PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20428186-3	2010	TET-induced expression of AREG shRNA markedly reduced autocrine extracellular signal-regulated kinase phosphorylation, strongly inhibited autocrine KC growth with an efficiency similar to metalloproteinase and EGFR inhibitors, and induced several markers of KC differentiation, including keratins 1 and 10.	Tetracycline	0-3	epidermal growth factor receptor	Homo sapiens	210-214	
28003335-3	2017	Moreover, a better response to EGFR-TKI was associated with low RHOB levels in a panel of lung tumor cell lines and in a lung-specific tetracycline-inducible EGFRL858R transgenic mouse model.	Tetracycline	135-147	epidermal growth factor receptor	Homo sapiens	31-35	
20820817-1	2011	PURPOSE: Previous studies suggest tetracycline and other antibiotics lessen the severity of epidermal growth factor receptor (EGFR) inhibitor-induced rash.	Tetracycline	34-46	epidermal growth factor receptor	Homo sapiens	92-124	
20820817-1	2011	PURPOSE: Previous studies suggest tetracycline and other antibiotics lessen the severity of epidermal growth factor receptor (EGFR) inhibitor-induced rash.	Tetracycline	34-46	epidermal growth factor receptor	Homo sapiens	126-130	
15177893-4	2004	In this study, induction of LMP1 increased the EGFR in both protein and promoter levels in a dose dependent manner using tetracycline-regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line.	Tetracycline	121-133	epidermal growth factor receptor	Homo sapiens	47-51	
18543329-0	2008	Tetracycline to prevent epidermal growth factor receptor inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB).	Tetracycline	0-12	epidermal growth factor receptor	Homo sapiens	24-56	
17234777-3	2007	We have elucidated the role of constitutive EGFR signaling in malignant progression by stably transfecting colon cancer cells with a human transforming growth factor-alpha cDNA (a ligand for EGFR) under repressible control by tetracycline.	Tetracycline	226-238	epidermal growth factor receptor	Homo sapiens	44-48	
17234777-3	2007	We have elucidated the role of constitutive EGFR signaling in malignant progression by stably transfecting colon cancer cells with a human transforming growth factor-alpha cDNA (a ligand for EGFR) under repressible control by tetracycline.	Tetracycline	226-238	epidermal growth factor receptor	Homo sapiens	191-195	
15115657-4	2004	In this study, induction of LMP1 increased the EGFR in both protein and promoter levels in a dose-dependent manner using tetracycline-regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line.	Tetracycline	121-133	epidermal growth factor receptor	Homo sapiens	47-51	
35352492-12	2022	CONCLUSIONS: The results of this meta-analysis reinforce the fact that oral tetracycline antibiotics are the most efficacious prophylactic option for acneiform eruptions in EGFR inhibitors.	Tetracycline	76-88	epidermal growth factor receptor	Homo sapiens	173-177	
34362003-3	2021	The cutaneous adverse reactions induced by EGFR inhibitors, particularly papulopustular rash, often require long-term antibiotic treatment with tetracycline agents (mostly minocycline and doxycycline).	Tetracycline	144-156	epidermal growth factor receptor	Homo sapiens	43-47	
19877917-9	1995	A tetracycline-sensitive promoter system for the artificial EGF gene allowed us to experimentally vary EGF secretion rates 20- to 200-fold.	Tetracycline	2-14	epidermal growth factor receptor	Homo sapiens	60-63	
19877917-9	1995	A tetracycline-sensitive promoter system for the artificial EGF gene allowed us to experimentally vary EGF secretion rates 20- to 200-fold.	Tetracycline	2-14	epidermal growth factor receptor	Homo sapiens	103-106	
35113224-1	2022	BACKGROUND: Although pre-emptive therapy with oral tetracycline, moisturizer, sunscreen, and topical corticosteroid is useful for preventing acneiform eruption (AfE) due to epidermal growth factor receptor (EGFR) inhibitors, no studies have examined the efficacy of topical corticosteroids themselves, or investigated the optimal potency of corticosteroid for treating facial AfE (FAfE).	Tetracycline	51-63	epidermal growth factor receptor	Homo sapiens	173-205	
35113224-1	2022	BACKGROUND: Although pre-emptive therapy with oral tetracycline, moisturizer, sunscreen, and topical corticosteroid is useful for preventing acneiform eruption (AfE) due to epidermal growth factor receptor (EGFR) inhibitors, no studies have examined the efficacy of topical corticosteroids themselves, or investigated the optimal potency of corticosteroid for treating facial AfE (FAfE).	Tetracycline	51-63	epidermal growth factor receptor	Homo sapiens	207-211	
33096790-6	2020	Methods: Here, we developed mice with tetracycline-inducible lung-specific expression of the full-length genomic DNA of the human epidermal growth factor receptor containing an L858R mutation or both L858R and T790M mutations and evaluated de novo T790M mutation in untreated transgenic mice carrying a single L858R EGFR mutation.	Tetracycline	38-50	epidermal growth factor receptor	Homo sapiens	130-162