporting activity of MRP and that ONO-1078 increases the sensitivity to VCR of KB-3-1 cells by increasing the VCR uptake in the cells. pranlukast 28-36 ATP binding cassette subfamily C member 1 Homo sapiens 75-78 9790952-0 1998 A leukotriene receptor antagonist, ONO-1078, modulates drug sensitivity and leukotriene C4 efflux in lung cancer cells expressing multidrug resistance protein. pranlukast 35-43 ATP binding cassette subfamily C member 1 Homo sapiens 130-158 9790952-1 1998 ONO-1078 is a new class of peptide leukotriene receptor antagonist, and multidrug resistance protein (MRP) is a membrane tranporter of multiple anticancer drugs and endogenous leukotriene C4 (LTC4). pranlukast 0-8 ATP binding cassette subfamily C member 1 Homo sapiens 102-105 9790952-4 1998 The effect of ONO-1078 on MRP-mediated calcein-efflux was determined by flow cytometry. pranlukast 14-22 ATP binding cassette subfamily C member 1 Homo sapiens 26-29 9790952-7 1998 Our findings indicate that ONO-1078 modulates multidrug resistance and inhibits LTC4-efflux in lung cancer cells, by inhibition of MRP function. pranlukast 27-35 ATP binding cassette subfamily C member 1 Homo sapiens 131-134