PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26044191-2 2015 Based on our observation that TRAIL-resistant glioma cell lines typically exhibited high levels of Akt activation, we hypothesized that inhibition of Akt signaling using the PI3 kinase inhibitor NVP-BKM120 could promote TRAIL-induced apoptosis in gliomas. NVP-BKM120 199-205 TNF superfamily member 10 Homo sapiens 30-35 26044191-2 2015 Based on our observation that TRAIL-resistant glioma cell lines typically exhibited high levels of Akt activation, we hypothesized that inhibition of Akt signaling using the PI3 kinase inhibitor NVP-BKM120 could promote TRAIL-induced apoptosis in gliomas. NVP-BKM120 199-205 TNF superfamily member 10 Homo sapiens 220-225 23562472-0 2013 The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis. NVP-BKM120 29-35 TNF superfamily member 10 Homo sapiens 142-147 23562472-1 2013 This study focuses on determining whether and how the novel PI3 kinase inhibitor NVP-BKM120 (BKM120) induces apoptosis and enhances TRAIL-induced apoptosis in human lung cancer cells. NVP-BKM120 85-91 TNF superfamily member 10 Homo sapiens 132-137 23562472-1 2013 This study focuses on determining whether and how the novel PI3 kinase inhibitor NVP-BKM120 (BKM120) induces apoptosis and enhances TRAIL-induced apoptosis in human lung cancer cells. NVP-BKM120 93-99 TNF superfamily member 10 Homo sapiens 132-137 23562472-2 2013 We found that BKM120 reduced Mcl-1 levels across the tested cell lines along with induction of apoptosis and enhancement of TRAIL-induced apoptosis. NVP-BKM120 14-20 TNF superfamily member 10 Homo sapiens 124-129