PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26777664-6	2016	This issue was investigated here using intrastriatal injections of a tetracycline-inducible adeno-associated viral vector expressing human GDNF cDNA (AAV-tetON-GDNF) in rats, and doxycycline (DOX; 0.01, 0.03, 0.5 and 3mg/ml) in the drinking water during 5weeks.	Tetracycline	69-81	glial cell derived neurotrophic factor	Homo sapiens	139-143	
26777664-6	2016	This issue was investigated here using intrastriatal injections of a tetracycline-inducible adeno-associated viral vector expressing human GDNF cDNA (AAV-tetON-GDNF) in rats, and doxycycline (DOX; 0.01, 0.03, 0.5 and 3mg/ml) in the drinking water during 5weeks.	Tetracycline	69-81	glial cell derived neurotrophic factor	Homo sapiens	160-164	
23269553-4	2013	A modified tetracycline operator 7 (tetO7) was inserted into a region upstream of the EF1-alpha promoter to drive GDNF expression.	Tetracycline	11-23	glial cell derived neurotrophic factor	Homo sapiens	114-118	
26466815-5	2015	Briefly, SCs were transduced with a tetracycline-inducible (Tet-On) GDNF overexpressing lentivirus before transplantation.	Tetracycline	36-48	glial cell derived neurotrophic factor	Homo sapiens	68-72	
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	Tetracycline	23-35	glial cell derived neurotrophic factor	Homo sapiens	78-82	
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	Tetracycline	23-35	glial cell derived neurotrophic factor	Homo sapiens	84-89	
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	Tetracycline	23-35	glial cell derived neurotrophic factor	Homo sapiens	119-124	
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	Tetracycline	37-40	glial cell derived neurotrophic factor	Homo sapiens	78-82	
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	Tetracycline	37-40	glial cell derived neurotrophic factor	Homo sapiens	84-89	
24997241-3	2014	We previously improved tetracycline (Tet)-On lentivirus system carrying human GDNF (hGDNF) gene, and demonstrated that hGDNF gene expression was tightly regulated and functional in vitro.	Tetracycline	37-40	glial cell derived neurotrophic factor	Homo sapiens	119-124	
24997241-4	2014	Here we further examined the efficiency and neuroprotection of Tet-On lentivirus-mediated hGDNF gene regulation in neural progenitor cells (NPCs) and a rat model of parkinsonism.	Tetracycline	63-66	glial cell derived neurotrophic factor	Homo sapiens	90-95	
24997241-7	2014	Intrastriatal injections of Tet-On lentivirus vectors resulted in dramatically increased levels of hGDNF protein in the striatum of rats with Dox-drinking water, when compared to lentivirus-injected and saline-injected rats with normal drinking water, respectively.	Tetracycline	28-31	glial cell derived neurotrophic factor	Homo sapiens	99-104	
24997241-9	2014	To the best of our knowledge, this is the first report that hGDNF gene transfer by Tet-On lentivirus vectors is tightly regulated in rat brain, and Dox-induced hGDNF is functional in neuroprotection of nigral DA neurons in a rat model of parkinsonism.	Tetracycline	83-86	glial cell derived neurotrophic factor	Homo sapiens	60-65	
24728940-5	2014	To design this system for regulation of GDNF expression, we transduced two lentiviral vectors, one containing a constitutively active GDNF transgene flanked by two loxP sites, and the other containing a tetracycline-inducible cre transgene along with its constitutively active transactivator, into Schwann cells (SCs).	Tetracycline	203-215	glial cell derived neurotrophic factor	Homo sapiens	40-44	
19639608-4	2009	METHODS: A tetracycline-inducible adeno-associated virus (AAV)-1 vector expressing human GDNF cDNA was administered unilaterally in the rat striatum 5 weeks after 6-hydroxydopamine.	Tetracycline	11-23	glial cell derived neurotrophic factor	Homo sapiens	89-93	
9299553-4	1997	Therefore we adopted a self-contained tetracycline-regulated expression system to acquire an rAdv expressing hGDNF.	Tetracycline	38-50	glial cell derived neurotrophic factor	Homo sapiens	109-114	
17223106-1	2007	An autoregulated tetracycline-inducible recombinant adeno-associated viral vector (rAAV-pTet(bidi)ON) utilizing the rtTAM2 reverse tetracycline transactivator (rAAV-rtTAM2) was used to conditionally express the human GDNF cDNA.	Tetracycline	17-29	glial cell derived neurotrophic factor	Homo sapiens	217-221	
17223106-2	2007	Doxycycline, a tetracycline analog, induced a time- and dose-dependent release of GDNF in vitro in human glioma cells infected with rAAV-rtTAM2 serotype 2 virus.	Tetracycline	15-27	glial cell derived neurotrophic factor	Homo sapiens	82-86