PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21779459-3 2010 Furthermore, activation of conditional alleles of Myc, either tetracycline or estrogen inducible, upregulates expression of a large number of genes, both in tissue culture and in transgenic animals. Tetracycline 62-74 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-53 21969595-4 2011 Many of the recurring lymphomas (76%) harbored mutations in the tetracycline transactivator, resulting in expression of the MYC transgene even in the presence of doxycycline. Tetracycline 64-76 MYC proto-oncogene, bHLH transcription factor Homo sapiens 124-127 25690653-3 2015 Here, we show that lncRNAs are a main component of the Myc-regulated transcriptional program using the P493-6 tetracycline-repressible myc model. Tetracycline 110-122 MYC proto-oncogene, bHLH transcription factor Homo sapiens 55-58 25690653-3 2015 Here, we show that lncRNAs are a main component of the Myc-regulated transcriptional program using the P493-6 tetracycline-repressible myc model. Tetracycline 110-122 MYC proto-oncogene, bHLH transcription factor Homo sapiens 135-138 23874405-9 2013 Finally, in a cell line with a tetracycline-regulated c-MYC gene, diclofenac decreased proliferation both in the presence and absence of c-MYC. Tetracycline 31-43 MYC proto-oncogene, bHLH transcription factor Homo sapiens 54-59 21378266-6 2011 Tet in the culture medium activated myc transcription and translation, allowing efficient expansion of homogeneous, clonal, karyotypically normal human CNS precursors ex vivo; in vivo, where Tet was absent, myc was not expressed, and self-renewal was entirely inactivated (as was tumorigenic potential). Tetracycline 0-3 MYC proto-oncogene, bHLH transcription factor Homo sapiens 36-39 21378266-6 2011 Tet in the culture medium activated myc transcription and translation, allowing efficient expansion of homogeneous, clonal, karyotypically normal human CNS precursors ex vivo; in vivo, where Tet was absent, myc was not expressed, and self-renewal was entirely inactivated (as was tumorigenic potential). Tetracycline 0-3 MYC proto-oncogene, bHLH transcription factor Homo sapiens 207-210 12565711-7 2003 Transcription of both ODC-CAT and endogenous odc was strongly induced in HeLa cells expressing tetracycline-regulated c-Myc, concomitant with c-Myc promoting the S-phase entry of the cells. Tetracycline 95-107 MYC proto-oncogene, bHLH transcription factor Homo sapiens 118-123 15735022-4 2005 Similar mitotic aberrations were also observed in a panel of BL lines and were suppressed, in parallel with TPP II down-regulation, upon reversion of BL-like characteristics in EBV-immortalized B lymphocytes carrying a tetracycline-regulated c-myc. Tetracycline 219-231 MYC proto-oncogene, bHLH transcription factor Homo sapiens 242-247 15319038-4 2004 Coinfection of Ad vectors containing the siRNA expression system under the control of the Dox-inducible H1 promoter and Ad vectors expressing a tetracycline repressor inhibited the expression levels of p53 and c-Myc in a dose-dependent manner with both Dox and viral dose. Tetracycline 144-156 MYC proto-oncogene, bHLH transcription factor Homo sapiens 210-215 35115371-4 2022 To that end, we performed ChIP-seq, RNA-seq, 4C-seq and SIQHiC (Spike-in Quantitative Hi-C) on the U2OS osteosarcoma cell line with tetracycline-inducible MYC MYC overexpression in U2OS cells modulated histone acetylation and increased MYC binding at superenhancers. Tetracycline 132-144 MYC proto-oncogene, bHLH transcription factor Homo sapiens 155-158 11175856-3 2001 Here we use the tetracycline regulatory system to conditionally express the human c-MYC oncogene in the mammary epithelium of transgenic mice. Tetracycline 16-28 MYC proto-oncogene, bHLH transcription factor Homo sapiens 82-87 9102209-4 1997 Elevated expression of ING1 in P19 and rodent fibroblast cells containing a tetracycline-controlled human c-myc gene enhanced the extent