PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33637776-11	2021	Meanwhile, BKM120 inhibited the expression of BRAC1/2 and Rad51/52 to block HR mediated repair through the PI3K/Akt/NFkappaB/c-Myc signaling pathway and PI3K/Akt/ FOXM1/Exo1 signaling pathway.	NVP-BKM120	11-17	nuclear factor kappa B subunit 1	Homo sapiens	116-124	
32160736-4	2020	Investigating the effect of inhibitor on the molecular feature revealed that not only BKM120 reduced the expression of NF-kappaB anti-apoptotic targets, but also NF-kappaB suppression using bortezomib profoundly enhanced the cytotoxicity of the inhibitor; highlighting that the anti-leukemic effects of BKM120 is mediated, at least partly, through the modulation of NF-kappaB pathway.	NVP-BKM120	86-92	nuclear factor kappa B subunit 1	Homo sapiens	119-128	
30401630-4	2019	As far as we are aware, the results of the present study propose for the first time that the inhibitory effect of BKM120 was overshadowed, at least partially, through over-expression of either c-Myc or nuclear factor (NF)-kappaB in less sensitive MM cells.	NVP-BKM120	114-120	nuclear factor kappa B subunit 1	Homo sapiens	202-228	
29151909-0	2017	BKM120 sensitizes C6 glioma cells to temozolomide via suppression of the PI3K/Akt/NF-kappaB/MGMT signaling pathway.	NVP-BKM120	0-6	nuclear factor kappa B subunit 1	Homo sapiens	82-91	
29151909-13	2017	However, a low concentration of BKM120 inhibited the PI3K/Akt/NF-kappaB signaling pathway activity in glioma cells and significantly increased TMZ cytotoxicity.	NVP-BKM120	32-38	nuclear factor kappa B subunit 1	Homo sapiens	62-71	
29151909-17	2017	The reduction of NF-kappaB p65 in combination treatment supported the hypothesis that BKM120 may mediate MGMT transcription via inhibition of NF-kappaB p65.	NVP-BKM120	86-92	nuclear factor kappa B subunit 1	Homo sapiens	17-26	
29151909-17	2017	The reduction of NF-kappaB p65 in combination treatment supported the hypothesis that BKM120 may mediate MGMT transcription via inhibition of NF-kappaB p65.	NVP-BKM120	86-92	nuclear factor kappa B subunit 1	Homo sapiens	142-151	
29151909-19	2017	The BKM120-induced NF-kappaB p65 inhibition may be involved in the mediation of MGMT transcription to reverse TMZ-resistance in C6 glioma cells.	NVP-BKM120	4-10	nuclear factor kappa B subunit 1	Homo sapiens	19-28	
26673665-7	2015	BKM120 activity induced the blockage of PI3K/AKT signaling and NF-kappaB expression, which in turn led to activate caspase-3/7 and caspase-9 and changed the expression of several apoptosis-related gene expression.	NVP-BKM120	0-6	nuclear factor kappa B subunit 1	Homo sapiens	63-72	
26673665-9	2015	Our findings indicate that BKM120 partially overcomes the MDR phenotype in chemoresistant breast cancer through cell apoptosis induction and CSC abolishing, which appears to be mediated by the inhibition of the PI3K/AKT/NF-kappaB axis.	NVP-BKM120	27-33	nuclear factor kappa B subunit 1	Homo sapiens	220-229