PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29624602-6 2018 Collectively, our results demonstrate a unique behavioral phenotype in the rTg4510 mouse model of tauopathy that strongly correlates with disease progression, and that early interventions which reduce tau pathology ameliorate the progression of the locomotor dysfunction. rtg4510 75-82 microtubule associated protein tau Homo sapiens 98-101 34039738-7 2021 The clearance of tau from postsynaptic compartments correlated with attenuated tauopathy and improved cognitive performance of rTg4510 transgenic mice on two behavioral tests. rtg4510 127-134 microtubule associated protein tau Homo sapiens 17-20 33990839-7 2021 Using immunofluorescence staining on brain tissue from young (2.5-month-old) and aged (8.5- to 10-month-old) rTg4510 mice, we found a tau- and age-dependent increase in cytoplasmic mislocalization of Rpb1. rtg4510 109-116 microtubule associated protein tau Homo sapiens 134-137 29733334-6 2018 By suppressing human tau expression for 6 months in the APP/PS1 x rTg4510 mice using doxycycline, AT8 tau pathology, bioactivity, and astrogliosis were reduced, though importantly to a lesser extent than lowering tau in the rTg4510 alone mice. rtg4510 66-73 microtubule associated protein tau Homo sapiens 21-24 29733334-6 2018 By suppressing human tau expression for 6 months in the APP/PS1 x rTg4510 mice using doxycycline, AT8 tau pathology, bioactivity, and astrogliosis were reduced, though importantly to a lesser extent than lowering tau in the rTg4510 alone mice. rtg4510 66-73 microtubule associated protein tau Homo sapiens 102-105 29733334-6 2018 By suppressing human tau expression for 6 months in the APP/PS1 x rTg4510 mice using doxycycline, AT8 tau pathology, bioactivity, and astrogliosis were reduced, though importantly to a lesser extent than lowering tau in the rTg4510 alone mice. rtg4510 66-73 microtubule associated protein tau Homo sapiens 102-105 29419480-9 2018 Conclusion: The present findings support the distinct utilities of 11C-PBB3 PET and MRI in rTg4510 and PS19 mice for quantitatively pursuing mechanisms connecting PET-detectable and PET-undetectable tau aggregations to neuronal death, which recapitulate 2 different modes of tau-provoked neurotoxicity. rtg4510 91-98 microtubule associated protein tau Homo sapiens 199-202 34095439-0 2021 Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice. rtg4510 91-98 microtubule associated protein tau Homo sapiens 14-17 32925070-0 2020 S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau. rtg4510 55-62 microtubule associated protein tau Homo sapiens 142-145 32925070-2 2020 rTg4510 mice express mutant human P301L tau and are a model of tau hyperphosphorylation. rtg4510 0-7 microtubule associated protein tau Homo sapiens 40-43 32925070-2 2020 rTg4510 mice express mutant human P301L tau and are a model of tau hyperphosphorylation. rtg4510 0-7 microtubule associated protein tau Homo sapiens 63-66 31171783-3 2019 This suggests that it is not overexpression of mutant human tau alone that contributes to the phenotype in rTg4510 mice. rtg4510 107-114 microtubule associated protein tau Homo sapiens 60-63 31171783-4 2019 Furthermore we show that the tauopathy-like phenotype seen in rTg4510 requires a ~70-copy tau-transgene insertion in a 244 kb deletion in Fgf14, a ~7-copy tTA-transgene insertion in a 508 kb deletion that disrupts another five genes, in addition to high transgene overexpression. rtg4510 62-69 microtubule associated protein tau Homo sapiens 29-32 30107539-4 2018 In the present report, we describe the detection of p-alphaSyn aggregates in the brain of rTg4510 mice that overexpress human P301L mutant tau. rtg4510 90-97 microtubule associated protein tau Homo sapiens 139-142 29624602-0 2018 Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy. rtg4510 71-78 microtubule associated protein tau Homo sapiens 22-25 29624602-3 2018 To further clarify the relationship between these endpoints, we treated the rTg4510 mice with either doxycycline to reduce mutant tau expression or an O-GlcNAcase inhibitor Thiamet G, which has been shown to ameliorate tau pathology in animal models. rtg4510 76-83 microtubule associated protein tau Homo sapiens 130-133 29624602-7 2018 These findings suggest that better understanding the relationship between locomotor deficits and tau pathology in the rTg4510 model may improve our understanding of the mechanisms underlying behavioral disturbances in patients with tauopathies. rtg4510 118-125 microtubule associated protein tau Homo sapiens 97-100 28500862-7 2017 The resulting APP/PS1-rTg4510 mice had a threefold increase in tau seeding activity over the rTg4510 strain, without change in tau production or extracellular release. rtg4510 22-29 microtubule associated protein tau Homo sapiens 63-66 25881209-0 2015 Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. rtg4510 52-59 microtubule associated protein tau Homo sapiens 77-80 28411086-4 2017 We established that hTau expression during the first 6 postnatal weeks was important for the progression of tauopathy in rTg4510 mice. rtg4510 121-128 microtubule associated protein tau Homo sapiens 20-24 28411086-8 