PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34440932-3 2021 COL-3"s inhibitory effects on TNF-alpha were reproduced by the tetracycline antibiotic doxycycline (DOX; 50 microM), the glucocorticoid dexamethasone, and apocynin (APO), an inhibitor of the superoxide-producing enzyme NADPH oxidase. Tetracycline 63-75 tumor necrosis factor Mus musculus 30-39 23469077-3 2013 In the present study we found that administration of chemically modified tetracycline-3 (COL-3), inhibits lipopolysaccharide (LPS)-induced microglial and p38 MAPK activation, as well as the increase in TNF-alpha, but not IL-1beta expression, in the brains of BALB/c mice. Tetracycline 73-85 tumor necrosis factor Mus musculus 202-211 3266953-0 1988 Tumor necrosis factor alpha and interleukin-1 stimulate bone resorption in vivo as measured by urinary [3H]tetracycline excretion from prelabeled mice. Tetracycline 107-119 tumor necrosis factor Mus musculus 0-27 27270547-11 2016 Furthermore, expressions of inflammatory cytokines IL-4, IL-13, and TNF-alpha in skin lesions were down-regulated in 2% TET group compared with AD group (P = 0.035, 0.008, and 0.044, respectively). Tetracycline 120-123 tumor necrosis factor Mus musculus 68-77 31882466-7 2020 In RAW264.7 cells stimulated with LPS, Cox2 and Tnfalpha mRNA were over-expressed in the presence of TC. Tetracycline 101-103 tumor necrosis factor Mus musculus 48-56 31882466-10 2020 Upon application of VLI, only TC down-regulated the expression of LPS-stimulated Cox2 and Tnfalpha mRNA. Tetracycline 30-32 tumor necrosis factor Mus musculus 90-98 31882466-12 2020 CONCLUSION: TC is a chain-breaking antioxidant with a large kinh Upon activation by VLI, TC may undergo degradation and its degradation products affect pleiotropic mediators such as Cox2, Tnfalpha and Ho-1. Tetracycline 12-14 tumor necrosis factor Mus musculus 188-196 12509133-6 2002 Here, we review experiences that were made from using a tetracycline-inducible promotor system (tTA-system) to express TNFalpha at various times during an ongoing autoimmune process, such as the destruction of pancreatic beta-cells in a mouse model for human type 1 diabetes. Tetracycline 56-68 tumor necrosis factor Mus musculus 119-127 23027468-11 2012 Tetracycline had minimum effect on the expression of MMP-9 and tumor necrosis factor-alpha (TNF-alpha) but it decreased gene activation and inhibited the expression of RANK and RANKL, thereby inhibiting Ti-particle-induced inflammatory osteolysis. Tetracycline 0-12 tumor necrosis factor Mus musculus 63-90 23027468-11 2012 Tetracycline had minimum effect on the expression of MMP-9 and tumor necrosis factor-alpha (TNF-alpha) but it decreased gene activation and inhibited the expression of RANK and RANKL, thereby inhibiting Ti-particle-induced inflammatory osteolysis. Tetracycline 0-12 tumor necrosis factor Mus musculus 92-101 15088876-9 2004 Conditioning of diseased cementum with tetracycline before extraction resulted in augmented levels of TNF-alpha and IFN-gamma, and reduced levels of IL-10, compared with untreated diseased cementum. Tetracycline 39-51 tumor necrosis factor Mus musculus 102-111 16153435-6 2005 METHODS: A tetracycline-responsive adenoviral vector was used to transfect the TNF-alpha gene (Ad-TNF-alpha) into human esophageal cancer cell lines Bic1, Seg1 and TT, as well as in transformed PKR(+/+) and PKR(-/-) early-passage mouse embryo fibroblasts. Tetracycline 11-23 tumor necrosis factor Mus musculus 98-107 16153435-12 2005 Inhibition of TNF-alpha expression by tetracycline resulted in downregulation of PKR and decreased apoptosis. Tetracycline 38-50 tumor necrosis factor Mus musculus 14-23 8641787-6 1996 This protection correlates with tetracycline"s ability to reduce LPS-induced TNF-alpha levels in serum. Tetracycline 32-44 tumor necrosis factor Mus musculus 77-86 11033356-4 2000 An adenosine/uridine-rich element from the TNFalpha 3" untranslated region conferred p38-sensitive decay in a tetracycline-regulated mRNA stability assay. Tetracycline 110-122 tumor necrosis factor Mus musculus 43-51 10666115-5 2000 Using the tetracycline-regulated expression system, we show here that conditional overexpression of HO-1 prevents tumor necrosis factor-alpha-induced apoptosis in murine L929 fibroblasts. Tetracycline 10-22 tumor necrosis factor Mus musculus 114-141 10843379-2 2000 By adapting the tetracycline-regulated gene transcription system, we generated a murine model where islet-specific expression of TNFalpha could be repressed/derepressed within 48 hr following introduction/removal of tetracycline in the drinking water. Tetracycline 16-28 tumor necrosis factor Mus musculus 129-137 10843379-2 2000 By adapting the tetracycline-regulated gene transcription system, we generated a murine model where islet-specific expression of TNFalpha could be repressed/derepressed within 48 hr following introduction/removal of tetracycline in the drinking water. Tetracycline 216-228 tumor necrosis factor Mus musculus 129-137