PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30401630-2 2019 Our results outlined that abrogation of PI3K using pan-PI3K inhibitor BKM120 decreased survival of MM cells through induction of a caspase-3-dependent apoptosis coupled with SIRT1-mediated G2/M arrest in both KMM-1 and RPMI 8226 cell lines; however, the cell responses to the inhibitor was quite different, introducing wild-type PTEN-expressing RPMI 8226 as less sensitive cells. NVP-BKM120 70-76 sirtuin 1 Homo sapiens 174-179