of serum starvation-induced apoptosis. Tetracycline 76-88 MYC proto-oncogene, bHLH transcription factor Homo sapiens 106-111 11434870-5 2001 In an exciting recent finding, D"Cruz et al discovered tetracycline-regulated c-Myc overexpression in the mammary gland induced invasive mammary tumors that regressed upon withdrawal of c-Myc expression. Tetracycline 55-67 MYC proto-oncogene, bHLH transcription factor Homo sapiens 78-83 11434870-5 2001 In an exciting recent finding, D"Cruz et al discovered tetracycline-regulated c-Myc overexpression in the mammary gland induced invasive mammary tumors that regressed upon withdrawal of c-Myc expression. Tetracycline 55-67 MYC proto-oncogene, bHLH transcription factor Homo sapiens 186-191 10956386-4 2000 As a model for myc activation in BL cells, we have established a human EBV-EBNA1 positive B-cell line, P493-6, in which myc is expressed under the control of a tetracycline regulated promoter. Tetracycline 160-172 MYC proto-oncogene, bHLH transcription factor Homo sapiens 15-18 10956386-4 2000 As a model for myc activation in BL cells, we have established a human EBV-EBNA1 positive B-cell line, P493-6, in which myc is expressed under the control of a tetracycline regulated promoter. Tetracycline 160-172 MYC proto-oncogene, bHLH transcription factor Homo sapiens 120-123 10544182-7 1999 On the contrary, tetracycline-induced transgenic c-myc sensitized stably transfected CCRF-CEM derivatives to butyrate-induced cell death. Tetracycline 17-29 MYC proto-oncogene, bHLH transcription factor Homo sapiens 49-54 10467407-5 1999 To address this controversy, we stably transfected the GC-sensitive human T-ALL cell line CEM-C7H2 with constructs allowing tetracycline-regulated expression of c-Myc. Tetracycline 124-136 MYC proto-oncogene, bHLH transcription factor Homo sapiens 161-166 9794226-3 1998 To address these issues, we have generated rodent fibroblast cell lines that harbor a human c-myc gene under the control of a tetracycline-regulated promoter. Tetracycline 126-138 MYC proto-oncogene, bHLH transcription factor Homo sapiens 92-97 35115371-4 2022 To that end, we performed ChIP-seq, RNA-seq, 4C-seq and SIQHiC (Spike-in Quantitative Hi-C) on the U2OS osteosarcoma cell line with tetracycline-inducible MYC MYC overexpression in U2OS cells modulated histone acetylation and increased MYC binding at superenhancers. Tetracycline 132-144 MYC proto-oncogene, bHLH transcription factor Homo sapiens 159-162 35115371-4 2022 To that end, we performed ChIP-seq, RNA-seq, 4C-seq and SIQHiC (Spike-in Quantitative Hi-C) on the U2OS osteosarcoma cell line with tetracycline-inducible MYC MYC overexpression in U2OS cells modulated histone acetylation and increased MYC binding at superenhancers. Tetracycline 132-144 MYC proto-oncogene, bHLH transcription factor Homo sapiens 236-239 29100357-4 2017 By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation. Tetracycline 15-27 MYC proto-oncogene, bHLH transcription factor Homo sapiens 38-41 29100357-4 2017 By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation. Tetracycline 15-27 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-94 29386360-5 2018 In line with these findings, tigecycline and two related antibiotics, tetracycline and doxycycline, synergized with venetoclax in killing human MYC/BCL2 DHL cells. Tetracycline 70-82 MYC proto-oncogene, bHLH transcription factor Homo sapiens 144-147 29100357-4 2017 By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation. Tetracycline 15-27 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-94 29100357-4 2017 By utilizing a tetracycline-regulated MYC transgene in a mouse T-ALL (EmuSRalpha-tTA;tet-o-MYC) and human Burkitt"s lymphoma (P493-6) model, we demonstrated that DNMT1 and DNMT3B expression depend on high MYC levels, and that their transcription decreased upon MYC-inactivation. Tetracycline 15-27 MYC proto-oncogene, bHLH transcription factor Homo sapiens 91-94