PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29515122-0	2018	Pan-class I  PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53.	NVP-BKM120	34-40	tumor protein p53	Homo sapiens	171-174	
29515122-8	2018	Upon re-expression of wt p53 in these p53 mutated cells, BKM120-induced polyploidy is strongly reduced demonstrating that the genetic status of the cells determines the outcome of a BKM120-mediated pathway inhibition.	NVP-BKM120	57-63	tumor protein p53	Homo sapiens	25-28	
29515122-8	2018	Upon re-expression of wt p53 in these p53 mutated cells, BKM120-induced polyploidy is strongly reduced demonstrating that the genetic status of the cells determines the outcome of a BKM120-mediated pathway inhibition.	NVP-BKM120	57-63	tumor protein p53	Homo sapiens	38-41	
29515122-8	2018	Upon re-expression of wt p53 in these p53 mutated cells, BKM120-induced polyploidy is strongly reduced demonstrating that the genetic status of the cells determines the outcome of a BKM120-mediated pathway inhibition.	NVP-BKM120	182-188	tumor protein p53	Homo sapiens	25-28	
29515122-8	2018	Upon re-expression of wt p53 in these p53 mutated cells, BKM120-induced polyploidy is strongly reduced demonstrating that the genetic status of the cells determines the outcome of a BKM120-mediated pathway inhibition.	NVP-BKM120	182-188	tumor protein p53	Homo sapiens	38-41	
27599915-7	2016	In conclusion, we suggest NVP-BKM120 induces apoptosis through p53-dependent and -independent mechanisms, indicating the potential application of the inhibitor in both wild-type and deficient p53-expressing leukemic cells.	NVP-BKM120	30-36	tumor protein p53	Homo sapiens	63-66	
27599915-7	2016	In conclusion, we suggest NVP-BKM120 induces apoptosis through p53-dependent and -independent mechanisms, indicating the potential application of the inhibitor in both wild-type and deficient p53-expressing leukemic cells.	NVP-BKM120	30-36	tumor protein p53	Homo sapiens	192-195	
22065080-0	2012	Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells.	NVP-BKM120	26-32	tumor protein p53	Homo sapiens	128-131	
22065080-13	2012	CONCLUSION: Our present findings establish that NVP-BKM120 inhibits the PI3K signaling pathways, leading to different forms of cell death on the basis of p53 statuses.	NVP-BKM120	52-58	tumor protein p53	Homo sapiens	154-157