PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10854050-4	2000	Here we demonstrate biochemically that cdc2/cyclin B1 accumulates at the centrosome in late G2 as the inactive, phosphotyrosine 15 form and that the centrosomal cdc2/cyclin B1 can be activated in vitro by recombinant cdc25B.	Phosphotyrosine	112-127	cyclin dependent kinase 1	Homo sapiens	39-43	
8250970-4	1993	L86-8275 inhibited [32P]orthophosphate labeling of p34cdc2 threonine and tyrosine residues and decreased the phosphotyrosine content of p34cdc2.	Phosphotyrosine	109-124	cyclin dependent kinase 1	Homo sapiens	136-143	
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Phosphotyrosine	83-98	cyclin dependent kinase 1	Homo sapiens	9-16	
14731678-1	1994	The phosphotyrosine content of the cdc2 protein kinases, the catalytic component of maturation-promoting factor (MPF), is an important parameter of mitotic regulation in a variety of organisms.	Phosphotyrosine	4-19	cyclin dependent kinase 1	Homo sapiens	35-39	
9683525-8	1998	In cells treated with TPA, most p34(cdc2) was found in the slowly migrating forms on Western blots, which contained increased levels of phosphotyrosine.	Phosphotyrosine	136-151	cyclin dependent kinase 1	Homo sapiens	36-40	
9552383-2	1996	Here cytokinin stimulates removal of phosphotyrosine from p34cdc2 kinase and concurrently capacity for activation of the kinase by Cdc25 phosphatase declines while activity of the kinase increases and cells enter mitosis.	Phosphotyrosine	37-52	cyclin dependent kinase 1	Homo sapiens	58-65	
7823958-6	1995	This activation-dependent induction of H1 kinase activity in T cells is associated with a decrease in the phosphotyrosine content of p34cdc2.	Phosphotyrosine	106-121	cyclin dependent kinase 1	Homo sapiens	133-140	
8250970-5	1993	Diminution of p34cdc2 phosphotyrosine appeared selective, as a general depletion of cellular phosphotyrosine was not observed.	Phosphotyrosine	22-37	cyclin dependent kinase 1	Homo sapiens	14-21	
8406990-13	1993	In vitro dephosphorylation of phosphotyrosine of p34cdc2 protein kinase was observed after exposure to okadaic acid in a concentration-dependent manner.	Phosphotyrosine	30-45	cyclin dependent kinase 1	Homo sapiens	49-56	
1664235-2	1991	Recent studies have shown that p34cdc2 is also a major tyrosine-phosphorylated protein in HeLa cells and that its phosphotyrosine content is cell cycle regulated and related to its kinase activity.	Phosphotyrosine	114-129	cyclin dependent kinase 1	Homo sapiens	31-38	
1936263-4	1991	Its ability to phosphorylate casein but not histone, and its phosphorylation on tyrosine, detected by anti-phosphotyrosine antibodies, indicates the form of p34cdc2 purified is the inactive or apoenzyme form.	Phosphotyrosine	107-122	cyclin dependent kinase 1	Homo sapiens	157-164	
35392228-6	2022	In the present course of investigation, PKM2 modulation did not influence Cdk7 activity, but phosphotyrosine binding forms of PKM2 co-immunoprecipitated with pY15-containing Cdk1-cyclinB and enhanced formation of active pT161 Cdk1-cyclin B complexes.	Phosphotyrosine	93-108	cyclin dependent kinase 1	Homo sapiens	226-230	
2462672-2	1988	In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation.	Phosphotyrosine	53-68	cyclin dependent kinase 1	Homo sapiens	15-19