PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11331289-5 2001 Human bladder carcinoma cells mutant for p53 and containing a tetracycline-regulated p21 cDNA showed no significant enhancement of repair upon induction of p21 expression. Tetracycline 62-74 cyclin dependent kinase inhibitor 1A Homo sapiens 85-88 15705882-5 2005 In contrast to previous observations based on constitutively overexpressing cell lines, P21 induced by tetracycline-regulated ERBB2 localizes to the nucleus in arrested cells. Tetracycline 103-115 cyclin dependent kinase inhibitor 1A Homo sapiens 88-91 12374798-2 2002 We investigated possible alterations of MUC2 gene expression by p53 and p21(Sdi1/Waf1/Cip1) in a human colon cancer cell line, DLD-1, establishing subclones in which a tetracycline-regulatable promoter controls exogenous p53 and p21 expression. Tetracycline 168-180 cyclin dependent kinase inhibitor 1A Homo sapiens 229-232 15059906-9 2004 Tetracycline treatment of RII transfectants led to the suppression of p21/waf1/cip1and p27/kip expression, thus, directly demonstrating induction of CDK inhibitors by autocrine TGF-beta leading to growth control of ER(+) breast cancer cells. Tetracycline 0-12 cyclin dependent kinase inhibitor 1A Homo sapiens 70-83 12936910-6 2004 To confirm the role of p21 in G(1) arrest, we created H1299 cells with tetracycline-inducible expression of enhanced green fluorescent protein (EGFP), EGFP fused to p21 (EGFp21), or EGFP fused to p27 (EGFp27), a related cell cycle inhibitor. Tetracycline 71-83 cyclin dependent kinase inhibitor 1A Homo sapiens 23-26 12936910-6 2004 To confirm the role of p21 in G(1) arrest, we created H1299 cells with tetracycline-inducible expression of enhanced green fluorescent protein (EGFP), EGFP fused to p21 (EGFp21), or EGFP fused to p27 (EGFp27), a related cell cycle inhibitor. Tetracycline 71-83 cyclin dependent kinase inhibitor 1A Homo sapiens 165-168 12824923-4 2003 p21(WAF1) expression induced by removal of tetracycline from culture media repressed cell proliferation and resulted in altered cell shape, suggesting induction of differentiation. Tetracycline 43-55 cyclin dependent kinase inhibitor 1A Homo sapiens 0-3 12824923-4 2003 p21(WAF1) expression induced by removal of tetracycline from culture media repressed cell proliferation and resulted in altered cell shape, suggesting induction of differentiation. Tetracycline 43-55 cyclin dependent kinase inhibitor 1A Homo sapiens 4-8 11434920-2 2001 We established osteosarcoma cell lines in which a tetracycline-regulatable promoter controls the induction of RB, p53 and p21. Tetracycline 50-62 cyclin dependent kinase inhibitor 1A Homo sapiens 122-125 11373271-5 2001 After tetracycline withdrawal, cell death and multinucleated giant cells were observed with increased hRAD50 expression, and p21(WAF1/CIP1) but not p53 was increased. Tetracycline 6-18 cyclin dependent kinase inhibitor 1A Homo sapiens 129-133 11373271-5 2001 After tetracycline withdrawal, cell death and multinucleated giant cells were observed with increased hRAD50 expression, and p21(WAF1/CIP1) but not p53 was increased. Tetracycline 6-18 cyclin dependent kinase inhibitor 1A Homo sapiens 134-138 9661919-5 1998 We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage. Tetracycline 160-172 cyclin dependent kinase inhibitor 1A Homo sapiens 140-143 10974076-5 2000 METHODS: We overexpressed p21 with a tetracycline-inducible system in ER-negative, p21-negative breast cancer cells. Tetracycline 37-49 cyclin dependent kinase inhibitor 1A Homo sapiens 26-29 10974076-5 2000 METHODS: We overexpressed p21 with a tetracycline-inducible system in ER-negative, p21-negative breast cancer cells. Tetracycline 37-49 cyclin dependent kinase inhibitor 1A Homo sapiens 83-86 9824154-4 1998 Here, we show, using a tetracycline-regulated system in p53-deficient