2017 We present two consequences of hTau expression in CA1 in rTg4510 mice: an early decrease in neuron number already established prior to the presence of hyperphosphorylated tau species and a later neurodegeneration dependent on hyperphosphorylated tau. rtg4510 57-64 microtubule associated protein tau Homo sapiens 31-35 28411086-11 2017 Our results in rTg4510 mice argue that it is promising to lower hyperphosphorylated tau species at early stages of tau pathology to protect from neurodegeneration. rtg4510 15-22 microtubule associated protein tau Homo sapiens 84-87 28411086-11 2017 Our results in rTg4510 mice argue that it is promising to lower hyperphosphorylated tau species at early stages of tau pathology to protect from neurodegeneration. rtg4510 15-22 microtubule associated protein tau Homo sapiens 115-118 26519432-3 2016 We explored the behavioral phenotype of a mouse model (rTg4510) carrying the human tau P301L mutation found in a familial form of FTD. rtg4510 55-62 microtubule associated protein tau Homo sapiens 83-86 26519432-5 2016 In addition to cognitive impairments, rTg4510 mice exhibited a hyperactivity phenotype which correlated with progression of tau pathology and was dependent on P301L tau transgene expression. rtg4510 38-45 microtubule associated protein tau Homo sapiens 124-127 26519432-5 2016 In addition to cognitive impairments, rTg4510 mice exhibited a hyperactivity phenotype which correlated with progression of tau pathology and was dependent on P301L tau transgene expression. rtg4510 38-45 microtubule associated protein tau Homo sapiens 165-168 25881209-0 2015 Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology. rtg4510 52-59 microtubule associated protein tau Homo sapiens 12-15 25881209-10 2015 Female rTg4510 mice displayed significantly more aggressive accumulation of pathological tau in the brain and elevation of total tau in CSF than their male littermates. rtg4510 7-14 microtubule associated protein tau Homo sapiens 89-92 25881209-10 2015 Female rTg4510 mice displayed significantly more aggressive accumulation of pathological tau in the brain and elevation of total tau in CSF than their male littermates. rtg4510 7-14 microtubule associated protein tau Homo sapiens 129-132 25881209-12 2015 The data indicate that development of tauopathy in rTg4510 mice involves the accumulation of a pool of pathological tau that carries multiple post-translational modifications, a process that can be detected well before the histological detection of NFTs. rtg4510 51-58 microtubule associated protein tau Homo sapiens 38-41 24428919-12 2014 CONCLUSIONS: Overall, our data shows that introduction of the C57BL/6 strain into the rTg4510 mouse background modestly alters the tau pathology that was originally reported in rTg4510 on the F1 FVB/129 background. rtg4510 86-93 microtubule associated protein tau Homo sapiens 131-134 24411290-7 2014 At the age of 4 months, rTg4510 mice show axonal tau inclusions and unmyelinated processes. rtg4510 24-31 microtubule associated protein tau Homo sapiens 49-52 25515210-0 2015 Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer"s disease. rtg4510 61-68 microtubule associated protein tau Homo sapiens 46-49 24428919-12 2014 CONCLUSIONS: Overall, our data shows that introduction of the C57BL/6 strain into the rTg4510 mouse background modestly alters the tau pathology that was originally reported in rTg4510 on the F1 FVB/129 background. rtg4510 177-184 microtubule associated protein tau Homo sapiens 131-134 24278327-0 2013 Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. rtg4510 70-77 microtubule associated protein tau Homo sapiens 0-3 24028867-0 2014 Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau. rtg4510 49-56 microtubule associated protein tau Homo sapiens 11-14 24028867-0 2014 Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau. rtg4510 49-56 microtubule associated protein tau Homo sapiens 85-88 24595194-3 2014 Our histological analyses with tau antibodies and fluorescent tau ligands on rTg4510 mice revealed that tau oligomer formation was distinct from tangle formation. rtg4510 77-84 microtubule associated protein tau Homo sapiens 62-65 24595194-3 2014 Our histological analyses with tau antibodies and fluorescent tau ligands on rTg4510 mice revealed that tau oligomer formation was distinct from tangle formation. rtg4510 77-84 microtubule associated protein tau Homo sapiens 62-65 21854751-5 2011 Mitochondrial distribution is progressively disrupted with age in rTg4510 brain, particularly in somata and neurites containing Alz50-positive tau aggregates. rtg4510 66-73 microtubule associated protein tau Homo sapiens 143-146 21854751-9 2011 Because abnormalities reverted to normal if soluble tau was suppressed in rTg4510 mice, even in the continued presence of fibrillar tau inclusions, we suggest that soluble tau plays an important role in mitochondrial abnormalities, which likely contribute to neuronal dysfunction in AD. rtg4510 74-81 microtubule associated protein tau Homo sapiens 52-55 21152933-1 2011 rTg4510 transgenic (TG) mice overexpress mutant (P301L) human tau protein. rtg4510 0-7 microtubule associated protein tau Homo sapiens 62-65