PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26536660-2 2015 In this study, and by means of the stable transfection of MCF-7 cells with ACSL4 using the tetracycline Tet-Off system (MCF-7 Tet-Off/ACSL4), we identify the mTOR pathway as one of the main specific signatures of ACSL4 expression and demonstrate the partial involvement of the lipoxygenase pathway in the activation of mTOR. Tetracycline 91-103 mechanistic target of rapamycin kinase Homo sapiens 158-162 23243017-2 2013 Tetracycline-inducible Bcl-2 and Bcl-xL dual knockdown sharply increased PI3K/AKT/mTOR inhibitor lethality. Tetracycline 0-12 mechanistic target of rapamycin kinase Homo sapiens 82-86 24280420-6 2014 Furthermore, we observed that long term tetracycline incubation also caused inhibition of the mTOR complex, a central regulator of cell metabolism, further contributing to the observed cell-cycle arrest and autophagy in doxycycline- and minocycline-treated cell lines. Tetracycline 40-52 mechanistic target of rapamycin kinase Homo sapiens 94-98 29590189-9 2018 Our collection allows tetracycline-inducible expression of proteins with various tags suitable for protein localization, FRET, bimolecular fluorescence complementation (BiFC), protein dynamics studies (FRAP), co-immunoprecipitation, the RNA tethering assay and cell sorting. Tetracycline 22-34 mechanistic target of rapamycin kinase Homo sapiens 202-206