DLD-1 human colon cancer cells, that p21 protein levels and stability are regulated by the proteasome-dependent degradation pathway and by association with its partners, CDKs and PCNA. Tetracycline 23-35 cyclin dependent kinase inhibitor 1A Homo sapiens 107-110 10347252-3 1999 Upon p21(waf1) induction by tetracycline withdrawal, we observed a reduced apoptotic response to paclitaxel with a 3- to 6-fold increase in IC50 values compared with that of cells not induced by p21(waf1). Tetracycline 28-40 cyclin dependent kinase inhibitor 1A Homo sapiens 5-8 9661919-5 1998 We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage. Tetracycline 160-172 cyclin dependent kinase inhibitor 1A Homo sapiens 144-148 9661919-5 1998 We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage. Tetracycline 160-172 cyclin dependent kinase inhibitor 1A Homo sapiens 149-153 9661919-5 1998 We found that these cells are positive for Ki-67 even when they are arrested in G1/S or G2/M by using synchronizing inhibitors, by inducing p21(Waf1/Cip1) in a tetracycline-regulated expression system or by inducing wild type p53 and p21 after inflicting DNA damage. Tetracycline 160-172 cyclin dependent kinase inhibitor 1A Homo sapiens 234-237 9366521-5 1997 Induction of p16, p21 or p27, using the tetracycline repressor system, potently inhibits proliferation of U343 cells. Tetracycline 40-52 cyclin dependent kinase inhibitor 1A Homo sapiens 18-21 9575175-6 1998 Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein. Tetracycline 87-99 cyclin dependent kinase inhibitor 1A Homo sapiens 240-243 9575175-6 1998 Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein. Tetracycline 87-99 cyclin dependent kinase inhibitor 1A Homo sapiens 244-248 9575175-6 1998 Employing a stable cell line derived from p53-deficient human fibroblast that contains tetracycline-regulated transactivator and operator plasmids to control the expression of wild-type p53 (TR9-7 cells), we then show that the induction of p21(WAF1/Cip1), which occurs in response to the inhibition of PP5 expression, requires the p53 protein. Tetracycline 87-99 cyclin dependent kinase inhibitor 1A Homo sapiens 249-253 9467956-3 1998 Here, we show, using a tetracycline-regulated system, that expression of wild-type p21 in p53-deficient DLD1 human colon cancer cells inhibits DNA synthesis and causes G1 and G2 cell cycle arrest. Tetracycline 23-35 cyclin dependent kinase inhibitor 1A Homo sapiens 83-86 9467962-4 1998 The maximum induced p21 levels in the absence of Tet were estimated to be ten times that of endogenous hamster p21. Tetracycline 49-52 cyclin dependent kinase inhibitor 1A Homo sapiens 20-23 9467962-5 1998 As p21 levels rose following removal of Tet, p21-associated histone H1 kinase activity was increased and concomitantly cell growth and DNA synthesis were reduced. Tetracycline 40-43 cyclin dependent kinase inhibitor 1A Homo sapiens 3-6 9467962-5 1998 As p21 levels rose following removal of Tet, p21-associated histone H1 kinase activity was increased and concomitantly cell growth and DNA synthesis were reduced. Tetracycline 40-43 cyclin dependent kinase inhibitor 1A Homo sapiens 45-48 9467962-6 1998 Tet-p21 BHK21 cells became arrested in G1 phase and lost colony forming ability irreversibly 2-4 days after removal of Tet. Tetracycline 0-3 cyclin dependent kinase inhibitor 1A Homo sapiens 4-7 9467962-6 1998 Tet-p21 BHK21 cells became arrested in G1 phase and lost colony forming ability irreversibly 2-4 days after removal of Tet. Tetracycline 119-122 cyclin dependent kinase inhibitor 1A Homo sapiens 4-7 9467962-7 1998 The induction of cyclin E- and cyclin A-associated kinase activities was diminished when G0-synchronized Tet-p21 BHK21 cells were serum stimulated in the absence of Tet. Tetracycline 105-108 cyclin dependent kinase inhibitor 1A Homo sapiens 109-112