PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24451154-14 2014 In a PIK3CA-mutant HER2+ xenograft, PI3K inhibition with BKM120 in combination with lapatinib and trastuzumab was required to achieve tumor regression. NVP-BKM120 57-63 erb-b2 receptor tyrosine kinase 2 Mus musculus 19-23 28396358-2 2017 We previously showed that HER2+/PIK3CAH1047R transgenic mammary tumors are resistant to the HER2 antibodies trastuzumab and pertuzumab but respond to PI3K inhibitor buparlisib (TPB). NVP-BKM120 165-175 erb-b2 receptor tyrosine kinase 2 Mus musculus 26-30 30705430-2 2019 The sentence should read "In mouse mammary tumour models, increased collagen levels and increased beta1 integrin and SRC activity have been demonstrated to accompany, and promote, combined resistance to anti-human epidermal growth factor receptor 2 (HER2; also known as ERBB2) (trastuzumab and pertuzumab) and anti-PI3K (buparlisib) therapies164." NVP-BKM120 321-331 erb-b2 receptor tyrosine kinase 2 Mus musculus 250-254