PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17234777-3 2007 We have elucidated the role of constitutive EGFR signaling in malignant progression by stably transfecting colon cancer cells with a human transforming growth factor-alpha cDNA (a ligand for EGFR) under repressible control by tetracycline. Tetracycline 226-238 tumor necrosis factor Homo sapiens 139-171 31266502-3 2019 Recently, we demonstrated that minocycline, a tetracycline antibiotic, successfully inhibited the TNF-alpha-induced fusion of MDA-MB-435 cancer cells with M13SV1 breast epithelial cells. Tetracycline 46-58 tumor necrosis factor Homo sapiens 98-107 29636110-11 2018 Likewise, the tetracycline-based antibiotic minocycline, which exhibits anti-inflammatory properties, was also effective in both inhibiting the TNF-alpha-induced MMP9 expression in M13SV1-Cre cells and blocking the TNF-alpha-induced fusion frequency of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells. Tetracycline 14-26 tumor necrosis factor Homo sapiens 144-153 29636110-11 2018 Likewise, the tetracycline-based antibiotic minocycline, which exhibits anti-inflammatory properties, was also effective in both inhibiting the TNF-alpha-induced MMP9 expression in M13SV1-Cre cells and blocking the TNF-alpha-induced fusion frequency of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells. Tetracycline 14-26 tumor necrosis factor Homo sapiens 215-224 24824125-1 2014 OBJECTIVE: To study the role of tumor necrosis factor-alpha (TNFalpha) in the anti-replication effects of tetracycline (Tet) on hepatitis B virus (HBV). Tetracycline 106-118 tumor necrosis factor Homo sapiens 61-69 21461372-3 2011 In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Tetracycline 65-77 tumor necrosis factor Homo sapiens 123-126 11390446-2 2001 In a transgenic model (rat insulin promoter-lymphocytic choriomeningitis virus) of virally induced diabetes, TNF-alpha enhanced disease incidence when induced through an islet-specific tetracycline-dependent promoter system early during pathogenesis. Tetracycline 185-197 tumor necrosis factor Homo sapiens 109-118 16220550-6 2006 In the present study, we report that tetracycline and minocycline dose-dependently reduce TNF-alpha and IL-6 release by adult human microglia upon stimulation with a combination of Abeta, SAP, and C1q. Tetracycline 37-49 tumor necrosis factor Homo sapiens 90-99 16153435-6 2005 METHODS: A tetracycline-responsive adenoviral vector was used to transfect the TNF-alpha gene (Ad-TNF-alpha) into human esophageal cancer cell lines Bic1, Seg1 and TT, as well as in transformed PKR(+/+) and PKR(-/-) early-passage mouse embryo fibroblasts. Tetracycline 11-23 tumor necrosis factor Homo sapiens 79-88 12519399-10 2003 The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups. Tetracycline 23-49 tumor necrosis factor Homo sapiens 194-203 12519399-10 2003 The positive result of tetracycline hydrochloride treatment was accompanied by certain particularities in the dynamics of studied cytokines and receptors: the concentrations of IL-6, IL-1 beta, TNF-alpha dropped quicker and reached lower levels, and the concentrations of sIL-6R, IL-1RA, sTNFR1 increased faster and reached higher maximum levels in the tetracycline-treated groups. Tetracycline 23-35 tumor necrosis factor Homo sapiens 194-203 10415044-6 1999 TNF-alpha also inhibits CIITA mRNA accumulation and protein expression in a tetracycline-regulated system without affecting promoter activity. Tetracycline 76-88 tumor necrosis factor Homo sapiens 0-9 8832479-9 1996 Pretreatment of diseased cementum with tetracycline (50 mg/ml) was found to block the secretion of TNF alpha from cementum-stimulated monocytes. Tetracycline 39-51 tumor necrosis factor Homo sapiens 99-108 9813060-3 1998 Transforming growth factor alpha (TGF-alpha) was ectopically expressed by stable transfection of a TGF-alpha cDNA under repressible tetracycline control. Tetracycline 132-144 tumor necrosis factor Homo sapiens 0-32 9269991-0 1997 Development of an adenovirus vector with tetracycline-regulatable human tumor necrosis factor alpha gene expression. Tetracycline 41-53 tumor necrosis factor Homo sapiens 72-99 9269991-3 1997 We have recently modified a tetracycline (Tc) repressor/operator-based mammalian gene expression system and have generated a Tc-responsive recombinant adenovirus vector, AdVtTA.TNF-alpha. Tetracycline 28-40 tumor necrosis factor Homo sapiens 177-186 9269991-3 1997 We have recently modified a tetracycline (Tc) repressor/operator-based mammalian gene expression system and have generated a Tc-responsive recombinant adenovirus vector, AdVtTA.TNF-alpha. Tetracycline 42-44 tumor necrosis factor Homo sapiens 177-186 9269991-3 1997 We have recently modified a tetracycline (Tc) repressor/operator-based mammalian gene expression system and have generated a Tc-responsive recombinant adenovirus vector, AdVtTA.TNF-alpha. Tetracycline 125-127 tumor necrosis factor Homo sapiens 177-186 9269991-4 1997 A variety of human tumor cells and T lymphocytes transduced by AdVtTA.TNF-alpha secreted high-titer (5,000-100,000 pg/10(6) cells/24 h) and biologically active TNF-alpha in the absence of Tc. Tetracycline 188-190 tumor necrosis factor Homo sapiens 70-79 9269991-5 1997 Expression of TNF-alpha in the transduced cells was nondetectable when the culture medium contained as little as 0.1 microg/ml of Tc. Tetracycline 130-132 tumor necrosis factor Homo sapiens 14-23 9085232-2 1997 Based on tetracycline (TTC) ability to bind divalent metal ions, the present study was designed to examine the effect of TTC on P. gingivalis LPS-induced lesions in vivo and on LPS-induced TNF alpha production in vitro. Tetracycline 9-21 tumor necrosis factor Homo sapiens 189-198 9407973-1 1997 In the present investigation, we have transfected a human malignant glioma cell line, U-1242 MG, and derived clones that produce transforming growth factor alpha (TGF-alpha) in an inducible manner using the tetracycline suppressible vector system. Tetracycline 207-219 tumor necrosis factor Homo sapiens 129-161 8832479-11 1996 The direct addition of tetracycline to cementum-stimulated monocyte culture was found to block TNF alpha secretion in a dose dependent manner. Tetracycline 23-35 tumor necrosis factor Homo sapiens 95-104 8832479-14 1996 In addition, tetracycline was found to be a potent inhibitor of TNF alpha secretion by cementum-stimulated monocytes, suggesting a novel mechanism for this drug in periodontal therapy. Tetracycline 13-25 tumor necrosis factor Homo sapiens 64-73 8641787-7 1996 Furthermore, tetracycline was found to inhibit LPS-induced TNF-alpha and IL-1 beta secretion, but not cytokine mRNA accumulation, in human monocytes in vitro. Tetracycline 13-25 tumor necrosis factor Homo sapiens 59-68 8503562-0 1993 Changes in cell population and tumor necrosis factor, interleukin-6, and interleukin-8 in malignant pleural effusions after treatment with intrapleural tetracycline. Tetracycline 152-164 tumor necrosis factor Homo sapiens 31-52 8503562-7 1993 IL-6, IL-8, and TNF were markedly increased on Day 4 after TC intrapleural injection and then decreased to baseline levels on Day 14. Tetracycline 59-61 tumor necrosis factor Homo sapiens 16-19