PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34440932-3	2021	COL-3"s inhibitory effects on TNF-alpha were reproduced by the tetracycline antibiotic doxycycline (DOX; 50 microM), the glucocorticoid dexamethasone, and apocynin (APO), an inhibitor of the superoxide-producing enzyme NADPH oxidase.	Tetracycline	63-75	tumor necrosis factor	Mus musculus	30-39	
23469077-3	2013	In the present study we found that administration of chemically modified tetracycline-3 (COL-3), inhibits lipopolysaccharide (LPS)-induced microglial and p38 MAPK activation, as well as the increase in TNF-alpha, but not IL-1beta expression, in the brains of BALB/c mice.	Tetracycline	73-85	tumor necrosis factor	Mus musculus	202-211	
3266953-0	1988	Tumor necrosis factor alpha and interleukin-1 stimulate bone resorption in vivo as measured by urinary [3H]tetracycline excretion from prelabeled mice.	Tetracycline	107-119	tumor necrosis factor	Mus musculus	0-27	
27270547-11	2016	Furthermore, expressions of inflammatory cytokines IL-4, IL-13, and TNF-alpha in skin lesions were down-regulated in 2% TET group compared with AD group (P = 0.035, 0.008, and 0.044, respectively).	Tetracycline	120-123	tumor necrosis factor	Mus musculus	68-77	
31882466-7	2020	In RAW264.7 cells stimulated with LPS, Cox2 and Tnfalpha mRNA were over-expressed in the presence of TC.	Tetracycline	101-103	tumor necrosis factor	Mus musculus	48-56	
31882466-10	2020	Upon application of VLI, only TC down-regulated the expression of LPS-stimulated Cox2 and Tnfalpha mRNA.	Tetracycline	30-32	tumor necrosis factor	Mus musculus	90-98	
31882466-12	2020	CONCLUSION: TC is a chain-breaking antioxidant with a large kinh Upon activation by VLI, TC may undergo degradation and its degradation products affect pleiotropic mediators such as Cox2, Tnfalpha and Ho-1.	Tetracycline	12-14	tumor necrosis factor	Mus musculus	188-196	
12509133-6	2002	Here, we review experiences that were made from using a tetracycline-inducible promotor system (tTA-system) to express TNFalpha at various times during an ongoing autoimmune process, such as the destruction of pancreatic beta-cells in a mouse model for human type 1 diabetes.	Tetracycline	56-68	tumor necrosis factor	Mus musculus	119-127	
23027468-11	2012	Tetracycline had minimum effect on the expression of MMP-9 and tumor necrosis factor-alpha (TNF-alpha) but it decreased gene activation and inhibited the expression of RANK and RANKL, thereby inhibiting Ti-particle-induced inflammatory osteolysis.	Tetracycline	0-12	tumor necrosis factor	Mus musculus	63-90	
23027468-11	2012	Tetracycline had minimum effect on the expression of MMP-9 and tumor necrosis factor-alpha (TNF-alpha) but it decreased gene activation and inhibited the expression of RANK and RANKL, thereby inhibiting Ti-particle-induced inflammatory osteolysis.	Tetracycline	0-12	tumor necrosis factor	Mus musculus	92-101	
15088876-9	2004	Conditioning of diseased cementum with tetracycline before extraction resulted in augmented levels of TNF-alpha and IFN-gamma, and reduced levels of IL-10, compared with untreated diseased cementum.	Tetracycline	39-51	tumor necrosis factor	Mus musculus	102-111	
16153435-6	2005	METHODS: A tetracycline-responsive adenoviral vector was used to transfect the TNF-alpha gene (Ad-TNF-alpha) into human esophageal cancer cell lines Bic1, Seg1 and TT, as well as in transformed PKR(+/+) and PKR(-/-) early-passage mouse embryo fibroblasts.	Tetracycline	11-23	tumor necrosis factor	Mus musculus	98-107	
16153435-12	2005	Inhibition of TNF-alpha expression by tetracycline resulted in downregulation of PKR and decreased apoptosis.	Tetracycline	38-50	tumor necrosis factor	Mus musculus	14-23	
8641787-6	1996	This protection correlates with tetracycline"s ability to reduce LPS-induced TNF-alpha levels in serum.	Tetracycline	32-44	tumor necrosis factor	Mus musculus	77-86	
11033356-4	2000	An adenosine/uridine-rich element from the TNFalpha 3" untranslated region conferred p38-sensitive decay in a tetracycline-regulated mRNA stability assay.	Tetracycline	110-122	tumor necrosis factor	Mus musculus	43-51	
10666115-5	2000	Using the tetracycline-regulated expression system, we show here that conditional overexpression of HO-1 prevents tumor necrosis factor-alpha-induced apoptosis in murine L929 fibroblasts.	Tetracycline	10-22	tumor necrosis factor	Mus musculus	114-141	
10843379-2	2000	By adapting the tetracycline-regulated gene transcription system, we generated a murine model where islet-specific expression of TNFalpha could be repressed/derepressed within 48 hr following introduction/removal of tetracycline in the drinking water.	Tetracycline	16-28	tumor necrosis factor	Mus musculus	129-137	
10843379-2	2000	By adapting the tetracycline-regulated gene transcription system, we generated a murine model where islet-specific expression of TNFalpha could be repressed/derepressed within 48 hr following introduction/removal of tetracycline in the drinking water.	Tetracycline	216-228	tumor necrosis factor	Mus musculus	129-137