PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11595704-12	2001	Multidrug resistance-reversing agents, such as ONO-1078 and MK571, that directly interact and inhibit the transporting activity of MRP1 may be useful for treating ATL patients.	pranlukast	47-55	ATP binding cassette subfamily C member 1	Homo sapiens	131-135	
9751271-2	1998	We examined the effect of ONO-1078 on the sensitivity to vincristine (VCR) of MRP overexpressing multidrug-resistant CV60 and its parental drug-sensitive KB-3-1 cell lines.	pranlukast	26-34	ATP binding cassette subfamily C member 1	Homo sapiens	78-81	
9751271-8	1998	These findings suggest that ONO-1078 inhibits the transporting activity of MRP and that ONO-1078 increases the sensitivity to VCR of KB-3-1 cells by increasing the VCR uptake in the cells.	pranlukast	28-36	ATP binding cassette subfamily C member 1	Homo sapiens	75-78	
9790952-0	1998	A leukotriene receptor antagonist, ONO-1078, modulates drug sensitivity and leukotriene C4 efflux in lung cancer cells expressing multidrug resistance protein.	pranlukast	35-43	ATP binding cassette subfamily C member 1	Homo sapiens	130-158	
9790952-1	1998	ONO-1078 is a new class of peptide leukotriene receptor antagonist, and multidrug resistance protein (MRP) is a membrane tranporter of multiple anticancer drugs and endogenous leukotriene C4 (LTC4).	pranlukast	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	102-105	
9790952-4	1998	The effect of ONO-1078 on MRP-mediated calcein-efflux was determined by flow cytometry.	pranlukast	14-22	ATP binding cassette subfamily C member 1	Homo sapiens	26-29	
9790952-7	1998	Our findings indicate that ONO-1078 modulates multidrug resistance and inhibits LTC4-efflux in lung cancer cells, by inhibition of MRP function.	pranlukast	27-35	ATP binding cassette subfamily C member 1	Homo sapiens	131-134